BACKGROUND: In response to the all-time high of female sports participation, there has been increasing scientific discourse and media interest in women\'s sporting injuries in recent years. In gender comparable sports the rate of foot and ankle injury for women is higher than for men. There are intrinsic and extrinsic factors which may explain this difference.
METHODS: A systematic literature search was performed according to the PRISMA guidelines of PubMed, Ovid EMBASE and OVID MEDLINE. Relevant key terms were used to narrow the scope of the search prior to screening. Case reports, review articles, paediatric patients, non foot and ankle injuries and combat sports were excluded. We used dual author, two pass screening to arrive at final included studies.
RESULTS: 2510 articles were screened after duplicate exclusion. 104 were included in this literature review. We identified lack of reporting gender difference in the literature.We identified that females have higher frequency and severity of injury. We provide an overview of our current understanding of ankle ligament complex injuries, stress fractures, ostochondral lesions of the talus and Achilles tendon rupture. We expand on the evidence of two codes of football, soccer and Australian rules, as a \"case study\" of how injury patterns differ between genders in the same sport. We identify gender specific characteristics including severity, types of injury, predisposing risk factors, anatomy, endocrinology and biomechanics associated with injuries. Finally, we examine the effect of level of competition on female injury patterns.
CONCLUSIONS: There is a lack of scientific reporting of gender differences of foot and ankle injuries. Female athletes suffer foot and ankle injuries at higher rates and with greater severity compared to males. This is an under-reported, yet important area of orthopaedics and sports medicine to understand, and hence reduce the injury burden for female athletes.

Previous studies have investigated the association of gender roles with pain outcomes in healthy individuals. However, little is known about this association in those with musculoskeletal (MSK) disorders. Therefore, this mixed-methods systematic review aimed to investigate the association of sociocultural gender roles on pain outcomes in adults with MSK disorders. Literature from Medline, CINAHL, Web of Science, and Embase was reviewed from inception to February 2023. Eligibility criteria included studies of adults with an MSK pain disorder that explored the relationship between gender roles and pain for all primary qualitative and quantitative study designs. Exclusion criteria were gray literature, review articles, case studies, and conference proceedings. Risk of bias was assessed via the Quality Appraisal for Diverse Studies for quantitative studies and the McMaster Quality Appraisal Tool for qualitative studies. Eleven studies were included, 9 qualitative, and 2 quantitative with a total of 540 participants (19.6% women, 80.4% men) with various MSK disorders. The convergent integrated approach was used to synthesize data from the qualitative and quantitative studies resulting in 3 themes and 7 subthemes. Our findings identified differences in the way individuals explained the cause of their pain, were treated for their pain in a social and systemic context, and in describing the effect pain had on their lives based on gender roles. There is a need for pain management to evolve to acknowledge the individual pain experience through exploration of an individual\'s gender identity and roles. PERSPECTIVE: This article demonstrates that gender roles have a multidimensional influence on the pain experience in those with MSK disorders. These findings support the development of gender-sensitive, patient-centered approaches to pain management, acknowledging each individual\'s important roles and identities.

This narrative review examines the interplay among body image perceptions, social media influence, physical measurements, and their impact on psychological well-being, focusing on the roles of cultural and gender differences and the need to understand the research methodologies employed in this field. In the age of digital proliferation, platforms like Instagram and Facebook have reshaped body image concerns, often leading to increased dissatisfaction and psychological distress due to constant exposure to idealized images and a culture of social comparison. Physical attributes such as weight, height, and BMI are scrutinized under societal standards of health and attractiveness, contributing to a spectrum of mental health issues including low self-esteem, depression, and eating disorders. This examination reveals how cultural norms and gender expectations further complicate body image perceptions, affecting individuals differently based on societal and personal ideals. It synthesizes current research and types of methods to illuminate how these factors together influence mental health and self-esteem, advocating for comprehensive interventions and policy measures aimed at mitigating body dissatisfaction and promoting a healthier, more inclusive understanding of body image. By delving into the complexities of body image satisfaction and its psychological implications, this review highlights the necessity of addressing these concerns within public health and social policy frameworks, underscoring the importance of a multifaceted approach to enhance individual and societal well-being.

UNASSIGNED: Discriminatory practices in mental health care undermine the right to health of marginalized service users. Intersectional approaches enable consideration of multiple forms of discrimination that occur simultaneously and remain invisible in single-axis analyses. The authors reviewed intersectionality-informed qualitative literature on discriminatory practices in mental health care to better understand the experiences of marginalized service users and their evaluation and navigation of mental health care.
UNASSIGNED: The authors searched EBSCO, PubMed, MEDLINE, and JSTOR for studies published January 1, 1989-December 14, 2022. Qualitative and mixed-methods studies were eligible if they used an intersectional approach to examine discrimination (experiences, mechanisms, and coping strategies) in mental health care settings from the perspective of service users and providers. A qualitative evidence synthesis with thematic analysis was performed.
UNASSIGNED: Fifteen studies were included in the qualitative evidence synthesis. These studies represented the experiences of 383 service users and 114 providers. Most studies considered the intersections of mental illness with race, sexual and gender diversity, or both and were performed in the United States or Canada. Four themes were identified: the relevance of social identity in mental health care settings, knowledge-related concerns in mental health care, microaggressions in clinical practice, and service users\' responses to discriminatory practices.
UNASSIGNED: Discriminatory practices in mental health care lead to specific barriers to care for multiply marginalized service users. Universities and hospitals may improve care by building competencies in recognizing and preventing discrimination through institutionalized training.

OBJECTIVE: Cigarette smoking prevalence has declined slower among women than men, and smoking-related pulmonary disease (PD) has risen among women. Given these trends, there is a critical need to understand and mitigate PD risk among women who smoke. The purpose of this narrative review and commentary is to highlight important evidence from the literature on smoking and PD among women.
METHODS: This review focuses broadly on examining cigarette smoking and PD among women within six topic areas: (1) demographic characteristics and prevalence of smoking, (2) smoking behavior, (3) lung cancer, (4) obstructive PD, (5) diagnostic and treatment disparities, and (6) gaps in the literature and potential directions for future research and treatment.
RESULTS: Growing evidence indicates that compared to men, women are at increased risk for developing smoking-related PD and poorer PD outcomes. Gender disparities in smoking-related PD may be largely accounted for by genetic differences and sex hormones contributing to PD pathogenesis and presentation, smoking behavior, nicotine dependence, and pathogen/carcinogen clearance. Moreover, gender disparities in smoking-related PD may be exacerbated by important social determinants (e.g., women with less formal education and those from minoritized groups may be at especially high risk for poor PD outcomes due to higher rates of smoking).
CONCLUSIONS: Rising rates of smoking-related PD among women risk widening diagnostic and treatment disparities. Ongoing research is needed to explore potentially complex relationships between sex, gender, and smoking-related PD processes and outcomes, and to improve smoking-cessation and PD treatment for women.

Due to the inevitable differences in physiological and/or genetic factors between genders, the possibility that differences in pharmacokinetics between genders may occur when exposed to the same dose of the same drug is subject to reasonable inference and suspicion. Nevertheless, a significant number of medicines still rely on empirical usage and uniform clinical application without consideration of inter-individual diversity factors. In particular, in the pharmacokinetic diversity of medicines related to central nervous system (CNS) activity, consideration of gender factors and access to comparative analysis are very limited. The purpose of this study was to conduct an integrated analysis and review of differences in pharmacokinetics between genders that have not been specifically reported to date for medicines related to CNS effects, which are a group of drugs with relatively significant concerns about systemic side effects. This study was accessible through extensive data collection and analyzes using a web-based scientific literature search engine of pharmacokinetic results of CNS-related drugs performed on humans, taking gender into account. As a result, significant differences in pharmacokinetics between genders were identified for many drugs related to CNS. And most of the pharmacokinetic differences between genders suggested a higher in vivo exposure in females. This study suggests that consideration of gender factors cannot be ignored and will be an important point of interest in the precision medicine application of CNS-related medicines.

Mental state language (MSL) is an important mechanism through which children learn about their social world and place within it. Previous research has suggested that parents may use MSL differently towards children based on their child\'s gender. However, findings are inconsistent. This scoping review explores the consistency of reported differences in parents\' MSL use as a function of children\'s gender while exploring the methodological variables that may provide insights into these differences. Based on a review of the 27 studies included, 12 found a significant relationship between child gender and parents\' MSL, while the remaining did not. The included studies used a range of methodological approaches to elicit MSL. This scoping review allows researchers and practitioners to reflect upon assumptions regarding the associations between child gender and parents\' MSL. Further, we call for the use of diverse and informed approaches when studying these associations from a developmental perspective in the future.

BACKGROUND: The Covid-19 pandemic had a profound impact on surgical training. In this longitudinal cohort study, we quantify the effects of the pandemic on United Kingdom (UK) surgeons in higher specialty training by analyzing the Annual Review of Competency Progression (ARCP) Outcomes issued to them prior to, and during, the pandemic.
METHODS: Anonymized records were provided from the UK training management system- the Intercollegiate Surgical Curriculum Programme (ISCP)- on the ARCP Outcomes of higher specialty trainees in General Surgery over the period between January 2017 and December 2022. Demographic data including sex and age group on starting higher specialty training were considered, as were working pattern, phase of training during the height of the pandemic (2020 and 2021), and training region. The proportion of nonstandard outcomes, and the use of specific Covid-19 outcomes, were analyzed to assess the impact of these variables on ARCP outcome using univariate and multivariate logistic regression. Prepandemic outcomes in 2017 were used as a comparator.
RESULTS: A total of 7414 ARCP outcomes issued to 1874 General Surgery higher speciality trainees were analysed. The Adjusted Odds Ratio (AOR) for receiving a nonstandard outcome in 2020 (compared to 2017) was 3.07 (95% CI: 2.47-3.81, p < 0.001) not recovering to prepandemic levels by the end of 2022 (AOR 2.11 (95% CI: 1.69-2.64, p < 0.001)). Female sex (AOR 1.27 (95% CI: 1.13-1.43, p < 0.001) and being older on starting higher surgical training (AOR = 1.51 (95% CI: 1.34-1.70, p < 0.001) were both significantly associated with a higher chance of nonstandard outcome. Working pattern was linked to ARCP outcome on univariate analysis, but this relationship disappeared once corrected for other demographic factors (1.05, 95% CI: 0.88-1.24, p = 0.582). Being at a later stage of training during the pandemic was not linked to an increase in AOR of receiving a nonstandard outcome (1.09, 95% CI: 0.97-1.22, p = 0.134), but trainees receiving a nonstandard outcome in this group were more likely to have extra training time advised (15.49%, vs 4.27% in 2021). The highest AOR of receiving a Covid-19 outcome was in the Wessex Deanery at 2.85 (95% CI: 1.83-4.46, p < 0.001), whilst the lowest AOR were seen in Yorkshire and the Humber (0.32, 95% CI: 0.17-0.62, p < 0.001). Removing Covid-19 specific outcomes from the analysis shows a continued rise in the use of nonstandard outcomes in all years except 2020.
CONCLUSIONS: The Covid-19 Pandemic had a significant impact on the trajectory of training in General Surgery in the UK. Training extensions were more likely to be recommended later in training. There was considerable variation in the use of Covid-19 ARCP outcomes across the UK. There is ongoing evidence of differential attainment at ARCP in General Surgery, with female trainees and older graduates having greater chances of nonstandard outcomes. The underlying reasons for these associations need to be explored. Efforts to urgently address deficits in training post Covid-19 with an awareness of the intersectional nature of differential attainment are needed.

UNASSIGNED: The purpose of this review is to examine recent literature (2012-2022) on alcohol treatment access and engagement in women in the U.S. and propose future directions for research and clinical practice.
UNASSIGNED: A targeted literature review resulted in 27 studies encompassing screening and brief intervention (SBIRT), treatment utilization, treatment engagement, and barriers to treatment. Recent literature demonstrates overall low rates of screening and brief interventions and treatment utilization in the population with women less likely to be screened and utilize alcohol treatment. The magnitude of these gender differences varies with race/ethnicity. Extensive barriers to care include provider knowledge, structural barriers, and attitudinal barriers and these vary with service setting, gender, and race/ethnicity.
UNASSIGNED: There is an increasing prevalence of alcohol use and Alcohol Use Disorder (AUD) in women with low rates of screening, brief treatment, treatment, and engagement which have resulted from extensive barriers to care. Possible areas of further inquiry include the impact of race/ethnicity on gender differences, improving provider and system level policies to promote SBIRT and treatment engagement and utilization, further developing digital interventions, and implementation research to investigate factors associated with optimizing effectiveness of gender-responsive and culturally tailored interventions that address the unique needs of women.

Peer victimization during adolescence has a detrimental impact on the mental health of victims throughout their lives. However, it remains unclear whether these effects are gender-specific. The present study conducted a systematic review to examine the effects of peer victimization on depression status, explore potential sources of heterogeneity, and investigate gender differences in these effects. We systematically searched four electronic databases (Web of Science, PubMed, Embase, and CNKI) for relevant articles that published as far as July 2022. We then extracted odds ratios (OR) and 95% confidence intervals (CI) to assess the association between peer victimization during adolescence and depression, and potential gender differences in the relation. Meta-analysis was performed, using fixed effects models and random effects models, to evaluate the association between each exposure and the outcome. A meta-analysis of 27 studies revealed that peer victimization during adolescence was significantly associated with higher risks of depression (OR = 2.79, 95% CI [2.43, 3.21], p < .001). This finding was consistent across subgroup analyses. In particular, the effect of peer victimization during adolescence on depression was found to be more pronounced in studies conducted in Asia (OR = 3.06, 95% CI [2.38, 3.92], p < .001). Furthermore, five studies focused on gender differences demonstrated that peer victimization has a stronger association with the risk of depression in women (OR = 2.84, 95% CI [2.49, 3.26], p < .001). Peer victimization during adolescence is a significant risk factor for depression, with a greater impact on women and individuals residing in Asia. Further prospective studies are needed to investigate the relationship between peer victimization and depression.