背景:脱发可能通过限制患者的社交生活来降低患者的生活质量和自信心。因此,治疗的主要目标是限制或阻止炎症的进展,疤痕,和脱发。脂肪注射对头发再生的有希望的效果,有限的不利影响,消退的炎症可以证明其治疗脱发的有效性和安全性。
目的:本综述旨在评估自体脂肪组织注射在瘢痕和非瘢痕性脱发中的作用。
方法:因此,在科学网上进行了彻底的搜索,Scopus,和PubMed/Medline数据库,以及谷歌学者搜索引擎,对于从开始到9月1日发表的研究,2023年,使用相关关键字。
结果:自体脂肪移植(AFG)是治疗脱发的一种新颖且潜在有效的方法,特别是原发性和继发性瘢痕性脱发。AFG可以是治疗难治性扁平苔藓的有效半侵入性选择,因为它诱导血管生成,支持头发再生。除了瘢痕性脱发,AFG有望治疗非瘢痕性脱发,包括雄激素性脱发和斑秃。脂肪组织(AT)中的脂肪再生细胞(ADRCs)分泌不同的生长因子,进一步支持头发再生。此外,在AT中已知不同的抗炎剂和抗氧化剂,防止毛囊进一步受损。
结论:AFG可以显著控制炎症过程,改善症状和体征,并增加头发密度和直径。
BACKGROUND: Alopecia may decrease patients\' quality of life and self-confidence by limiting their social life. Therefore, the main goal of the treatment is to limit or halt the progression of inflammation, scarring, and hair loss. The promising effect of fat injection on hair regrowth, limited adverse effects, and subsiding inflammation can be proof of its efficacy and safety in treating alopecia.
OBJECTIVE: This
review sought to assess the role of autologous fat tissue injection in scarring and non-scarring alopecia.
METHODS: Accordingly, a thorough search was performed on the Web of Science, Scopus, and PubMed/Medline databases, as well as the Google Scholar search engine, for studies published from inception until September 1st, 2023, using the related keywords.
RESULTS: Autologous fat grafting (AFG) is a novel and potentially effective modality for treating alopecia, particularly primary and secondary cicatricial alopecia. AFG can be an effective semi-invasive option for treating refractory lichen planopilaris because it induces angiogenesis, which supports hair regrowth. In addition to cicatricial alopecia, AFG held promise for treating non-scarring alopecia, including androgenic alopecia and alopecia areata. The adipose-derived regenerative cells (ADRCs) in adipose tissue (AT) secrete different growth factors, further supporting hair regeneration. Moreover, different anti-inflammatory and anti-oxidative agents are known in AT, preventing further damage to hair follicles.
CONCLUSIONS: AFG can significantly control inflammatory processes, improve signs and symptoms, and increase hair density and diameter.