Abstract：
BACKGROUND: Patients with Cohn\'s disease (CD) treated with thiopurines are at an increased risk of developing cancer. Leukemias are less frequent than other hematopoietic tumors and the development of Chronic myeloid leukemia (CML) after immunosuppression has not been proven.
METHODS: We describe the case of a 61-year-old female who developed a CML after 8 years of treatment with azathioprine (AZA) for ileal Crohn\'s disease associated with a duodenal localization. We reviewed the current evidence on the interactions between CD, CML and AZA as well as the potential underlying mechanisms of leukemia in AZA-treated patients.
CONCLUSIONS: We concluded that the pathogenesis of CML is multifactorial in CD. The nature of the association between AZA and CML in CD patients warrants further investigation.
METHODS: We describe the case of a 61-year-old female who developed a CML after 8 years of treatment with azathioprine (AZA) for ileal Crohn\'s disease associated with a duodenal localization. We reviewed the current evidence on the interactions between CD, CML and AZA as well as the potential underlying mechanisms of leukemia in AZA-treated patients.
CONCLUSIONS: We concluded that the pathogenesis of CML is multifactorial in CD. The nature of the association between AZA and CML in CD patients warrants further investigation.
摘要：
接受硫嘌呤治疗的Cohn病（CD）患者患癌症的风险增加。白血病的发生频率低于其他造血系统肿瘤，免疫抑制后慢性粒细胞白血病（CML）的发展尚未得到证实。
我们描述了一个61岁的女性病例，她在用硫唑嘌呤（AZA）治疗与十二指肠定位相关的回肠克罗恩病8年后发展为CML。我们回顾了目前关于CD之间相互作用的证据，慢性粒细胞白血病和AZA以及AZA治疗患者白血病的潜在潜在潜在机制。
我们得出结论，CML的发病机制在CD中是多因素的。CD患者中AZA与CML之间的关联性质值得进一步研究。
我们描述了一个61岁的女性病例，她在用硫唑嘌呤（AZA）治疗与十二指肠定位相关的回肠克罗恩病8年后发展为CML。我们回顾了目前关于CD之间相互作用的证据，慢性粒细胞白血病和AZA以及AZA治疗患者白血病的潜在潜在潜在机制。
我们得出结论，CML的发病机制在CD中是多因素的。CD患者中AZA与CML之间的关联性质值得进一步研究。
