■多发性硬化症(MS)是一种神经系统疾病,伴有神经元物质脱髓鞘,尤其是白质,有多个发作发生在时间上。它与多种神经和精神后遗症有关。抑郁症和其他情感症状通常与MS有关。先前的研究还表明,精神病症状也可能与MS同时发生。
■准备了住院病房患者的病例报告。随后,基于三个数据库的系统评价和荟萃分析(PRISMA)首选报告项目模型,对文献进行了系统的文献综述.搜索词包括(MS或多发性硬化症)和(精神病或精神分裂症或分裂情感障碍或精神病或幻觉或妄想)。
■文献综述导致在PubMed上最初发现了2711首热门歌曲,在PsycINFO上点击了1276次,在Embase上有5429次命中。一些患者在较早的年龄被诊断为MS,而精神病发作较晚。而有些人最初被诊断为精神病(或精神分裂症),然后是MS。观察到的精神病症状包括迫害妄想,缺乏洞察力,参考的妄想,幻听,宏伟的妄想,和被动。常用的抗精神病药包括利培酮,奥氮平,喹硫平,和阿立哌唑.MS患者中同时发生的精神病的存在强调了对症状进行全面评估的必要性。
■这个案例强调了进行磁共振成像(MRI)大脑的重要性,不仅是对最初发作的精神病,而且对病程相对稳定的患者的任何突然变化也是如此。此外,精神病会影响MS的治疗依从性,使识别和管理它变得更加重要。
UNASSIGNED: Multiple sclerosis (MS) is a neurological disorder with demyelination of neuronal matter, especially of white matter, with multiple episodes occurring temporally. It has been associated with multiple neurological and psychiatric sequelae. Depression and other affective symptoms are commonly associated with MS. Previous research has also suggested that psychotic symptoms may co-occur with MS as well.
UNASSIGNED: A
case report was prepared on the patient admitted to the inpatient unit. Subsequently, a systematic literature review of literature was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) model on three databases. Search terms included (MS OR multiple sclerosis) AND (Psychosis OR schizophrenia OR schizoaffective disorder OR psychotic OR hallucination OR delusion).
UNASSIGNED: The literature review led to an initial discovery of 2711 hits on PubMed, 1276 hits on PsycINFO, and 5429 hits on Embase. Some patients were diagnosed with MS at an earlier age with a later onset of psychosis, while some were initially diagnosed with psychosis (or schizophrenia) first and subsequently with MS. Psychotic symptoms observed included persecutory delusions, lack of insight, delusions of reference, auditory
hallucinations, grandiose delusions, and passivity. The commonly prescribed antipsychotics included risperidone, olanzapine, quetiapine, and aripiprazole. The presence of co-occurring psychosis in MS patients underscores the need for a comprehensive evaluation of symptoms.
UNASSIGNED: This
case highlights the importance of conducting a magnetic resonance imaging (MRI) brain not only for initial onset psychosis but also for any sudden changes in patients who have had a relatively stable course. Moreover, psychosis can affect treatment adherence in MS, making it all the more critical to identify and manage it promptly.