METHODS: The study conducted among 251 WLWH and 268 women with negative HIV status enrolled from gynecological clinics in primary health care centers from nine Egyptian governorates. Data was collected from participants using a structured interview questionnaire and cervical samples were collected for HPV DNA detection and genotyping.
RESULTS: The overall prevalence of HPV infection was 13.5%, 3.4% among women with HIV negative status and 24.4% among WLWH. HR-HPVs other than genotype 16 and 18 were isolated from 71% of infected women. Woman\'s age, age at first marriage, number of lifetime marriages and drug addiction are significant predictors for HPV infection (odds 0.96, 0.91, 2.06, 2.01 respectively).
CONCLUSIONS: HPV infection is more prevalent among WLWH. Infection with HR-HPV other than genotype 16 and 18 was the most prevalent among infected women in both groups. Young age, early life sexual activity, having more than one sexual partner during the life time, and drug addiction are independent predictors for HPV infection. Having a husband who has had other sexual partners is significantly associated with infection.
方法:这项研究在埃及9个省初级保健中心妇科诊所招募的251名WLWH和268名HIV阴性状态妇女中进行。使用结构化访谈问卷从参与者收集数据,并收集宫颈样本用于HPVDNA检测和基因分型。
结果:HPV感染的总体患病率为13.5%,感染艾滋病毒阴性的妇女中占3.4%,WLWH中占24.4%。从71%的受感染妇女中分离出基因型16和18以外的HR-HPV。女人的年龄,初婚年龄,终生婚姻数量和药物成瘾是HPV感染的重要预测因素(分别为赔率0.96,0.91,2.06,2.01).
结论:HPV感染在WLWH中更为普遍。除基因型16和18以外的HR-HPV感染在两组中的感染妇女中最为普遍。年轻的年龄,早期性生活活动,一生中有不止一个性伴侣,药物成瘾是HPV感染的独立预测因子。有一个有其他性伴侣的丈夫与感染密切相关。