■已经报道了人类疱疹病毒(HHVs)与心血管疾病/死亡率之间的关联,但证据不一致.我们调查了3种常见疱疹病毒与(1)意外中风或心肌梗塞(MI)和(2)全因死亡率之间的关联。
■我们纳入了来自英国生物库传染病试点研究的参与者,他们在进入队列(2006-2010)时对1型单纯疱疹病毒(HSV1)进行了有效的血清抗体(IgG)测量,水痘带状疱疹病毒(VZV),和巨细胞病毒(CMV)。截至2019年12月30日的关联医院和死亡率记录提供了有关(1)首次卒中或MI和(2)全因死亡率的信息。来自Cox比例风险回归模型的风险比(HR)用于评估(1)HHV血清阳性之间的关系,(2)HHV滴度和卒中/MI,和死亡结果。完全调整的模型考虑了社会人口统计信息(年龄,性别,种族,教育,剥夺五分之一,出生地,人口密度),基线合并症(包括糖尿病和高血压),吸烟状况,身体质量指数,和血清胆固醇。
■在9429名研究参与者中(56%为女性,95%白色中位年龄58岁),41%对所有3种HHV呈血清阳性。人类疱疹病毒血清阳性与卒中/MI无关(完全校正的HR和95%置信区间[CI]:HSV1=0.93[CI,0.72-1.22],VZV=0.78[CI,0.51-1.20],CMV=0.91[CI,0.71-1.16])或全因死亡率(HSV1=1.21[CI,1.00-1.47],VZV=0.79[CI,0.58-1.07],CMV=0.90[CI,0.76-1.06])。人类疱疹病毒滴度与结果无关。
■在这个以白人为主的英国生物库子集中,HHV血清阳性和滴度均与卒中/MI或全因死亡率无关.
UNASSIGNED: Associations between human herpesviruses (HHVs) and cardiovascular disease/mortality have been reported, but evidence is inconsistent. We investigated associations between 3 common herpesviruses and (1) incident stroke or myocardial infarction (MI) and (2) all-cause mortality.
UNASSIGNED: We included participants from the UK Biobank Infectious Disease pilot
study with valid serum antibody (IgG) measurements taken at cohort entry (2006-2010) for herpes simplex virus type 1 (HSV1), varicella zoster virus (VZV), and cytomegalovirus (CMV). Linked hospital and mortality records up to December 30 2019 provided information on rates of (1) incident first stroke or MI and (2) all-cause mortality. Hazard ratios (HRs) from Cox proportional hazards regression models were used to assess relationships between (1) HHV seropositivity, (2) HHV titer and incident stroke/MI, and death outcomes. Fully adjusted models accounted for sociodemographic information (age, sex, ethnicity, education, deprivation quintile, birthplace, population density), baseline comorbidities (including diabetes and hypertension), smoking status, body mass index, and serum cholesterol.
UNASSIGNED: Of 9429
study participants (56% female, 95% White, median age 58 years), 41% were seropositive for all 3 HHVs. Human herpesvirus seropositivity was not associated with stroke/MI (fully adjusted HRs and 95% confidence intervals [CIs]: HSV1 = 0.93 [CI, 0.72-1.22], VZV = 0.78 [CI, 0.51-1.20], CMV = 0.91 [CI, 0.71-1.16]) or all-cause mortality (HSV1 = 1.21 [CI, 1.00-1.47], VZV = 0.79 [CI, 0.58-1.07], CMV = 0.90 [CI, 0.76-1.06]). Human herpesvirus titers were not associated with outcomes.
UNASSIGNED: In this mostly White UK Biobank subset, neither HHV seropositivity nor titers were associated with stroke/MI or all-cause mortality.