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Abstract：
UNASSIGNED: Cervical cancer is the leading cause of gynaecological cancer death among women in developing countries and the most preventable of all gynaecological cancers as its infectious aetiological agent, human papillomavirus (HPV), is known. The knowledge of HPV serotype distribution in a sub-region is key to the implementation of an appropriate HPV vaccination programme.
UNASSIGNED: To assess the prevalence of HPV-DNA, serotypes and risk-determinants among women with invasive cervical cancer (ICC) in Katsina State, Northwestern Nigeria.
UNASSIGNED: This was a cross-sectional, multicenter study involving Federal Teaching Hospital Katsina, General Hospital Katsina and Turai Yar\'adua Maternal and Child Hospital Katsina, Nigeria. Sixty-three women with histologically confirmed cervical cancer who fulfilled the criteria were recruited into the study. Tissue blocks with a confirmed diagnosis of ICC were taken to DNA Labs Kaduna for HPV-deoxyribonucleotide acid detection and typing. An interviewer-administered questionnaire developed for the study was used to obtain socio-demographic, reproductive characteristics and the other risk factors for HPV acquisition and persistence.
UNASSIGNED: The HPV-positivity rate in ICC was 95.5% while the prevalence of high-risk HPV (Hr-HPV)-DNA in the specimen was 54.6% with 13 HPV-serotypes detected, 9 Hr-HPV types (16,18,31,33,35,45,51,56,82) and 4 low-risk HPV types (6,44,81,89). The most commonly detected HPV serotype among women with a single HPV infection was HPV 81 (40.9%) followed by HPV 16 (28.8%). However, HPV 16 was the most common serotype among those with multiple HPV infections. Prevalence of other detected serotypes were HPV 31 (24.2%), 33 (24.2%), HPV 18 (10.6%), HPV 35 (3.0%), HPV 45 (9.1%), HPV 44 (1.5%), HPV 51 (3.0%), HPV 56 (3.0%), HPV 82 (1.5%), HPV 89 (1.5%) and HPV 6 (1.5%). Forty-four out of 63 women (69.8%) had a single HPV infection, 19 (30.2%) had multiple HPV infections and 15 (24.3%) were co-infected with HPV 16/31/33. There was a statistically significant association between HPV 16 and squamous cell carcinoma (SCC).
UNASSIGNED: The study demonstrates a prevalence of HPV-DNA as 95.5% among women with ICC. The most commonly detected HPV serotype was HPV 81 seen in 41% which was an uncommon finding. Furthermore, statistically significant associations between HPV serotypes 16 and 82 with SCC were detected.
UNASSIGNED: To assess the prevalence of HPV-DNA, serotypes and risk-determinants among women with invasive cervical cancer (ICC) in Katsina State, Northwestern Nigeria.
UNASSIGNED: This was a cross-sectional, multicenter study involving Federal Teaching Hospital Katsina, General Hospital Katsina and Turai Yar\'adua Maternal and Child Hospital Katsina, Nigeria. Sixty-three women with histologically confirmed cervical cancer who fulfilled the criteria were recruited into the study. Tissue blocks with a confirmed diagnosis of ICC were taken to DNA Labs Kaduna for HPV-deoxyribonucleotide acid detection and typing. An interviewer-administered questionnaire developed for the study was used to obtain socio-demographic, reproductive characteristics and the other risk factors for HPV acquisition and persistence.
UNASSIGNED: The HPV-positivity rate in ICC was 95.5% while the prevalence of high-risk HPV (Hr-HPV)-DNA in the specimen was 54.6% with 13 HPV-serotypes detected, 9 Hr-HPV types (16,18,31,33,35,45,51,56,82) and 4 low-risk HPV types (6,44,81,89). The most commonly detected HPV serotype among women with a single HPV infection was HPV 81 (40.9%) followed by HPV 16 (28.8%). However, HPV 16 was the most common serotype among those with multiple HPV infections. Prevalence of other detected serotypes were HPV 31 (24.2%), 33 (24.2%), HPV 18 (10.6%), HPV 35 (3.0%), HPV 45 (9.1%), HPV 44 (1.5%), HPV 51 (3.0%), HPV 56 (3.0%), HPV 82 (1.5%), HPV 89 (1.5%) and HPV 6 (1.5%). Forty-four out of 63 women (69.8%) had a single HPV infection, 19 (30.2%) had multiple HPV infections and 15 (24.3%) were co-infected with HPV 16/31/33. There was a statistically significant association between HPV 16 and squamous cell carcinoma (SCC).
UNASSIGNED: The study demonstrates a prevalence of HPV-DNA as 95.5% among women with ICC. The most commonly detected HPV serotype was HPV 81 seen in 41% which was an uncommon finding. Furthermore, statistically significant associations between HPV serotypes 16 and 82 with SCC were detected.
摘要：
宫颈癌是发展中国家妇女妇科癌症死亡的主要原因，也是所有妇科癌症中最可预防的传染性病原体，人乳头瘤病毒（HPV），是已知的。分区域中HPV血清型分布的知识是实施适当的HPV疫苗接种计划的关键。
■为了评估HPV-DNA的患病率，Katsina州浸润性宫颈癌（ICC）女性的血清型和风险决定因素，尼日利亚西北部。
■这是一个横截面，涉及联邦教学医院Katsina的多中心研究，总医院Katsina和TuraiYar\'adua妇幼保健院Katsina,尼日利亚。63名经组织学证实符合该标准的宫颈癌妇女被招募到研究中。已确认ICC诊断的组织块被带到DNALabsKaduna进行HPV脱氧核糖核苷酸检测和分型。为这项研究开发的面试官管理的问卷被用来获得社会人口统计，生殖特征以及HPV获取和持续的其他危险因素。
■ICC中的HPV阳性率为95.5％，而标本中的高危型HPV（Hr-HPV）-DNA的患病率为54.6％，检测到13种HPV血清型，9个Hr-HPV类型（16,18,31,33,35,45,51,56,82）和4个低风险HPV类型（6,44,81,89）。在单一HPV感染的女性中最常见的HPV血清型是HPV81（40.9％），其次是HPV16（28.8％）。然而,HPV16是具有多种HPV感染的那些中最常见的血清型。其他检测到的血清型为HPV31（24.2%），33（24.2%），HPV18（10.6%），HPV35（3.0%），HPV45（9.1％），HPV44（1.5％），HPV51（3.0%），HPV56（3.0%），HPV82（1.5％），HPV89（1.5％）和HPV6（1.5％）。63名女性中有44名（69.8％）患有单一HPV感染，19例（30.2%）有多重HPV感染，15例（24.3%）与HPV16/31/33共感染。HPV16与鳞状细胞癌（SCC）之间存在统计学上的显着关联。
该研究表明，ICC女性中HPV-DNA的患病率为95.5％。最常见的HPV血清型是41％的HPV81，这是一个罕见的发现。此外，在HPV血清型16和82与SCC之间检测到有统计学意义的关联.
■为了评估HPV-DNA的患病率，Katsina州浸润性宫颈癌（ICC）女性的血清型和风险决定因素，尼日利亚西北部。
■这是一个横截面，涉及联邦教学医院Katsina的多中心研究，总医院Katsina和TuraiYar\'adua妇幼保健院Katsina,尼日利亚。63名经组织学证实符合该标准的宫颈癌妇女被招募到研究中。已确认ICC诊断的组织块被带到DNALabsKaduna进行HPV脱氧核糖核苷酸检测和分型。为这项研究开发的面试官管理的问卷被用来获得社会人口统计，生殖特征以及HPV获取和持续的其他危险因素。
■ICC中的HPV阳性率为95.5％，而标本中的高危型HPV（Hr-HPV）-DNA的患病率为54.6％，检测到13种HPV血清型，9个Hr-HPV类型（16,18,31,33,35,45,51,56,82）和4个低风险HPV类型（6,44,81,89）。在单一HPV感染的女性中最常见的HPV血清型是HPV81（40.9％），其次是HPV16（28.8％）。然而,HPV16是具有多种HPV感染的那些中最常见的血清型。其他检测到的血清型为HPV31（24.2%），33（24.2%），HPV18（10.6%），HPV35（3.0%），HPV45（9.1％），HPV44（1.5％），HPV51（3.0%），HPV56（3.0%），HPV82（1.5％），HPV89（1.5％）和HPV6（1.5％）。63名女性中有44名（69.8％）患有单一HPV感染，19例（30.2%）有多重HPV感染，15例（24.3%）与HPV16/31/33共感染。HPV16与鳞状细胞癌（SCC）之间存在统计学上的显着关联。
该研究表明，ICC女性中HPV-DNA的患病率为95.5％。最常见的HPV血清型是41％的HPV81，这是一个罕见的发现。此外，在HPV血清型16和82与SCC之间检测到有统计学意义的关联.
