目的:躯体高警戒描述了一种临床表现,其中人们报告更多,更强烈,身体的感觉比平常。大多数对躯体过度警惕的解释都暗示了信息处理的改变,但缺乏强有力的经验数据。注意力和工作记忆对信息处理至关重要,我们旨在评估有和没有躯体过度警惕的人在注意力/工作记忆任务期间的大脑活动。
方法:数据来自173名躯体高度警觉者和173名年龄相匹配的对照者,性别,用手,和多年的教育进行了分析。事件相关潜力(ERP)数据,从执行听觉奇点任务期间获得的连续脑电图记录中提取,和两行(TIAR)任务,N1,P2,N2和P3用于分析.用双尾独立t检验评估P3振幅和N2振幅和潜伏期的组间差异。使用混合评估N1和P2振幅和潜伏期的组间差异,重复测量的方差分析(方差分析)与组和组×站点因素。线性回归分析研究了焦虑和抑郁之间的关系以及任何有意义的结果。
结果:具有躯体高警惕性的人表现出较小的P3振幅-听觉Oddball任务:t(285)=2.32,95%置信区间,CI[3.48,4.47],p=.026,d=0.27;两列(TIAR)任务:t(334)=2.23,95%CI[2.20;3.95],p=.021,d=0.24-比病例匹配的对照。N2振幅在躯体高警惕性-TIAR任务人群中也较小:t(318)=2.58,95%CI[0.33,2.47],p=.010,d=0.29-比病例匹配的对照。抑郁或焦虑与任何结果都没有显着相关。
结论:躯体过度警觉的人对注意力/工作记忆任务表现出与事件相关的潜在反应,这与信息处理的改变相一致。
OBJECTIVE: Somatic hypervigilance describes a clinical presentation in which people report more, and more intense, bodily sensations than is usual. Most explanations of somatic hypervigilance implicate altered information processing, but strong empirical data are lacking. Attention and working memory are critical for information processing, and we aimed to evaluate brain activity during attention/working memory tasks in people with and without somatic hypervigilance.
METHODS: Data from 173 people with somatic hypervigilance and 173 controls matched for age, gender, handedness, and years of education were analyzed. Event-related potential (ERP) data, extracted from the continuous electroencephalograph recordings obtained during performance of the Auditory Oddball task, and the Two In A Row (TIAR) task, for N1, P2, N2, and P3, were used in the analysis. Between-group differences for P3 amplitude and N2 amplitude and latency were assessed with two-tailed independent t tests. Between-group differences for N1 and P2 amplitude and latency were assessed using mixed, repeated measures analyses of variance (ANOVAs) with group and Group × Site factors. Linear regression analysis investigated the relationship between anxiety and depression and any outcomes of significance.
RESULTS: People with somatic hypervigilance showed smaller P3 amplitudes-Auditory Oddball task: t(285) = 2.32, 95% confidence interval, CI [3.48, 4.47], p = .026, d = 0.27; Two-In-A-Row (TIAR) task: t(334) = 2.23, 95% CI [2.20; 3.95], p = .021, d = 0.24-than
case-matched controls. N2 amplitude was also smaller in people with somatic hypervigilance-TIAR task: t(318) = 2.58, 95% CI [0.33, 2.47], p = .010, d = 0.29-than in
case-matched controls. Neither depression nor anxiety was significantly associated with any outcome.
CONCLUSIONS: People with somatic hypervigilance demonstrated an event-related potential response to attention/working memory tasks that is consistent with altered information processing.