METHODS: We describe the case of a 61-year-old female who developed a CML after 8 years of treatment with azathioprine (AZA) for ileal Crohn\'s disease associated with a duodenal localization. We reviewed the current evidence on the interactions between CD, CML and AZA as well as the potential underlying mechanisms of leukemia in AZA-treated patients.
CONCLUSIONS: We concluded that the pathogenesis of CML is multifactorial in CD. The nature of the association between AZA and CML in CD patients warrants further investigation.
我们描述了一个61岁的女性病例,她在用硫唑嘌呤(AZA)治疗与十二指肠定位相关的回肠克罗恩病8年后发展为CML。我们回顾了目前关于CD之间相互作用的证据,慢性粒细胞白血病和AZA以及AZA治疗患者白血病的潜在潜在潜在机制。
我们得出结论,CML的发病机制在CD中是多因素的。CD患者中AZA与CML之间的关联性质值得进一步研究。