healthcare facilities

医疗保健设施
  • 文章类型: Preprint
    环境卫生服务(例如,水,卫生,卫生,清洁,废物管理)对改善健康结果和加强卫生系统至关重要,但覆盖差距仍然存在。世界卫生组织和联合国儿童基金会开发了WASHFIT,质量改进工具,帮助评估和改善环境卫生服务。有53个国家采用了它。然而,几乎没有证据表明它的有效性。本系统评价评估WASHFIT是否改善了环境卫生服务或相关的健康结果和影响。
    我们进行了数据库搜索,以确定相关研究并提取研究设计的数据,医疗机构的特点,和输入,活动,输出,结果,以及与WASHFIT相关的影响。我们使用逻辑模型框架和叙事综合对研究结果进行了总结。
    我们纳入了31项研究。大多数投入和活动都是定性描述的。23项研究报告了定量产出,主要WASHFIT指标得分,以及受过WASHFIT培训的人员。九项研究报告了纵向数据,表明在整个WASHFIT实施过程中这些输出的变化。六项研究报告了定量结果测量;其余的定性或根本没有描述结果。共同成果包括为环境卫生服务分配资金,社区参与,和政府合作,知识的变化,态度,或医护人员的做法,病人,或社区成员,和政策变化。没有研究直接测量影响或评估WASHFIT对严格对照组的影响。
    现有证据不足以评估WASHFIT对输出的影响,结果,和影响。需要进一步努力,全面确定实施WASHFIT所需的投入和活动,并在产出变化之间建立具体联系,结果,和影响。通过更全面地报告WASHFIT评估和利用健康管理信息系统中的健康影响数据,存在改善证据的短期机会。从长远来看,我们推荐实验研究。这些证据对于确保为WASHFIT实施投入的资金得到经济有效的利用,并且随着WASHFIT的使用和影响力的不断增长,适应和完善WASHFIT的机会得到充分实现非常重要。
    WASHFIT非常有影响力,但是对其有效性知之甚少。我们回顾了WASHFIT对环境卫生服务输出和健康影响的影响九项研究纵向测量了输出;没有任何直接测量健康影响的研究将WASHFIT的性能与严格对照组进行比较。证据不足以评估WASHFIT对输出或健康影响的影响。
    UNASSIGNED: Environmental health services (e.g., water, sanitation, hygiene, cleaning, waste management) in healthcare facilities are important to improve health outcomes and strengthen health systems, but coverage gaps remain. The World Health Organization and United Nations Children\'s Fund developed WASH FIT, a quality improvement tool, to help assess and improve environmental health services. Fifty-three countries have adopted it. However, there is little evidence of its effectiveness. This systematic review evaluates whether WASH FIT improves environmental health services or associated health outcomes and impacts.
    UNASSIGNED: We conducted database searches to identify relevant studies and extracted data on study design, healthcare facility characteristics, and inputs, activities, outputs, outcomes, and impacts associated with WASH FIT. We summarized the findings using a logic model framework and narrative synthesis.
    UNASSIGNED: We included 31 studies in the review. Most inputs and activities were described qualitatively. Twenty-three studies reported quantitative outputs, primary WASH FIT indicator scores, and personnel trained on WASH FIT. Nine studies reported longitudinal data demonstrating changes in these outputs throughout WASH FIT implementation. Six studies reported quantitative outcomes measurements; the remainder described outcomes qualitatively or not at all. Common outcomes included allocated funding for environmental health services, community engagement, and government collaboration, changes in knowledge, attitudes, or practices among healthcare staff, patients, or community members, and policy changes. No studies directly measured impacts or evaluated WASH FIT against a rigorous control group.
    UNASSIGNED: Available evidence is insufficient to evaluate WASH FIT\'s effects on outputs, outcomes, and impacts. Further effort is needed to comprehensively identify the inputs and activities required to implement WASH FIT and to draw specific links between changes in outputs, outcomes, and impacts. Short-term opportunities exist to improve evidence by more comprehensive reporting of WASH FIT assessments and exploiting data on health impacts within health management information systems. In the long term, we recommend experimental studies. This evidence is important to ensure that funding invested for WASH FIT implementation is used cost-effectively and that opportunities to adapt and refine WASH FIT are fully realized as it continues to grow in use and influence.
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  • 文章类型: Meta-Analysis
    中风患者的压疮风险是一个重要的问题,影响他们的康复和生活质量。本系统评价和荟萃分析探讨脑卒中患者压疮的患病率和危险因素。将医疗机构中的医疗设施与家庭或非临床环境中的医疗设施进行比较。该研究旨在阐明不同的护理设置如何影响压疮的发展,作为跨不同医疗保健环境的患者护理质量和管理的关键指标。按照PRISMA准则,在PubMed进行了全面搜索,Embase,WebofScience和Cochrane图书馆。纳入标准包括对不同背景的卒中患者的研究,报告压疮的发生率或患病率。排除标准包括非中风患者,非原创性研究和数据不完整的研究。纽卡斯尔-渥太华量表用于质量评估,统计分析涉及固定效应和随机效应模型,取决于观察到的异质性。最初总共确定了1542篇文章,11项研究符合纳入标准。这些研究表现出显著的异质性,需要使用随机效应模型。在没有家庭医疗服务的患者中,压力性损伤的合并患病率为9.53%,在有医疗服务的患者中为2.64%。灵敏度分析证实了这些结果的稳定性,漏斗图分析和Egger线性回归检验未发现显著的发表偏倚。荟萃分析强调了中风患者压力损伤的风险增加,尤其是出院后。它呼吁医疗保健提供者共同努力,政策制定者和护理人员实施针对不同护理环境具体需求的针对性策略。未来的研究应集中在开发和评估干预措施,以有效地整合到常规护理中并减少中风患者压力损伤的发生率。
    The risk of pressure ulcers in stroke patients is a significant concern, impacting their recovery and quality of life. This systematic review and meta-analysis investigate the prevalence and risk factors of pressure ulcers in stroke patients, comparing those in healthcare facilities with those in home-based or non-clinical environments. The study aims to elucidate how different care settings affect the development of pressure ulcers, serving as a crucial indicator of patient care quality and management across diverse healthcare contexts. Following PRISMA guidelines, a comprehensive search was conducted across PubMed, Embase, Web of Science and the Cochrane Library. Inclusion criteria encompassed studies on stroke patients in various settings, reporting on the incidence or prevalence of pressure ulcers. Exclusion criteria included non-stroke patients, non-original research and studies with incomplete data. The Newcastle-Ottawa scale was used for quality assessment, and statistical analyses involved both fixed-effect and random-effects models, depending on the heterogeneity observed. A total of 1542 articles were initially identified, with 11 studies meeting the inclusion criteria. The studies exhibited significant heterogeneity, necessitating the use of a random-effects model. The pooled prevalence of pressure injuries was 9.53% in patients without family medical services and 2.64% in patients with medical services. Sensitivity analysis confirmed the stability of these results, and no significant publication bias was detected through funnel plot analysis and Egger\'s linear regression test. The meta-analysis underscores the heightened risk of pressure injuries in stroke patients, especially post-discharge. It calls for concerted efforts among healthcare providers, policymakers and caregivers to implement targeted strategies tailored to the specific needs of different care environments. Future research should focus on developing and evaluating interventions to effectively integrate into routine care and reduce the incidence of pressure injuries in stroke patients.
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  • 文章类型: Journal Article
    苏丹医疗保健提供者(HCP)经历的工作场所暴力已经风靡一时,在国外驾驶许多HCP。全球范围内,HCP已将工作场所暴力视为其临床工作不可或缺的现象,导致事件漏报。本研究回顾了原因并探讨了该现象的解决方案。搜索策略是使用包括PubMed在内的互联网资源进行的,Embase,谷歌学者,还有Cochrane.对苏丹的引用仅限于公共医疗机构中的HCP。对针对HCP的工作场所暴力的全球状况进行了描述性分析。考虑到苏丹的情况,对未来的干预措施进行了审查和讨论。结果显示了“大流行”现象的性质。工作场所暴力导致医疗保健系统的质量和效率下降,从而影响有效的医疗保健服务。结论是,需要整合多种方法的干预措施,以规避现有的多因素情况。需要对普遍存在的暴力和有罪不罚现象采取法定行动。需要工作场所组织程序来解决患者的需求,这些需求压倒了稀缺资源。HCP培训机构建议采取强有力的教育措施,媒体,和其他利益相关者,以改善医患关系。
    Workplace violence experienced by healthcare providers (HCPs) in Sudan has gone viral, driving many HCPs outside the country. Globally, HCPs have accepted workplace violence as a phenomenon integral to their clinical work, causing an underreporting of incidents. This study reviews the causes and explores solutions for the phenomenon. Search strategies were conducted using internet sources including PubMed, Embase, Google Scholar, and Cochrane. References to Sudan were limited to HCPs in public healthcare facilities. A descriptive analysis was conducted on the global status of workplace violence toward HCPs. Future interventions were examined and discussed considering Sudan\'s circumstances. Results showed the \"pandemic\" nature of the phenomenon. Workplace violence contributes to the deterioration of the quality and efficiency of the healthcare system with consequences for effective healthcare delivery. It is concluded that a multiapproach intervention needs to be integrated to circumvent the standing multifactorial situation. Statutory actions are needed towards the widespread violence and impunity. Workplace organizational procedures are needed to address the patient\'s needs that overwhelm scarce resources. Robust educational efforts are recommended by HCP training bodies, the media, and other stakeholders to improve the doctor/patient relationship.
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  • 文章类型: Journal Article
    背景:这篇综述旨在综合有关感染预防和控制(IPC)干预措施的证据,以预防医护人员(HCW)或初级保健机构内的患者中的医疗保健相关感染(HAI)。
    方法:PubMed,CINAHL,在EMBASE和CENTRAL数据库中搜索了2011-2022年间发表的定量研究。研究选择,使用Cochrane和JoannaBriggs工具进行数据提取和质量评估,通过独立审查进行,并对研究选择进行额外的敏感性检查。
    结果:纳入4项研究。一项随机试验和横断面调查,分别,发现戴N95口罩的HCW与医用口罩的实验室确认流感没有统计学差异(p=0.18),并且结核病(TB)控制措施的实施与TB发病率之间存在显着负相关(p=0.02)。为了预防小手术后的手术部位感染,随机试验发现,非无菌手套(8.7%;95%CI,4.9%-12.6%)不劣于无菌手套(9.3%;95%CI,7.4%-11.1%),预防性抗生素与安慰剂相比无显著差异(p=0.064).所有研究都有很高的偏倚风险。
    结论:用于预防初级保健HAI的IPC干预措施的证据非常有限,不足以提出实践建议。然而,这些发现强调了未来研究的必要性。
    BACKGROUND: This review aimed to synthesize the evidence on infection prevention and control interventions for the prevention of health care-associated infection among health care workers or patients within primary care facilities.
    METHODS: PubMed, CINAHL, EMBASE, and CENTRAL databases were searched for quantitative studies published between 2011 and 2022. Study selection, data extraction, and quality assessment using Cochrane and Joanna Briggs tools, were conducted by independent review with additional sensitivity checking performed on study selection.
    RESULTS: Four studies were included. A randomized trial and a cross-sectional survey, respectively, found no statistical difference in laboratory-confirmed influenza in health care workers wearing N95 versus medical masks (P = .18) and a significant inverse association between the implementation of tuberculosis control measures and tuberculosis incidence (P = .02). For the prevention of surgical site infections following minor surgery, randomized trials found nonsterile gloves (8.7%; 95% confidence interval, 4.9%-12.6%) to be noninferior to sterile gloves (9.3%; 95% confidence interval, 7.4%-11.1%) and no significant difference between prophylactic antibiotics compared to placebo (P = .064). All studies had a high risk of bias.
    CONCLUSIONS: Evidence for infection prevention and control interventions for the prevention of health care-associated infection in primary care is very limited and insufficient to make practice recommendations. Nevertheless, the findings highlight the need for future research.
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  • 文章类型: Journal Article
    医院大楼的室内环境需要较高的室内空气质量(IAQ),以克服患者感染伤口的风险,而不会中断恢复过程。然而,在获得令人满意的IAQ时出现了几个问题,例如不良的通风设计策略,空气交换不足,医疗设备放置不当和开门频率高。本文概述了用于评估医院设施中IAQ的各种方法,尤其是在手术室,隔离室,前厅,术后室,住院室和牙科室。这篇综述表明,实验和数值方法在IAQ评估中都证明了它们的优势。结果表明,气流和颗粒跟踪模型都可能导致不同的颗粒扩散预测。模型选择应取决于模拟结果与实验测量数据的兼容性。还详细讨论了影响颗粒分散特性的主要力和次要力。对颗粒轨迹特性的主要贡献力可以归因于重力和阻力,而与颗粒大小无关。同时,当涉及温度梯度时,可以考虑额外的力,强烈的光源,亚微米颗粒,等。医疗保健机构中涉及的粒径应小于20μm,因为该粒径范围显示出与病毒载量更紧密的关系和更高的保持空气传播的趋势。此外,提出了进一步的研究机会,以反映更现实的方法和对当前评估方法的改进。
    An indoor environment in a hospital building requires a high indoor air quality (IAQ) to overcome patients\' risks of getting wound infections without interrupting the recovery process. However, several problems arose in obtaining a satisfactory IAQ, such as poor ventilation design strategies, insufficient air exchange, improper medical equipment placement and high door opening frequency. This paper presents an overview of various methods used for assessing the IAQ in hospital facilities, especially in an operating room, isolation room, anteroom, postoperative room, inpatient room and dentistry room. This review shows that both experimental and numerical methods demonstrated their advantages in the IAQ assessment. It was revealed that both airflow and particle tracking models could result in different particle dispersion predictions. The model selection should depend on the compatibility of the simulated result with the experimental measurement data. The primary and secondary forces affecting the characteristics of particle dispersion were also discussed in detail. The main contributing forces to the trajectory characteristics of a particle could be attributed to the gravitational force and drag force regardless of particle size. Meanwhile, the additional forces could be considered when there involves temperature gradient, intense light source, submicron particle, etc. The particle size concerned in a healthcare facility should be less than 20 μm as this particle size range showed a closer relationship with the virus load and a higher tendency to remain airborne. Also, further research opportunities that reflect a more realistic approach and improvement in the current assessment approach were proposed.
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  • 文章类型: Journal Article
    目的:在COVID-19大流行期间,寻找补充方法来加强牙科和医疗实践中的手动消毒提高了相关性。我们寻求在手动清洁方案中添加紫外线C(UV-C)消毒的证据,以及是否可以改善表面病原体菌落的对数(log)减少。
    方法:本综述在国际前瞻性系统评价注册中心(PROSPERO)注册,编号为CRD420200193961。咨询了六个电子来源,以寻找在医疗环境中进行的临床试验,其中在干预前后通过菌落形成单位(CFU)计数对病原体进行定量。所有数据库的最后一次咨询是在2021年5月。我们使用修订的Cochrane偏差风险工具(RoB2)评估偏差风险。根据建议分类,证据的确定性是合格的,评价,发展,和评估(等级)方法。
    结果:我们确定了1012条记录,12项研究符合纳入标准。所有包括的研究都报告了UV-C臂的消毒增强;其中大多数报告了大约10到25分钟内1-log到2-log的减少。只有三项研究达到了5-log和6-log的减少。当单独进行手动清洁时,只有两项研究报告使用氯基消毒剂减少了1-log.我们在1项研究中发现了高偏倚风险。证据的确定性分为中等和低。
    结论:证据指出了UV-C技术在减少手动清洁失败方面的有效性,增强表面病原体菌落的对数减少。然而,这些设备的安全性和成功将取决于几个物理和生物因素。明智的项目必须在物理学家或其他受过培训的专业人员的监督下在临床和医疗办公室使用它们之前。
    OBJECTIVE: During the COVID-19 pandemic the search for complementary methods to enhance manual disinfection in dental and medical practices raised relevance. We sought evidence for the addition of ultraviolet-C (UV-C) disinfection to manual cleaning protocols -and whether it improves the logarithmic (log) reduction of surface pathogen colonies.
    METHODS: This review was registered at the International Prospective Register of Systematic Reviews (PROSPERO) under the number CRD420200193961. Six electronic sources were consulted looking for clinical trials performed in healthcare environments in which pathogens were quantified by colony-forming unit (CFU)-enumeration before and after interventions, all databases were last consulted on May 2021. We assessed the risk of bias using an adapted Revised Cochrane Risk of Bias Tool (RoB 2). The certainty of the evidence was qualified according to the Classification of Recommendations, Evaluation, Development, and Evaluation (GRADE) approach.
    RESULTS: We identified 1012 records and 12 studies fulfilled the inclusion criteria. All included studies reported enhanced disinfection in the UV-C arm; most of them reported 1-log to 2-log reduction in approximately 10 to 25 min. Only three studies reached a 5-log and 6-log reduction. When manual cleaning was performed alone, only two studies reported a 1-log reduction using a chlorine-based disinfectant. We detected a high risk of bias in 1 study. Certainty of evidence was classified as moderate and low.
    CONCLUSIONS: The evidence points out the effectiveness of UV-C technology in reducing manual cleaning failures, enhancing the logarithmic reduction of surface pathogen colonies. However, the safety and success of these devices will depend on several physical and biological factors. A judicious project must precede their use in clinical and medical offices under the supervision of a physicist or other trained professional.
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  • 文章类型: Journal Article
    流感是一种由流感病毒引起的急性呼吸道疾病,经常发生在世界范围内的爆发和流行中。世界卫生组织建议每年为医护人员(HCWs)接种流感疫苗,因为他们中的大多数都参与了对流感相关并发症高风险患者的直接护理。鉴于疾病负担的重要性,我们进行了有针对性的文献综述,以评估HCWs中与流感疫苗接种相关的问题.这篇综述的主要目的是评估医务人员和医疗保健相关流感的发病率。并概述流感疫苗接种对患者和医护人员自身的益处。HCW疫苗接种似乎是减少医护人员向患者传播流感的重要策略,因此,降低患者发病率和死亡率,增加患者安全,并减少HCWs的缺勤率。文献中提到了流感疫苗接种对患者和医护人员自身的益处,但是证据是混合的,而且往往是低质量的。IntJOccupMedEnvironHealth。2022年;35(2):127-39。
    Influenza is an acute respiratory disease caused by the influenza virus which often occurs in outbreaks and epidemics worldwide. The World Health Organization recommends annual vaccination of healthcare workers (HCWs) against influenza, because most of them are involved in the direct care of patients with a high risk of influenza-related complications. Given the significance of the disease burden, a targeted literature review was conducted to assess issues related to influenza vaccination among HCWs. The primary aim of this review was to assess the incidence of influenza among medical personnel and healthcare-associated influenza, and to outline the benefits of influenza vaccination for patients and HCWs themselves. Vaccination of HCWs seems to be an important strategy for reducing the transmission of influenza from healthcare personnel to their patients and, therefore, for reducing patient morbidity and mortality, increasing patient safety, and reducing work absenteeism among HCWs. The benefits of influenza vaccination for their patients and for HCWs themselves are addressed in literature, but the evidence is mixed and often of low-quality. Int J Occup Med Environ Health. 2022;35(2):127-39.
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  • 文章类型: Journal Article
    医疗保健相关感染(HAIs)导致患者发病率和死亡率,仅在美国,每年估计有170万例感染和99,000例死亡,成本为28-340亿美元。对于当前的环境表面消毒实践是否可以减少病原体负荷,随后HAIs,在重症监护环境中。此证据图包括对医疗机构环境表面消毒效果的系统评价。我们筛选了17064份摘要,635全文,共纳入181篇文章,用于数据提取和研究质量评估。我们回顾了十种消毒剂类型,并比较了研究设计方面的消毒剂,结果有机体,和十四个研究质量指标。我们在与研究设计相关的研究中发现了需要改进的重要领域和差距,实施,和分析。实施消毒,消毒结果的决定因素,在大多数研究中没有测量,很少有研究评估真菌或病毒。评估和比较消毒效果受到研究异质性的阻碍;然而,我们对每种消毒类型的结果和结果进行了分类。我们得出的结论是,消毒剂使用指南主要基于实验室数据,而不是对原位消毒效果的系统回顾。对于从业者和研究人员来说,考虑系统级功效而不仅仅是消毒剂的功效至关重要。
    Healthcare-associated infections (HAIs) contribute to patient morbidity and mortality with an estimated 1.7 million infections and 99,000 deaths costing USD $28-34 billion annually in the United States alone. There is little understanding as to if current environmental surface disinfection practices reduce pathogen load, and subsequently HAIs, in critical care settings. This evidence map includes a systematic review on the efficacy of disinfecting environmental surfaces in healthcare facilities. We screened 17,064 abstracts, 635 full texts, and included 181 articles for data extraction and study quality assessment. We reviewed ten disinfectant types and compared disinfectants with respect to study design, outcome organism, and fourteen indictors of study quality. We found important areas for improvement and gaps in the research related to study design, implementation, and analysis. Implementation of disinfection, a determinant of disinfection outcomes, was not measured in most studies and few studies assessed fungi or viruses. Assessing and comparing disinfection efficacy was impeded by study heterogeneity; however, we catalogued the outcomes and results for each disinfection type. We concluded that guidelines for disinfectant use are primarily based on laboratory data rather than a systematic review of in situ disinfection efficacy. It is critically important for practitioners and researchers to consider system-level efficacy and not just the efficacy of the disinfectant.
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  • 文章类型: Journal Article
    卫生环境对于提供优质的患者护理和预防医疗保健获得性感染至关重要。了解成本对服务交付的预算很重要,但是缺乏医疗保健设施(HCF)中环境卫生服务(EHS)的成本证据。我们提出了第一个系统的审查,以评估建立的成本,操作,并在低收入和中等收入国家(LMICs)的HCFs中保持EHS。我们系统地搜索了花费水的研究,卫生,卫生,清洁,废物管理,个人防护装备,矢量控制,洗衣房,和LMICs的照明。我们的搜索产生了36项研究,报告了51项EHS的成本。有3项研究报告了水的成本,3卫生,4卫生,13用于废物管理,16用于清洁,2个人防护装备,10用于洗衣,也没有用于照明或矢量控制。证据质量较低。报告的成本很少代表EHS提供的总成本。单位成本很少报告。ThisreviewidentifiesopportunitiestoimprovecostingresearchthrougheffortstocatorizeanddisaggregateEHScosts,扩大现有未公布数据的传播,改进指标,以监测环境成本所需的EHS需求和质量,并制定框架来定义EHS需求和必要的投入,以指导未来的成本计算。
    A hygienic environment is essential to provide quality patient care and prevent healthcare-acquired infections. Understanding costs is important to budget for service delivery, but costs evidence for environmental health services (EHS) in healthcare facilities (HCFs) is lacking. We present the first systematic review to evaluate the costs of establishing, operating, and maintaining EHS in HCFs in low- and middle-income countries (LMICs). We systematically searched for studies costing water, sanitation, hygiene, cleaning, waste management, personal protective equipment, vector control, laundry, and lighting in LMICs. Our search yielded 36 studies that reported costs for 51 EHS. There were 3 studies that reported costs for water, 3 for sanitation, 4 for hygiene, 13 for waste management, 16 for cleaning, 2 for personal protective equipment, 10 for laundry, and none for lighting or vector control. Quality of evidence was low. Reported costs were rarely representative of the total costs of EHS provision. Unit costs were infrequently reported. This review identifies opportunities to improve costing research through efforts to categorize and disaggregate EHS costs, greater dissemination of existing unpublished data, improvements to indicators to monitor EHS demand and quality necessary to contextualize costs, and development of frameworks to define EHS needs and essential inputs to guide future costing.
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  • 文章类型: Journal Article
    Palliative care for children and young people is a growing global health concern with significant resource implications. Improved understanding of how palliative care provides benefits is necessary as the number of children with life-limiting and life-threatening conditions rises.
    The aim is to investigate beneficial outcomes in palliative care from the perspective of children and families and the contexts and hidden mechanisms through which these outcomes can be achieved.
    This is a systematic realist review following the RAMESES standards. A protocol has been published in PROSPERO (registration no: CRD42018090646).
    An iterative literature search was conducted over 2 years (2015-2017). Empirical research and systematic reviews about the experiences of children and families in relation to palliative care were included.
    Sixty papers were included. Narrative synthesis and realist analysis led to the proposal of context-mechanism-outcome configurations in four conceptual areas: (1) family adaptation, (2) the child\'s situation, (3) relationships with healthcare professionals and (4) access to palliative care services. The presence of two interdependent contexts, the \'expert\' child and family and established relationships with healthcare professionals, triggers mechanisms, including advocacy and affirmation in decision-making, which lead to important outcomes including an ability to place the emphasis of care on lessening suffering. Important child and family outcomes underpin the delivery of palliative care.
    Palliative care is a complex, multifactorial intervention. This review provides in-depth understanding into important contexts in which child and family outcomes can be achieved so that they benefit from palliative care and should inform future service development and practice.
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