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Abstract：
The joint analysis of single-cell transcriptomics, proteomics, lipidomics, metabolomics and spatial metabolomics is continually transforming our understanding of the mechanisms of metabolic reprogramming in tumor cells. Since head and neck tumor is the sixth most common tumor in the world, the study of the metabolic mechanism of its occurrence, development and prognosis is still undeveloped. In the past decade, this field has witnessed tremendous technological revolutions and considerable development that enables major breakthroughs to be made in the study of human tumor metabolism. In this review, a comprehensive comparison of traditional metabolomics and spatial metabolomics has been concluded, and the recent progress and challenges of the application of spatial metabolomics combined multi-omics in the research of metabolic reprogramming in tumors are reviewed. Furthermore, we also highlight the advances of spatial metabolomics in the study of metabolic mechanisms of head and neck tumors, and provide an outlook of its application prospects.
摘要：
单细胞转录组学的联合分析，蛋白质组学，脂质组学，代谢组学和空间代谢组学正在不断改变我们对肿瘤细胞代谢重编程机制的理解。由于头颈部肿瘤是世界上第六大最常见的肿瘤，对其发生的代谢机制的研究，发展和预后仍然不发达。在过去的十年里,该领域经历了巨大的技术革命和长足的发展，使人类肿瘤代谢研究取得了重大突破。在这次审查中,对传统代谢组学和空间代谢组学进行了全面比较，并对空间代谢组学联合多组学在肿瘤代谢重编程研究中的应用进展和面临的挑战进行了综述。此外，我们还强调了空间代谢组学在头颈部肿瘤代谢机制研究中的进展，并对其应用前景进行了展望。
