未经证实:肺外结核病(EPTB)占所有结核病例的15%-53%。近年来,基于盒的核酸扩增测试(CBNAAT)已成为重要的诊断工具,因为诊断产量更高。我们进行了这项研究,以评估CBNAAT在EPTB中的诊断率。
UNASSIGNED:本研究纳入了104例EPTB患者。样品进行CBNAAT,AFB涂片,结核分枝杆菌培养和组织病理学检查(HPE)。与复合参考标准(CRS)相比,估计每种的产率。
未经证实:最常见的EPTB是淋巴结结核(48.1%)。CBNAAT在30.76%的EPTB病例中呈阳性。骨和关节结核产量最高(35.7%),其次是淋巴结结核(34%)和腹部结核(33.3%)。以CRS为黄金标准,CBNAAT的敏感性为32.3%,AFB培养率为33.3%,HPE为87.2%。
UNASSIGNED:当作为单一诊断工具时,与CBNAAT和AFB培养物相比,HPE在诊断EPTB方面的敏感性最高。单独使用CBNAAT诊断EPTB可能会导致诊断缺失。结合CBNAAT的组合模式,组织病理学和AFB培养是诊断EPTB的最佳方法。
UNASSIGNED: Extrapulmonary Tuberculosis (EPTB) accounts for 15%-53% of all TB cases. In recent years, cartridge-based nucleic acid amplification test (CBNAAT) has emerged as an important diagnostic tool since the diagnostic yield is higher. We conducted this study to evaluate the diagnostic yield of CBNAAT in EPTB.
UNASSIGNED: One hundred and four patients with EPTB were included in the study. Samples were subjected to CBNAAT, AFB smear, culture for Mycobacterium tuberculosis and histopathology examination (HPE). Yield of each was estimated as compared to a composite reference standard (CRS).
UNASSIGNED: The most common EPTB was lymph node TB (48.1%). CBNAAT was positive in 30.76% of EPTB cases. The highest yield was for bone and joint TB (35.7%), followed by lymph node TB (34%) and abdominal TB (33.3%). Taking CRS as the gold standard, sensitivity of CBNAAT was 32.3%, that of AFB culture was 33.3% and that of HPE was 87.2%.
UNASSIGNED: When taken as a single diagnostic tool, HPE had highest sensitivity in diagnosing EPTB when compared to CBNAAT and AFB culture. Use of CBNAAT alone for diagnosis of EPTB may result in missing the diagnosis. A combined modality incorporating CBNAAT, histopathology and AFB culture is the best approach for diagnosis of EPTB.