■特应性皮炎(AD),牛皮癣,与红皮病相关的药物反应经常因感染而复杂化。然而,血流感染(BSI)受到的研究关注较少。
■本研究旨在探讨红皮病患者与BSI相关的临床特征和危险因素。
■对141例红皮病病例进行回顾性分析。11例患者被确定为患有BSI。回顾并比较了BSI和非BSI组的临床记录。
■在7.80%(11/141)的红皮病病例中诊断出BSI,在AD中分解为7.14%,2.00%的牛皮癣,药物反应占17.14%。值得注意的是,所有阳性皮肤培养物(7/7)均显示细菌分离株与血液培养物一致。单因素logistic回归分析显示与BSI有几个显著关联,包括温度(≤36.0或≥38.5°C;比值比(OR)=28.06;p<0.001),冷却(OR=22.10;p<0.001),肾脏疾病(OR=14.64;p<0.001),药物反应的病因(OR=4.18;p=0.03),白蛋白(ALB)(OR=0.86;p<0.01),C反应蛋白(CRP)(OR=1.01;p=0.02),白细胞介素6(IL-6)(OR=1.02;p=0.02),和降钙素原(PCT)(OR=1.07;p=0.03)。受试者工作特征(ROC)曲线显示与ALB显著相关(p<0.001;曲线下面积(AUC)=0.80),PCT(p=0.009;AUC=0.74),和CRP(p=0.02;AUC=0.71)。
■提高对BSI风险的认识在红皮病管理中至关重要。有特定危险因素的患者,如体温异常(≤36.0或≥38.5℃),令人不寒而栗的感觉,肾病,有药物反应史,CRP升高(≥32mg/L),PCT升高(≥1.00ng/ml),和低白蛋白(≤31.0g/L),需要密切监测BSI的发展。
UNASSIGNED: Atopic dermatitis (AD), psoriasis, and drug reactions associated with erythroderma are frequently complicated by infections. However, bloodstream infection (BSI) have received less research attention.
UNASSIGNED: This
study aimed to investigate the clinical characteristics and risk factors associated with BSI in patients with erythroderma.
UNASSIGNED: A retrospective analysis was conducted on 141 erythroderma cases. Eleven cases were identified as having BSI. Clinical records of both BSI and non-BSI groups were reviewed and compared.
UNASSIGNED: BSI was diagnosed in 7.80% (11/141) of erythroderma cases, with a breakdown of 7.14% in AD, 2.00% in psoriasis, and 17.14% in drug reactions. Notably, all positive skin cultures (7/7) showed bacterial isolates concordant with blood cultures. Univariate logistic regression analysis revealed several significant associations with BSI, including temperature (≤36.0 or ≥38.5 °C; odds ratio (OR) = 28.06; p < 0.001), chilling (OR = 22.10; p < 0.001), kidney disease (OR = 14.64; p < 0.001), etiology of drug reactions (OR = 4.18; p = 0.03), albumin (ALB) (OR = 0.86; p < 0.01), C-reaction protein (CRP) (OR = 1.01; p = 0.02), interleukin 6 (IL-6) (OR = 1.02; p = 0.02), and procalcitonin (PCT) (OR = 1.07; p = 0.03). Receiver operating characteristic (ROC) curves demonstrated significant associations with ALB (p < 0.001; the area under curve (AUC) = 0.80), PCT (p = 0.009; AUC = 0.74), and CRP (p = 0.02; AUC = 0.71).
UNASSIGNED: Increased awareness of BSI risk is essential in erythroderma management. Patients with specific risk factors, such as abnormal body temperature (≤36.0 or ≥38.5 °C), chilling sensations, kidney disease, a history of drug reactions, elevated CRP (≥32 mg/L), elevated PCT (≥1.00 ng/ml), and low albumin (≤31.0 g/L), require close monitoring for BSI development.