当囊泡生产过程被优化时,脂囊泡可以提供皮肤药物吸收的成本有效的增强。设计理想的囊泡是一个重要的挑战，因为它们的属性和特征是相关的，因为一个的变化会影响另一个。这里,我们回顾了主要组成部分，常用的制备和表征方法，以及导致用于透皮药物递送目的的高效囊泡的关键特性。我们站在大小，变形程度和载药量，作为最重要的囊泡特征决定了药物的进一步透皮吸收。对这项技术的兴趣正在增加，正如关于该主题的出版物的指数增长所证明的那样。尽管长期保存和可扩展性问题限制了脂质囊泡产品的商业化，冷冻干燥和现代升级方法克服了这些困难，从而预测这些技术在市场和临床实践中的更高应用。
Lipid vesicles can provide a cost-effective enhancement of skin drug absorption when vesicle production process is optimised. It is an important challenge to design the ideal vesicle, since their properties and features are related, as changes in one affect the others. Here, we review the main components, preparation and characterization methods commonly used, and the key properties that lead to highly efficient vesicles for transdermal drug delivery purposes. We stand by size, deformability degree and drug loading, as the most important vesicle features that determine the further transdermal drug absorption. The interest in this technology is increasing, as demonstrated by the exponential growth of publications on the topic. Although long-term preservation and scalability issues have limited the commercialization of lipid vesicle products, freeze-drying and modern escalation methods overcome these difficulties, thus predicting a higher use of these technologies in the market and clinical practice.
