抑郁症和精神分裂症是2种严重的精神障碍。他们的有效治疗是当前紧迫的医学和社会问题。药物治疗是改善精神障碍的基本措施,尤其是严重的精神障碍。然而,传统抗精神病药物的副作用是无法避免的。令人惊讶的是,近年来,已经发现一氧化氮(NO),一氧化碳(CO),在动物模型中,硫化氢(H2S)和氢气(H2)可以调节相应的信号通路来治疗精神疾病。更重要的是,作为气体信号分子,它们在代谢后不会带来毒性和副作用。因此,在这次审查中,在一些动物模型中,我们通过内源性气体产生和外源性气体输送策略分析了气体对抑郁和精神分裂症的影响。内源性气体产生策略:综述了气体信号分子对抑郁症和精神分裂症的治疗机制,并列举了抑制或刺激气体产生的主要途径。外部气体输送策略:总结了常见的外部刺激响应性气体传递剂前药以及这些前药在治疗抑郁症和精神分裂症中的一些研究。我们还分析了纳米气体载体治疗抑郁症和精神分裂症的前景。通过这次审查,我们希望通过调节相关气体信号通路,为抑郁症和精神分裂症的治疗提供指导,通过对外源性气体药物的总结,为开发治疗精神障碍安全有效的药物提供参考。
Depression and schizophrenia are 2 serious mental disorders. Their effective treatment is an urgent medical and social problem at present. Drug treatment is the basic measure to improve mental disorders, especially serious mental disorders. However, the side effects of traditional antipsychotic drugs cannot be avoided. Surprisingly, in recent years, it has been found that nitric oxide (NO), carbon monoxide (CO), hydrogen sulfide (H2S) and hydrogen (H2) can regulate corresponding signal pathways to treat mental diseases in animal models. More importantly, as gas signal molecules, they will not bring toxicity and side effects after metabolism. Therefore, in this
review, we analyzed the effects of gas on depression and schizophrenia through endogenous gas generation and external gas delivery strategies in some animal models. Endogenous gas generation strategy: summarized the therapeutic mechanism of gas signaling molecules on depression and schizophrenia, and listed the main ways to inhibit or stimulate gas generation. External gas delivery strategy: The common external stimuli-responsive gasotransmitter prodrugs and some study of these prodrugs in the treatment of depression and schizophrenia are summarized. We also analyzed the prospects of nano-gas carrier in the treatment of depression and schizophrenia. Through this
review, we hope to provide guidance for treating depression and schizophrenia by regulating relevant gas signal pathways, and provide reference for developing safe and effective drugs for treating mental disorders by summarizing exogenous gas drugs.