PDF(Pubmed)
Abstract：
The intestine is essential for the modulation of nutrient absorption and the removal of waste. Gut pathologies, such as cancer, inflammatory bowel diseases (IBD), irritable bowel syndrome (IBS), and celiac disease, which extensively impact gut functions, are thus critical for human health. Targeted drug delivery is essential to tackle these diseases, improve therapy efficacy, and minimize side effects. Recent strategies have taken advantage of both active and passive nanocarriers, which are designed to protect the drug until it reaches the correct delivery site and to modulate drug release via the use of different physical-chemical strategies. In this systematic review, we present a literature overview of the different nanocarriers used for drug delivery in a set of chronic intestinal pathologies, highlighting the rationale behind the controlled release of intestinal therapies. The overall aim is to provide the reader with useful information on the current approaches for gut targeting in novel therapeutic strategies.
摘要：
肠道对于调节营养吸收和去除废物至关重要。肠道病变,比如癌症，炎症性肠病（IBD），肠易激综合征（IBS），和乳糜泻,广泛影响肠道功能，因此对人类健康至关重要。靶向药物递送对于解决这些疾病至关重要，提高治疗效果，尽量减少副作用。最近的策略利用了主动和被动纳米载体，它们旨在保护药物，直到它到达正确的递送部位，并通过使用不同的物理化学策略来调节药物释放。在这次系统审查中，我们提供了在一组慢性肠道病变中用于药物递送的不同纳米载体的文献概述，强调控制释放肠道疗法背后的基本原理。总体目标是为读者提供有关新型治疗策略中的当前肠道靶向方法的有用信息。
