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Abstract：
Cladophialophora bantiana brain abscesses are rare, but are frequently and quickly lethal in transplanted patients. We report the case of a 63-year-old man who had undergone lung transplantation for chronic obstructive pulmonary disease and presented with headaches and a neurological deficit. Magnetic resonance imaging revealed multiple brain abscesses. C. bantiana was identified by DNA sequencing performed directly on cerebral tissue obtained by surgical biopsy. After 6 months of antifungal treatment, the brain abscesses were replaced by ischemic sequelae. The patient died suddenly 2 months later from a pulmonary bacterial infection. This is the second reported case of C. bantiana brain abscesses in a lung transplant recipient, to our knowledge, who experienced a long survival period with medical antifungal treatment alone. We review the literature and discuss our treatment.
摘要：
紫罗兰脑脓肿很少见，但在移植患者中经常和迅速致命。我们报告了一名63岁的男子，该男子因慢性阻塞性肺疾病接受了肺移植，并出现头痛和神经功能缺损。磁共振成像显示多发性脑脓肿。通过直接对手术活检获得的脑组织进行DNA测序来鉴定C.bantiana。经过6个月的抗真菌治疗，脑脓肿被缺血性后遗症所取代。患者在2个月后突然死于肺部细菌感染。这是在肺移植受者中报道的第二例C.bantiana脑脓肿，根据我们的知识，仅通过医学抗真菌治疗就经历了很长的生存期。我们回顾了文献并讨论了我们的治疗方法。
