目的:肠易激综合征(IBS)是一种常见的胃肠道疾病,免疫,心理,和饮食因素。最近,环境暴露之间的潜在相关性,比如空气污染,IBS引起了人们的注意。这篇综述旨在系统地研究与IBS相关的环境因素的现有研究。阐明这种相互作用,并指导未来的研究。
方法:在Medline进行了文献检索,EMBASE,Scopus,和Cochrane数据库从数据库开始到2023年10月10日,使用关键字\“易激肠道\”或IBS或\“易激结肠\”或\“粘液结肠炎\”或\“痉挛性结肠炎\”或\“痉挛性结肠\”和\“环境*暴露\*”。如果研究是原创的,以英文出版,描述的定义的环境暴露,并有记录诊断为IBS。就本次审查而言,报道物理(如辐射和气候变化)的文章,生物(例如细菌和病毒),和化学(如有害气体)暴露被包括在内,而心理和饮食因素,已在其他地方进行了详细的审查,超出了范围。
结果:总共有7项研究关注空气质量,微生物暴露,和其他环境因素进行了综述。研究强调了空气污染物与IBS发病率增加之间的潜在关联。微生物暴露,自然灾害后或由于卫生条件差,与IBS发育和肠道菌群失调有关。其他暴露,比如早期拥有宠物,也与IBS风险相关。
结论:现有研究表明环境暴露与IBS发展之间存在流行病学关系。需要进一步的研究来理解这些关联。
OBJECTIVE: Irritable bowel syndrome (
IBS) is a common gastrointestinal disorder with roots in genetic, immune, psychological, and dietary factors. Recently, the potential correlation between environmental exposures, such as air pollution, and IBS has gained attention. This
review aimed to systematically examine existing studies on environmental factors associated with
IBS, elucidating this interplay and guiding future research.
METHODS: A literature search was conducted in Medline, EMBASE, Scopus, and Cochrane databases from database inception to October 10, 2023, using the keywords \"Irritable Bowel\" or IBS or \"Irritable Colon\" or \"Mucous Colitis\" or \"Spastic Colitis\" or \"Spastic Colon\" AND \"environment* exposure*\". Studies were included if they were original, published in English, described defined environmental exposure(s), and had documented diagnosis of IBS. For the purposes of this
review, articles reporting physical (e.g. radiation and climate change), biological (e.g. bacteria and viruses), and chemical (e.g. harmful gases) exposures were included while psychological and dietary factors, which have been reviewed in detail elsewhere, are outside of the scope.
RESULTS: A total of seven studies focusing on air quality, microbial exposure, and other environmental factors were reviewed. Studies highlighted a potential association between air pollutants and increased IBS incidence. Microbial exposure, post-natural disaster or due to poor sanitation, was linked to IBS development and gut dysbiosis. Other exposures, such as early pet ownership, were also associated with
IBS risk.
CONCLUSIONS: Existing research demonstrates an epidemiologic relationship between environmental exposures and the development of IBS. Further research is needed to understand these associations.