PDF(Pubmed)
Abstract：
A frequent problem following cleft lip repair is insufficient lip volume and unappealing aesthetics. Autologous fat grafting is a method of improving the appearance of post-correction deformity. The aim of this review is to evaluate the effectiveness of autologous fat grafting in improving the aesthetics of cleft lip deformity. The benefits of adipose-derived stem cells (ADSCs), benefits and complications of fat grafting, timing of grafting, and harvest and transplant techniques will be examined. This review process used \"PubMed\" and \"Google Scholar\" as primary databases. Searches were performed using combinations of key terms: \"Fat Graft,\" \"Cleft Lip,\" \"Vermillion,\" \"Autologous Fat Transplantation,\" and \"Adipocyte Derived Stem Cell.\" Reviews of reference lists for additional pertinent data were performed. Autologous fat grafting may be performed during primary repair or as a secondary correction. Statistically significant improvements in appearance were observed in some or all measured variables regardless of repair timing. Both timing options show favorable outcomes; however, there is more evidence in support of grafting as a secondary correction. Some degree of graft reabsorption will occur, lending evidence to the practice of overcorrecting to accommodate losses. Graft retention is stabilized by the 12-month mark. The presence of ADSCs within the graft aids in graft stabilization and retention. Despite a lack of longitudinal data to examine graft retention throughout a patient\'s lifetime, autologous fat grafting appears to be a safe and minimally invasive method of repairing deformity secondary to cleft lip repair supported by follow-up data as far as two years postoperatively with minimal reported complications.
摘要：
唇裂修复后的常见问题是嘴唇体积不足和不吸引人的美学。自体脂肪移植是一种改善矫正后畸形外观的方法。这篇综述的目的是评估自体脂肪移植在改善唇裂畸形美学方面的有效性。脂肪干细胞（ADSC）的好处，脂肪移植的好处和并发症，嫁接的时机，将检查收获和移植技术。此审查过程使用“PubMed”和“GoogleScholar”作为主要数据库。使用关键术语组合进行搜索：“脂肪移植，\"\"唇裂,\"\"朱红色，\"\"自体脂肪移植,“和”脂肪细胞来源的干细胞。\"对其他相关数据的参考列表进行了审查。自体脂肪移植可以在初次修复期间进行或作为二次矫正。无论修复时机如何,在一些或所有测量变量中观察到外观的统计学显著改善。两种时机选择都显示出有利的结果；然而，有更多的证据支持移植作为二次矫正。一定程度的移植物再吸收会发生，为过度纠正以弥补损失的做法提供证据。移植物保留通过12个月标记稳定。移植物内ADSC的存在有助于移植物稳定和保留。尽管缺乏纵向数据来检查患者一生中的移植物保留，自体脂肪移植似乎是一种安全且微创的修复唇裂修复后继发畸形的方法,随访数据支持,随访数据为术后2年,报告的并发症最少.
