背景:继发于颅内动脉瘤(IA)的蛛网膜下腔出血是高死亡率事件。这些神经血管疾病起因于局部和全身性炎症,最终导致血管壁变化。它们也可能与慢性病毒感染有关,如人类疱疹病毒(HHV),尤其是EB病毒(EBV),这导致了几种医疗状况。这是IA患者中HHV脱氧核糖核酸(DNA)存在的首次描述。
方法:一名意识水平下降的61岁女性接受放射学检查,发现前交通动脉有一个10mm破裂的动脉瘤。进行了显微外科手术夹以明确治疗动脉瘤,并且没有手术并发症。对获得的材料进行分子分析,发现动脉瘤壁中存在EBVDNA。患者入院21天后因临床并发症和脑肿胀死亡。
结论:这是对IA患者中疱疹病毒DNA的首次描述,在我们2.8%的数据中呈现。这些发现强调病毒感染可能有助于病理生理学,并且是IA形成的额外风险因素。programming,通过调节慢性感染的血管壁炎症和结构变化而破裂。
BACKGROUND: Subarachnoid hemorrhages secondary to intracranial aneurysms (IAs) are events of high mortality. These neurological vascular diseases arise from local and systemic inflammation that culminates in vessel wall changes. They may also have a possible relationship with chronic viral infections, such as human herpesvirus (HHV), and especially Epstein-Barr virus (EBV), which causes several medical conditions. This is the first description of the presence of HHV deoxyribonucleic acid (DNA) in a patient with IA.
METHODS: A 61-year-old woman with a downgraded level of consciousness underwent radiological examinations that identified a 10-mm ruptured aneurysm in the anterior communicating artery. A microsurgery clip was performed to definitively treat the aneurysm and occurred without surgical complications. Molecular analysis of the material obtained revealed the presence of EBV DNA in the aneurysm wall. The patient died 21 days after admission due to clinical complications and brain swelling.
CONCLUSIONS: This is the first description of the presence of herpesvirus DNA in a patient with IA, presented in 2.8% of our data. These findings highlight that viral infection may contribute to the pathophysiology and is an additional risk factor for IA formation, progression, and rupture by modulating vessel wall inflammation and structural changes in chronic infections.