遗传流行病学和基因组学研究产生的信息一直在快速积累,这些知识为公共卫生开辟了新的前景,允许理解基因-环境相互作用。然而,将基于基因组的知识和技术转化为医疗保健实践,尤其是公共卫生,具有挑战性。由于健康影响评估(HIA)被证明是协助考虑健康问题的有效工具,因此是部门决策,本研究旨在通过对遗传流行病学和基因组学研究在HIA中使用的遗传信息进行系统的文献综述,探讨其在转化过程中的作用.PubMed,Scopus,和WebofScience电子数据库进行了搜索,并通过PRISMA指南对研究结果进行了系统审查和报告。综述发现有8项研究符合纳入标准,他们中的大多数人从理论上讨论了在医疗保健实践中使用HIA引入基于基因组的技术,只考虑了两篇文章,简而言之,基因组信息在HIA中通用应用的可能性。研究结果表明,HIA应更广泛地用于将基于基因组的知识转化为公共卫生实践,在HIA过程中应促进基因组信息的使用。
Information generated by genetic epidemiology and genomics studies has been accumulating at fast pace, and this knowledge opens new vistas in public health, allowing for the understanding of gene-environment interactions. However, the translation of genome-based knowledge and technologies to the practice of healthcare, and especially of public health, is challenging. Because health impact assessment (HIA) proved to be an effective tool to assist consideration of health issues is sectoral policymaking, this study aimed at exploring its role in the translational process by a systematic literature
review on the use of genetic information provided by genetic epidemiology and genomics studies in HIA. PubMed, Scopus, and Web of Science electronic databases were searched and the findings systematically reviewed and reported by the PRISMA guidelines. The
review found eight studies that met the inclusion criteria, most of them theoretically discussing the use of HIA for introducing genome-based technologies in healthcare practice, and only two articles considered, in short, the possibility for a generic application of genomic information in HIA. The findings indicate that HIA should be more extensively utilized in the translation of genome-based knowledge to public health practice, and the use of genomic information should be facilitated in the HIA process.