■本研究的主要目的是调查患有精神病或抑郁症的子宫内膜异位症患者的特征。次要目的是在这种情况下研究Dienogest的耐受性。
■这项观察性病例对照研究包括2015-2021年在我们诊所就诊的子宫内膜异位症患者的数据。我们根据结构化调查从患者图表和电话访谈中收集信息。包括手术证实的子宫内膜异位症患者。
■344例患者符合纳入标准:n=255例无精神障碍,n=119任何精神疾病和n=70抑郁症。抑郁症患者(EM-D,p=.018;p=.035)或精神疾病(EM-P,p=.020;p=.048)更常遭受性交困难和精神错乱。EM-P患者更经常发生原发性痛经,疼痛评分更高(p=.045)。rASRM分期或病灶定位没有差异。EM-D和EM-P患者停止饮食治疗更经常与情绪恶化有关(p=.001,p=.002)。
■EM-D或EM-P的疼痛症状患病率较高。这不能归因于rASRM分期或子宫内膜异位症病变位置的差异。强烈的原发性痛经可能容易发展为基于慢性疼痛的心理症状。因此,早期诊断和治疗是相关的。妇科医生应该意识到孕妇对情绪的潜在影响。
患有子宫内膜异位症和精神疾病的女性尤其患有更多的性交困难和性交困难,独立于rASRM阶段,子宫内膜异位症病变的浸润深度和定位。Dienogest对情绪有影响,尤其是在已经易感的患者中。试用登记:试用登记号:NCT04816357。https://clinicaltrials.gov/ct2/show/NCT04816357注册日期:22.03.2021,第一科目注册日期:25.03.2021。
UNASSIGNED: Primary aim of this study was to investigate endometriosis characteristics of patients with psychiatric conditions or depression. The secondary aim was to study tolerability of dienogest in this context.
UNASSIGNED: This observational
case-control study included endometriosis data from patients visiting our clinic from 2015-2021. We collected information from patient charts and in phone interviews based on a structured survey. Patients with surgical confirmed endometriosis were included.
UNASSIGNED: 344 patients fulfilled the inclusion criteria: n = 255 no psychiatric disorder, n = 119 any psychiatric disorder and n = 70 depression. Patients with depression (EM-D, p=.018; p=.035) or psychiatric condition (EM-P, p=.020; p=.048) suffered more often from dyspareunia and dyschezia. EM-P patients had more often primary
dysmenorrhoea with higher pain scores (p=.045). rASRM stage or localisation of lesions did not differ. EM-D and EM-P patients discontinued dienogest treatment more often related to worsening of mood (p= .001, p=.002).
UNASSIGNED: EM-D or EM-P had a higher prevalence of pain symptoms. This could not be attributed to differences in rASRM stage or location of endometriosis lesions. Strong primary
dysmenorrhoea might predispose to develop chronic pain-based psychological symptoms. Therefore, early diagnosis and treatment are relevant. Gynaecologist should be aware of the potential impact of dienogest on mood.
Women with endometriosis and psychiatric disorders especially have more dyschezia and dyspareunia, independent from rASRM stage, depth of infiltration and localisation of endometriosis lesions. Dienogest has an impact on mood especially in already prone patients.Trial registration: trial registration number: NCT04816357. https://clinicaltrials.gov/ct2/show/NCT04816357Date of registration: 22.03.2021, date of enrolment of the first subject: 25.03.2021.