PDF(Pubmed)
Abstract：
BACKGROUND: HPV is considered the most common sexually transmitted infection. It is responsible of 70% of cervical cancers worldwide. HIV infection is associated with increased rates of HPV infection. Women Living With HIV (WLWH) are 6 times at greater risk of developing cervical cancer. The current study aimed to estimate prevalence and identify genotypes of HPV infection among WLWH in Egypt compared to women with negative HIV status and determine associated risk factors.
METHODS: The study conducted among 251 WLWH and 268 women with negative HIV status enrolled from gynecological clinics in primary health care centers from nine Egyptian governorates. Data was collected from participants using a structured interview questionnaire and cervical samples were collected for HPV DNA detection and genotyping.
RESULTS: The overall prevalence of HPV infection was 13.5%, 3.4% among women with HIV negative status and 24.4% among WLWH. HR-HPVs other than genotype 16 and 18 were isolated from 71% of infected women. Woman\'s age, age at first marriage, number of lifetime marriages and drug addiction are significant predictors for HPV infection (odds 0.96, 0.91, 2.06, 2.01 respectively).
CONCLUSIONS: HPV infection is more prevalent among WLWH. Infection with HR-HPV other than genotype 16 and 18 was the most prevalent among infected women in both groups. Young age, early life sexual activity, having more than one sexual partner during the life time, and drug addiction are independent predictors for HPV infection. Having a husband who has had other sexual partners is significantly associated with infection.
METHODS: The study conducted among 251 WLWH and 268 women with negative HIV status enrolled from gynecological clinics in primary health care centers from nine Egyptian governorates. Data was collected from participants using a structured interview questionnaire and cervical samples were collected for HPV DNA detection and genotyping.
RESULTS: The overall prevalence of HPV infection was 13.5%, 3.4% among women with HIV negative status and 24.4% among WLWH. HR-HPVs other than genotype 16 and 18 were isolated from 71% of infected women. Woman\'s age, age at first marriage, number of lifetime marriages and drug addiction are significant predictors for HPV infection (odds 0.96, 0.91, 2.06, 2.01 respectively).
CONCLUSIONS: HPV infection is more prevalent among WLWH. Infection with HR-HPV other than genotype 16 and 18 was the most prevalent among infected women in both groups. Young age, early life sexual activity, having more than one sexual partner during the life time, and drug addiction are independent predictors for HPV infection. Having a husband who has had other sexual partners is significantly associated with infection.
摘要：
背景：HPV被认为是最常见的性传播感染。它负责全世界70%的宫颈癌。HIV感染与HPV感染率增加有关。感染艾滋病毒（WLWH）的女性患宫颈癌的风险是其6倍。本研究旨在评估埃及WLWH与HIV阴性妇女相比的流行率和确定HPV感染的基因型，并确定相关的危险因素。
方法：这项研究在埃及9个省初级保健中心妇科诊所招募的251名WLWH和268名HIV阴性状态妇女中进行。使用结构化访谈问卷从参与者收集数据，并收集宫颈样本用于HPVDNA检测和基因分型。
结果：HPV感染的总体患病率为13.5％，感染艾滋病毒阴性的妇女中占3.4%，WLWH中占24.4%。从71％的受感染妇女中分离出基因型16和18以外的HR-HPV。女人的年龄，初婚年龄,终生婚姻数量和药物成瘾是HPV感染的重要预测因素(分别为赔率0.96,0.91,2.06,2.01).
结论：HPV感染在WLWH中更为普遍。除基因型16和18以外的HR-HPV感染在两组中的感染妇女中最为普遍。年轻的年龄,早期性生活活动，一生中有不止一个性伴侣，药物成瘾是HPV感染的独立预测因子。有一个有其他性伴侣的丈夫与感染密切相关。
方法：这项研究在埃及9个省初级保健中心妇科诊所招募的251名WLWH和268名HIV阴性状态妇女中进行。使用结构化访谈问卷从参与者收集数据，并收集宫颈样本用于HPVDNA检测和基因分型。
结果：HPV感染的总体患病率为13.5％，感染艾滋病毒阴性的妇女中占3.4%，WLWH中占24.4%。从71％的受感染妇女中分离出基因型16和18以外的HR-HPV。女人的年龄，初婚年龄,终生婚姻数量和药物成瘾是HPV感染的重要预测因素(分别为赔率0.96,0.91,2.06,2.01).
结论：HPV感染在WLWH中更为普遍。除基因型16和18以外的HR-HPV感染在两组中的感染妇女中最为普遍。年轻的年龄,早期性生活活动，一生中有不止一个性伴侣，药物成瘾是HPV感染的独立预测因子。有一个有其他性伴侣的丈夫与感染密切相关。
