human papilloma virus

人乳头瘤病毒
  • 文章类型: Journal Article
    在摩洛哥,宫颈癌筛查率仍然很低,这决定了需要采用新的筛查方法。用于HPV检测的阴道自采样是这些策略之一。预计CC筛查计划的变化,我们希望向卫生当局提出关于摩洛哥女性人群中HPV检测的阴道自我取样的可接受性和偏好性的全球观点.这项初步研究的目的是评估摩洛哥女性人群中阴道自我取样对HPV检测的可接受性和偏好。一项横断面研究调查了400名年龄在25至65岁之间的摩洛哥女性,他们是从摩洛哥三个地区的不同医疗机构招募的,2022年3月至11月。数据是通过访谈收集的,使用问卷。在400名参与者中,380(95%)准备接受阴道自我取样进行HPV检测。在表示愿意进行这项测试的参与者中,295(73.6%)更喜欢在家中进行。HPV自我取样的可能性降低是通过相信只有有阴道分泌物或出血的女性需要进行筛查来确定的。年龄,婚姻状况,CC的感知严重性,练习CC筛选,和感知自我效能感被确定为影响HPV检测家庭阴道自我取样偏好的主要因素。用于HPV检测的阴道自采样是一种替代选择,可以克服摩洛哥背景下定义的一系列筛查障碍。以增加CC筛查覆盖率。
    In Morocco, cervical cancer screening rate is still low, which determines the need to adopt new screening approaches. Vaginal self-sampling for HPV testing is one of these strategies. Anticipating changes in screening plans for CC, we would like to present to health authorities a global view about the acceptability and preference of vaginal self-sampling for HPV testing among a population of Moroccan women. The aim of this pilot study is to assess the acceptability and preference of vaginal self-sampling for HPV testing among a population of Moroccan women. A cross-sectional study surveyed 400 Moroccan women aged between 25 and 65 years, who are recruited from various healthcare facilities in three Moroccan regions, between March and November 2022. Data were collected via interviews, using a questionnaire. Among the 400 participants, 380 (95%) were ready to undergo a vaginal self-sampling for HPV testing. Among participants who expressed their willingness to perform this test, 295 (73.6%) prefer to carry out it at home. A decreased likelihood of HPV self-sampling was determined by belief that only women with vaginal discharge or bleeding need to be screened. Age, marital status, perceived severity of CC, practice CC screening, and perceived self-efficacy were identified as the main factors influencing the preference for home based vaginal self-sampling for HPV testing. Vaginal self-sampling for HPV testing is an alternative option that could overcome a set of screening barriers defined in the Moroccan context, in order to increase CC screening coverage.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    宫颈癌是孟加拉国一个重要的公共卫生问题。尽管政府努力,农村地区的意识和医疗保健利用不足。
    这项横断面研究是在Barishal部门的六个地区进行的,年龄在15-64岁之间的997名受访者。人口统计学变量,医疗保健的可及性,疫苗接种状况,对HPV引起宫颈癌的认识,通过结构化问卷记录HPV疫苗知识.使用单变量T检验和双变量分析的卡方检验。Logistic回归用于确定与意识相关的因素。
    大多数参与者通过了SSC(45.3%),失业者(54.4%),已婚(74.4%)。83.5%的人知道宫颈癌,只有3.3%的人知道HPV的作用。大多数(96.2%)从未检测过HPV。尽管79.5%的人知道疫苗,只有2.45%接种了疫苗。知识水平很低,只有1.4%的人表现出良好的知识,主要与更高的收入联系在一起,居住在靠近医疗机构的地方,和结婚。Bhola地区的参与者意识最高,最低的是在Pirojpur.受教育程度与知识水平呈正相关,毕业生最清楚。Logistic回归显示教育,婚姻状况,愿意给女儿接种疫苗,和地区与更好的意识显著相关,而收入,距离,年龄没有。
    大规模的教育和宣传活动可以提高农村社区的意识水平。
    UNASSIGNED: Cervical cancer is an important public health issue in Bangladesh. Despite government efforts, the awareness and healthcare utilization in rural areas are inadequate.
    UNASSIGNED: This cross-sectional study was conducted in six districts of Barishal division over 997 respondents aged 15-64 years. The demographic variables, accessibility to healthcare, vaccination status, awareness of HPV causing cervical cancer, and knowledge of the HPV vaccine were recorded through a structured questionnaire. T-test for univariate and chi-square test for bi-variate analysis were used. Logistic regression was used to determine factors associated with awareness.
    UNASSIGNED: Most of the participants were SSC passed (45.3%), unemployed (54.4%), and married (74.4%). While 83.5% were aware of cervical cancer, only 3.3% knew about HPV\'s role. The majority (96.2%) had never been tested for HPV, albeit 79.5% knew about the vaccine, and only 2.45% were vaccinated. Knowledge levels were low, with only 1.4% demonstrating sound knowledge, mostly associating with higher income, residing closer to healthcare facilities, and being married. Bhola district participants had highest level of awareness, and the lowest was in Pirojpur. Education level was positively correlated with knowledge, with graduates being most aware. Logistic regression showed education, marital status, willingness to vaccinate daughters, and district were significantly related with better awareness, while income, distance, and age did not.
    UNASSIGNED: Mass education and awareness campaigns may improve the awareness level in rural community.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    目的:这项研究的目的是描述丹麦喉乳头状瘤病(LP)的发病率和人口统计学,包括性别和年龄分布,复发率,和HPV亚型,使用一种新的寄存器识别方法。
    方法:使用SNOMED代码从丹麦病理学数据库中提取数据,而不是使用丹麦国家卫生注册中心的ICD代码的常规方法。衍生的病理记录由三名医生手动验证。研究期为1994-2021年。根据年龄将患者分类为青少年发病RRP(JoRRP)(如果<18岁)或成人发病RRP(AoRRP)(如果18岁或以上)。
    结果:我们确定了1819例RRP患者(JoRRP:56;AoRRP:1763)。JoRRP每100,000居民的总发病率为0.17,AoRRP为1.45。绝大多数(72%)的患者是男性,但RRP发病年龄或性别间复发率无显著差异.3岁以下儿童的复发概率最高。使用SNOMED代码提取数据导致关于活检总数的阳性预测值为99%,关于个体的阳性预测值为98%。在整个研究期间发病率下降。
    结论:丹麦和挪威的RRP发病率和复发率相当。在这项研究中,发现丹麦病理学注册是一种非常有价值的鉴定LP患者的方法.可以使用这种方法评估全国HPV疫苗接种计划的效果,因为接种疫苗的队列开始变老和繁殖。
    方法:基于回顾性注册的国家队列研究,证据水平3喉镜,2024.
    OBJECTIVE: The aim of this study is to describe the incidence and demographics of laryngeal papillomatosis (LP) in Denmark, including sex and age distribution, recurrence rates, and HPV subtypes, using a new method of register identification.
    METHODS: The data were extracted from the Danish Pathology Data Bank using SNOMED codes instead of the usual method using ICD codes from the Danish National Health Register. The derived pathology records were manually verified by three medical doctors. The study period was 1994-2021. Patients were categorized according to age as either juvenile-onset RRP (JoRRP) if <18 years or adult-onset RRP (AoRRP) if 18 years or older.
    RESULTS: We identified 1819 RRP patients (JoRRP: 56; AoRRP:1763). The overall incidence per 100,000 inhabitants were 0.17 for JoRRP and 1.45 for AoRRP. The vast majority (72%) of the patients were male, but there was no significant difference in age at onset of RRP or recurrence rates between the sexes. Children below 3 years of age had the highest recurrence probability. Extracting data using SNOMED codes resulted in a positive predictive value of 99% regarding total number of biopsies and 98% regarding individuals. The incidence decreased throughout the study period.
    CONCLUSIONS: Comparable incidence and recurrence rates of RRP were found between Denmark and Norway. In this study, the Danish Pathology Register was found to be a highly valuable method for identifying LP patients. The effect of the nationwide HPV vaccination program can be evaluated using this method as the vaccinated cohort is starting to grow older and reproduce.
    METHODS: Retrospective registry-based national cohort study, level of evidence 3 Laryngoscope, 2024.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    宫颈癌是发展中国家妇女妇科癌症死亡的主要原因,也是所有妇科癌症中最可预防的传染性病原体,人乳头瘤病毒(HPV),是已知的。分区域中HPV血清型分布的知识是实施适当的HPV疫苗接种计划的关键。
    为了评估HPV-DNA的患病率,Katsina州浸润性宫颈癌(ICC)女性的血清型和风险决定因素,尼日利亚西北部。
    这是一个横截面,涉及联邦教学医院Katsina的多中心研究,总医院Katsina和TuraiYar\'adua妇幼保健院Katsina,尼日利亚。63名经组织学证实符合该标准的宫颈癌妇女被招募到研究中。已确认ICC诊断的组织块被带到DNALabsKaduna进行HPV脱氧核糖核苷酸检测和分型。为这项研究开发的面试官管理的问卷被用来获得社会人口统计,生殖特征以及HPV获取和持续的其他危险因素。
    ICC中的HPV阳性率为95.5%,而标本中的高危型HPV(Hr-HPV)-DNA的患病率为54.6%,检测到13种HPV血清型,9个Hr-HPV类型(16,18,31,33,35,45,51,56,82)和4个低风险HPV类型(6,44,81,89)。在单一HPV感染的女性中最常见的HPV血清型是HPV81(40.9%),其次是HPV16(28.8%)。然而,HPV16是具有多种HPV感染的那些中最常见的血清型。其他检测到的血清型为HPV31(24.2%),33(24.2%),HPV18(10.6%),HPV35(3.0%),HPV45(9.1%),HPV44(1.5%),HPV51(3.0%),HPV56(3.0%),HPV82(1.5%),HPV89(1.5%)和HPV6(1.5%)。63名女性中有44名(69.8%)患有单一HPV感染,19例(30.2%)有多重HPV感染,15例(24.3%)与HPV16/31/33共感染。HPV16与鳞状细胞癌(SCC)之间存在统计学上的显着关联。
    该研究表明,ICC女性中HPV-DNA的患病率为95.5%。最常见的HPV血清型是41%的HPV81,这是一个罕见的发现。此外,在HPV血清型16和82与SCC之间检测到有统计学意义的关联.
    UNASSIGNED: Cervical cancer is the leading cause of gynaecological cancer death among women in developing countries and the most preventable of all gynaecological cancers as its infectious aetiological agent, human papillomavirus (HPV), is known. The knowledge of HPV serotype distribution in a sub-region is key to the implementation of an appropriate HPV vaccination programme.
    UNASSIGNED: To assess the prevalence of HPV-DNA, serotypes and risk-determinants among women with invasive cervical cancer (ICC) in Katsina State, Northwestern Nigeria.
    UNASSIGNED: This was a cross-sectional, multicenter study involving Federal Teaching Hospital Katsina, General Hospital Katsina and Turai Yar\'adua Maternal and Child Hospital Katsina, Nigeria. Sixty-three women with histologically confirmed cervical cancer who fulfilled the criteria were recruited into the study. Tissue blocks with a confirmed diagnosis of ICC were taken to DNA Labs Kaduna for HPV-deoxyribonucleotide acid detection and typing. An interviewer-administered questionnaire developed for the study was used to obtain socio-demographic, reproductive characteristics and the other risk factors for HPV acquisition and persistence.
    UNASSIGNED: The HPV-positivity rate in ICC was 95.5% while the prevalence of high-risk HPV (Hr-HPV)-DNA in the specimen was 54.6% with 13 HPV-serotypes detected, 9 Hr-HPV types (16,18,31,33,35,45,51,56,82) and 4 low-risk HPV types (6,44,81,89). The most commonly detected HPV serotype among women with a single HPV infection was HPV 81 (40.9%) followed by HPV 16 (28.8%). However, HPV 16 was the most common serotype among those with multiple HPV infections. Prevalence of other detected serotypes were HPV 31 (24.2%), 33 (24.2%), HPV 18 (10.6%), HPV 35 (3.0%), HPV 45 (9.1%), HPV 44 (1.5%), HPV 51 (3.0%), HPV 56 (3.0%), HPV 82 (1.5%), HPV 89 (1.5%) and HPV 6 (1.5%). Forty-four out of 63 women (69.8%) had a single HPV infection, 19 (30.2%) had multiple HPV infections and 15 (24.3%) were co-infected with HPV 16/31/33. There was a statistically significant association between HPV 16 and squamous cell carcinoma (SCC).
    UNASSIGNED: The study demonstrates a prevalence of HPV-DNA as 95.5% among women with ICC. The most commonly detected HPV serotype was HPV 81 seen in 41% which was an uncommon finding. Furthermore, statistically significant associations between HPV serotypes 16 and 82 with SCC were detected.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    背景:HPV被认为是最常见的性传播感染。它负责全世界70%的宫颈癌。HIV感染与HPV感染率增加有关。感染艾滋病毒(WLWH)的女性患宫颈癌的风险是其6倍。本研究旨在评估埃及WLWH与HIV阴性妇女相比的流行率和确定HPV感染的基因型,并确定相关的危险因素。
    方法:这项研究在埃及9个省初级保健中心妇科诊所招募的251名WLWH和268名HIV阴性状态妇女中进行。使用结构化访谈问卷从参与者收集数据,并收集宫颈样本用于HPVDNA检测和基因分型。
    结果:HPV感染的总体患病率为13.5%,感染艾滋病毒阴性的妇女中占3.4%,WLWH中占24.4%。从71%的受感染妇女中分离出基因型16和18以外的HR-HPV。女人的年龄,初婚年龄,终生婚姻数量和药物成瘾是HPV感染的重要预测因素(分别为赔率0.96,0.91,2.06,2.01).
    结论:HPV感染在WLWH中更为普遍。除基因型16和18以外的HR-HPV感染在两组中的感染妇女中最为普遍。年轻的年龄,早期性生活活动,一生中有不止一个性伴侣,药物成瘾是HPV感染的独立预测因子。有一个有其他性伴侣的丈夫与感染密切相关。
    BACKGROUND: HPV is considered the most common sexually transmitted infection. It is responsible of 70% of cervical cancers worldwide. HIV infection is associated with increased rates of HPV infection. Women Living With HIV (WLWH) are 6 times at greater risk of developing cervical cancer. The current study aimed to estimate prevalence and identify genotypes of HPV infection among WLWH in Egypt compared to women with negative HIV status and determine associated risk factors.
    METHODS: The study conducted among 251 WLWH and 268 women with negative HIV status enrolled from gynecological clinics in primary health care centers from nine Egyptian governorates. Data was collected from participants using a structured interview questionnaire and cervical samples were collected for HPV DNA detection and genotyping.
    RESULTS: The overall prevalence of HPV infection was 13.5%, 3.4% among women with HIV negative status and 24.4% among WLWH. HR-HPVs other than genotype 16 and 18 were isolated from 71% of infected women. Woman\'s age, age at first marriage, number of lifetime marriages and drug addiction are significant predictors for HPV infection (odds 0.96, 0.91, 2.06, 2.01 respectively).
    CONCLUSIONS: HPV infection is more prevalent among WLWH. Infection with HR-HPV other than genotype 16 and 18 was the most prevalent among infected women in both groups. Young age, early life sexual activity, having more than one sexual partner during the life time, and drug addiction are independent predictors for HPV infection. Having a husband who has had other sexual partners is significantly associated with infection.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    背景:肛门尖锐湿疣(CA)的特点是治疗方法棘手,复发率高。尽管5-氨基酮戊酸光动力疗法(ALA-PDT)在治疗肛门CA方面具有显着的疗效和安全性,它不能完全防止复发。这项研究旨在开发和验证列线图模型,以预测ALA-PDT治疗后肛门CA的HIV阴性患者的复发风险。
    方法:对2013年1月至2023年5月接受CO2激光汽化联合ALA-PDT治疗的肛门CA患者进行回顾性分析。将患者分为复发组和非复发组。根据在多变量逻辑回归分析中显示出统计学意义的因素制定了列线图。通过ROC曲线和决策曲线分析评估列线图的辨别能力和临床实用性,通过引导重采样执行内部验证。
    结果:在纳入的176例患者中,33例(18.75%)复发,143没有。复发的独立预测因素包括HPV类型,肛交史,以及接受CO2激光治疗的次数。结合这些预测因素,列线图显示了优异的诊断性能(曲线下面积=0.881,95%CI:0.818~0.935),并且在决策曲线分析中具有显著的净获益.
    结论:列线图准确预测了ALA-PDT后HIV阴性肛门CA患者的复发风险。它为指导术前临床决策和建立个性化治疗策略以最大程度地降低复发风险提供了有价值的工具。
    BACKGROUND: Anal condyloma acuminatum (CA) is marked by its thorny treatment and high recurrence rate. Although 5-aminolevulinic acid photodynamic therapy (ALA-PDT) demonstrates significant efficacy and safety in treating anal CA, it does not completely prevent recurrence. This study aimed to develop and validate a nomogram model in predicting the risk of relapse in HIV-negative patients with anal CA following treatment with ALA-PDT.
    METHODS: A retrospective analysis was conducted on patients diagnosed with anal CA who received combined CO2 laser vaporization and ALA-PDT between January 2013 and May 2023. Patients were divided into recurrence and non-recurrence groups. A nomogram was developed based on factors showing statistical significance in multivariable logistic regression analysis. The discriminative ability and clinical utility of the nomogram were assessed via ROC curves and decision curve analysis, with internal validation performed through bootstrap resampling.
    RESULTS: Among the 176 patients included, 33 (18.75 %) experienced recurrence, while 143 did not. Independent predictors for recurrence included HPV types, history of anal intercourse, and the number of CO2 laser treatments received. Incorporating these predictors, the nomogram demonstrated a superior diagnostic performance (area under the curve = 0.881, 95 % CI: 0.818-0.935) and a significant net benefit in decision curve analysis.
    CONCLUSIONS: The nomogram accurately predicts the risk of recurrence in HIV-negative patients with anal CA following ALA-PDT. It offers a valuable tool for guiding preoperative clinical decision-making and establishing personalized treatment strategies to minimize the risk of relapse.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    全球,宫颈癌(CC)是女性癌症相关死亡的第二大主要原因。人乳头瘤病毒(HPV)感染是CC的主要原因。HPV持续感染占所有CC病例的90%。人乳头瘤病毒疫苗具有预防数百万女性和男性HPV相关感染的巨大潜力。当前的研究旨在评估在DebreBerhan市有合格女儿的妇女对HPV疫苗及其决定因素的知识和看法,埃塞俄比亚。
    从2023年4月2日至2023年5月15日进行了横断面研究。采用多阶段抽样程序招募了607名女性参与者。描述性统计数据用于总结社会人口统计数据。进行单变量和多变量二元逻辑回归分析以测量因变量和自变量之间的关联。P值<0.05被认为是统计学上显著的。
    超过四分之三的参与者,目前有479人(80%)结婚,243名(40.1%)拥有文凭或高等教育水平。在456(75.12)名参与者中,他们有关于宫颈癌的信息。对于449名(73.9%)的参与者,电视是主要证据。352名参与者中的大多数(59.99%)知道HPV疫苗可以提供给9-14岁的女性儿童。只有215名(35.4%)的参与者认为HPV疫苗是安全有效的。与不读写的研究参与者相比,具有学位及以上文化程度的女性对HPV疫苗有良好知识的可能性约为9倍(AOR=9.21;95%CI=2.82-12.16;p=0.004)。在这项研究之前没有关于HPV疫苗的信息的女性对HPV疫苗有积极看法的可能性比对HPV疫苗有早期信息的参与者低80%(AOR=0.8;95CI=0.63-0.49;P=003)。
    女性对HPV疫苗的知识和观念很差。产妇的婚姻状况,年龄,和HPV疫苗的信息是唯一的预测女性的HPV疫苗的知识。
    UNASSIGNED: Globally, cervical cancer(CC) is the second most commonly diagnosed cancer and the fourth leading cause of cancer-related deaths in women. Human papillomavirus (HPV) infection is the leading cause of CC. Persistent infection with HPV accounts for 90% of all CC cases. The human papillomavirus vaccine has the great potential to prevent HPV-related infections for millions of women and men. The current study aimed to assess knowledge and perceptions towards the HPV vaccine and its determinants among women who have eligible daughters in Debre Berhan City, Ethiopia.
    UNASSIGNED: A cross-sectional study was conducted from April 2, 2023, to May 15, 2023. A multistage sampling procedure was used to recruit 607 women participants. Descriptive statistics were used to summarize socio-demographic data. Univariable and multivariable binary logistic regression analyses were performed to measure the associations between the dependent and independent variables. A p-value of <0.05 was considered statistically significant.
    UNASSIGNED: More than three-fourths of the participants, 479 individuals (80%) were currently married, and 243(40.1%) had a diploma or higher education level. Of 456(75.12) participants reported, they had information about cervical cancer. For 449(73.9%) of the participants, television was the main evidence. The majority of 352(59.99%) participants knew the HPV vaccine could be offered to a female child aged 9-14 years old. Only 215(35.4%) participants think the HPV vaccine was safe and effective. Women who had a degree and above educational level were about 9 times more likely to have good knowledge about the HPV vaccine than study participants who did not read and write (AOR=9.21; 95% CI=2.82-12.16; p=0.004). Women who did not have information about the HPV vaccine before this study were about 80% less likely to have a positive perception of the HPV vaccine than participants who had earlier information about the HPV vaccine (AOR=0.8; 95%CI=0.63-0.49; P=003).
    UNASSIGNED: Women had poor knowledge and perceptions about the HPV vaccine. Maternal marital status, age, and having information about the HPV vaccine were the only predictors of women\'s knowledge of the HPV vaccine.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    背景:如果我们要意识到在新西兰Aotearoa引入人乳头瘤病毒(HPV)筛查的好处,就需要公平地获得阴道镜检查服务。我们试点了一个社区阴道镜诊所,位于城市marae健康诊所。
    目的:描述wahine(女性)参加基于marae的阴道镜诊所的经历。
    方法:对34人的账户进行了深入的反身主题分析。
    结果:从wāhine在诊所就诊的经验中确定了五个主题。与当地诊所如何支持访问相关的三个主题:每个人都很热情和友好,环境熟悉且非临床,可进入诊所.第四个主题与这对机构的贡献有关。第五个主题涉及关于告知持续提供阴道镜检查服务的意见。这些经验反映了marae健康诊所的原则和价值观。Wāhine描述了他们进入诊所后立即受到照顾的感觉。因为诊所是当地的,对于一些在他们的Marae工作的人来说,这是一个已知的空间,他们知道体验将是安全的。欢迎Whānau提供儿童玩耍的空间。在当地意味着需要管理的物流更少,所有这些都支持访问。
    结论:通过提供文化上安全和可访问的阴道镜来优先考虑wahine是可行的。它有可能有助于消除Aotearoa的宫颈癌,新西兰。
    BACKGROUND: Equitable access to colposcopy services is required if we are to realise the benefit of the introduction of human papilloma virus (HPV) screening in Aotearoa New Zealand. We piloted a community colposcopy clinic, co-located at an urban marae health clinic.
    OBJECTIVE: To describe the experiences of wāhine (women) attending the marae-based colposcopy clinic.
    METHODS: An in-depth reflexive thematic analysis from 34 people\'s accounts was undertaken.
    RESULTS: Five themes were identified from the experiences of wāhine attending the clinic. Three themes related to how having a local clinic supported access: everyone was welcoming and friendly, the environment was familiar and non-clinical and the clinic was accessible. The fourth theme related to how this contributed to agency. A fifth theme relates to wāhine views about informing the ongoing provision of colposcopy services. The experiences reflected the principles and values practised at the marae health clinic. Wāhine described feeling cared for as soon as they entered the clinic. As the clinic was local, and for some based at their marae, it was a known space where they knew the experience would be safe. Whānau were welcome with spaces for children to play. Being local meant there were fewer logistics to manage, all of which supported access.
    CONCLUSIONS: Prioritising wāhine through the provision of culturally safe and accessible colposcopy is feasible. It has the potential to contribute to the elimination of cervical cancer in Aotearoa, New Zealand.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    疫苗接种是人类乳头状瘤病毒(HPV)感染一级预防的主要策略。导致不同的病理状况,癌症,在男性和女性。然而,到目前为止,青少年及其父母对HPV疫苗的了解仍然很低.这个准实验的目的,多中心研究是评估数字教育干预的有效性,由包括社区护士在内的多学科医疗保健团队进行,为了增加青少年的HPV疫苗接种,他们的知识,自我效能感,感觉和参与HPV疫苗决策,和父母的疫苗接种犹豫。该研究将在学生(及其父母)中进行,年龄在11至13岁之间,在意大利的中学。经过验证的问卷将在基线(T0)和数字教育干预(T1)后3个月对学生和家长进行管理。这些发现可能有助于评估和深化设计和实施教育干预措施的方法,嵌入在学校环境中,这可以促进在更广泛的青年健康促进过程中取得成果。
    Vaccination is the principal strategy for primary prevention of infection by Human Papilloma Virus (HPV), which causes different pathological conditions, up to cancer, in both males and females. However, to date, knowledge among adolescents and their parents about the HPV vaccine is still low. The aim of this quasi-experimental, multicenter study is to assess the effectiveness of a digital educational intervention, conducted by a multidisciplinary health-care team including a Community Nurse, to increase adolescents\' HPV vaccination uptake, their knowledge, self-efficacy, feelings and involvement in HPV vaccine decision-making, and parents\' vaccination hesitancy. The study will be carried out among a population of students (and their parents), aged between 11 and 13, at secondary schools in Italy. Validated questionnaires will be administered to both students and parents at baseline (T0) and 3 months after a digital educational intervention (T1). The findings may be useful in evaluating and deepening a methodology for designing and implementing educational interventions, embedded in the school setting, that could promote the achievement of outcomes within the broader process of youth\'s health promotion.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    背景:本研究旨在评估宫颈上皮内瘤变(CIN)患者行环形电切术(LEEP)后的长期肿瘤和产科结局,并探讨复发和早产的危险因素。
    方法:这项回顾性队列研究包括2011年至2019年期间接受LEEPforCIN2-3的患者。人口统计信息,组织病理学发现,术后细胞学,收集和分析人乳头瘤病毒(HPV)状态。采用Cox比例风险模型和Kaplan-Meier曲线及对数秩检验进行危险因素分析。
    结果:共385例接受LEEP治疗的患者进行分析。治疗失败,包括手术后复发或残留疾病,在13.5%的患者中观察到。手术切缘阳性和术后HPV检测是CIN1+复发或残留疾病的独立危险因素(HR1.948[95CI1.020-3.720],p=0.043,HR6.848[95CI3.652-12.840],p值分别<0.001)。31名患者随后在LEEP术后分娩,LEEP和分娩之间的持续时间与早产相关的并发症显著相关,如短子宫颈,早产,和早产胎膜早破(p=0.009)。然而,只有早产史与早产有关.
    结论:LEEP术后HPV阳性状态和切缘状态被确定为接受LEEP的CIN患者治疗失败的独立危险因素。然而,结合这两个因素并不能提高复发的预测准确性.
    BACKGROUND: The present study aimed to evaluate the long-term oncological and obstetric outcomes following the loop electrosurgical excision procedure (LEEP) in patients with cervical intraepithelial neoplasia (CIN) and investigate the risk factors for recurrence and preterm birth.
    METHODS: This retrospective cohort study included patients who underwent LEEP for CIN 2-3 between 2011 and 2019. Demographic information, histopathological findings, postoperative cytology, and human papillomavirus (HPV) status were collected and analyzed. The Cox proportional hazards model and Kaplan-Meier curves with the log-rank test were used for risk factor analysis.
    RESULTS: A total of 385 patients treated with the LEEP were analyzed. Treatment failure, including recurrence or residual disease following surgery, was observed in 13.5% of the patients. Positive surgical margins and postoperative HPV detection were independent risk factors for CIN1 + recurrence or residual disease (HR 1.948 [95%CI 1.020-3.720], p = 0.043, and HR 6.848 [95%CI 3.652-12.840], p-value < 0.001, respectively). Thirty-one patients subsequently delivered after LEEP, and the duration between LEEP and delivery was significantly associated with preterm-related complications, such as a short cervix, preterm labor, and preterm premature rupture of the membrane (p = 0.009). However, only a history of preterm birth was associated with preterm delivery.
    CONCLUSIONS: Positive HPV status after LEEP and margin status were identified as independent risk factors for treatment failure in patients with CIN who underwent LEEP. However, combining these two factors did not improve the prediction accuracy for recurrence.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

公众号