背景:Pythium,土壤传播的植物病原体,在卵菌类里。它们不是真正的真菌,但与硅藻和藻类有关。有两种人类病原体,包括阴间假单胞菌和耳膜假单胞菌。迄今为止,目前仅有一例由隐耳虫引起的化脓症。我们在此介绍了亚洲首例隐线虫病血管化脓症。
方法:一位47岁的泰国妇女,生活在泰国北部,β地中海贫血/血红蛋白E表现为双腿急性复发性动脉供血不足。进行紧急取栓和凝块清除。凝块的病理学表现为非干酪样肉芽肿性炎症,并伴有许多真菌菌丝成分。PCR鉴定了具有100%同一性的隐蔽物。最终诊断为血管化脓。不幸的是,患者最终在接受伊曲康唑治疗后死亡,特比萘芬,阿奇霉素,和强力霉素.
结论:迄今为止,目前仅有一例由隐耳虫引起的化脓症。我们在此介绍了亚洲首例隐线虫病血管化脓症。
BACKGROUND: Pythium, soil-borne plant pathogens, are in the class Oomycetes. They are not true fungi, but are related to diatom and algae. There are two human pathogens including P. insidiosum and P. aphanidermatum. To date, only one
case of pythiosis caused by P. aphanidermatum has been reported. We present herein the first
case of P. aphanidermatum vascular pythiosis in Asia.
METHODS: A 47-year-old Thai woman, living in North Thailand, with ß thalassemia/hemoglobin E presented with acute recurrent arterial insufficiency of both legs. Emergent embolectomy with clot removal was performed. The pathology of the clot exhibited noncaseous granulomatous inflammation with many fungal hyphal elements. PCR identified P. aphanidermatum with 100% identity. Final diagnosis is vascular pythiosis. Unfortunately, the patient eventually expired after treatment with itraconazole, terbinafine, azithromycin, and doxycycline.
CONCLUSIONS: To date, only one
case of pythiosis caused by P. aphanidermatum has been reported. We present herein the first
case of P. aphanidermatum vascular pythiosis in Asia.