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Abstract：
UNASSIGNED: Atopic dermatitis (AD), psoriasis, and drug reactions associated with erythroderma are frequently complicated by infections. However, bloodstream infection (BSI) have received less research attention.
UNASSIGNED: This study aimed to investigate the clinical characteristics and risk factors associated with BSI in patients with erythroderma.
UNASSIGNED: A retrospective analysis was conducted on 141 erythroderma cases. Eleven cases were identified as having BSI. Clinical records of both BSI and non-BSI groups were reviewed and compared.
UNASSIGNED: BSI was diagnosed in 7.80% (11/141) of erythroderma cases, with a breakdown of 7.14% in AD, 2.00% in psoriasis, and 17.14% in drug reactions. Notably, all positive skin cultures (7/7) showed bacterial isolates concordant with blood cultures. Univariate logistic regression analysis revealed several significant associations with BSI, including temperature (≤36.0 or ≥38.5 °C; odds ratio (OR) = 28.06; p < 0.001), chilling (OR = 22.10; p < 0.001), kidney disease (OR = 14.64; p < 0.001), etiology of drug reactions (OR = 4.18; p = 0.03), albumin (ALB) (OR = 0.86; p < 0.01), C-reaction protein (CRP) (OR = 1.01; p = 0.02), interleukin 6 (IL-6) (OR = 1.02; p = 0.02), and procalcitonin (PCT) (OR = 1.07; p = 0.03). Receiver operating characteristic (ROC) curves demonstrated significant associations with ALB (p < 0.001; the area under curve (AUC) = 0.80), PCT (p = 0.009; AUC = 0.74), and CRP (p = 0.02; AUC = 0.71).
UNASSIGNED: Increased awareness of BSI risk is essential in erythroderma management. Patients with specific risk factors, such as abnormal body temperature (≤36.0 or ≥38.5 °C), chilling sensations, kidney disease, a history of drug reactions, elevated CRP (≥32 mg/L), elevated PCT (≥1.00 ng/ml), and low albumin (≤31.0 g/L), require close monitoring for BSI development.
UNASSIGNED: This study aimed to investigate the clinical characteristics and risk factors associated with BSI in patients with erythroderma.
UNASSIGNED: A retrospective analysis was conducted on 141 erythroderma cases. Eleven cases were identified as having BSI. Clinical records of both BSI and non-BSI groups were reviewed and compared.
UNASSIGNED: BSI was diagnosed in 7.80% (11/141) of erythroderma cases, with a breakdown of 7.14% in AD, 2.00% in psoriasis, and 17.14% in drug reactions. Notably, all positive skin cultures (7/7) showed bacterial isolates concordant with blood cultures. Univariate logistic regression analysis revealed several significant associations with BSI, including temperature (≤36.0 or ≥38.5 °C; odds ratio (OR) = 28.06; p < 0.001), chilling (OR = 22.10; p < 0.001), kidney disease (OR = 14.64; p < 0.001), etiology of drug reactions (OR = 4.18; p = 0.03), albumin (ALB) (OR = 0.86; p < 0.01), C-reaction protein (CRP) (OR = 1.01; p = 0.02), interleukin 6 (IL-6) (OR = 1.02; p = 0.02), and procalcitonin (PCT) (OR = 1.07; p = 0.03). Receiver operating characteristic (ROC) curves demonstrated significant associations with ALB (p < 0.001; the area under curve (AUC) = 0.80), PCT (p = 0.009; AUC = 0.74), and CRP (p = 0.02; AUC = 0.71).
UNASSIGNED: Increased awareness of BSI risk is essential in erythroderma management. Patients with specific risk factors, such as abnormal body temperature (≤36.0 or ≥38.5 °C), chilling sensations, kidney disease, a history of drug reactions, elevated CRP (≥32 mg/L), elevated PCT (≥1.00 ng/ml), and low albumin (≤31.0 g/L), require close monitoring for BSI development.
摘要：
■特应性皮炎（AD），牛皮癣,与红皮病相关的药物反应经常因感染而复杂化。然而,血流感染（BSI）受到的研究关注较少。
■本研究旨在探讨红皮病患者与BSI相关的临床特征和危险因素。
■对141例红皮病病例进行回顾性分析。11例患者被确定为患有BSI。回顾并比较了BSI和非BSI组的临床记录。
■在7.80％（11/141）的红皮病病例中诊断出BSI，在AD中分解为7.14%，2.00%的牛皮癣，药物反应占17.14%。值得注意的是,所有阳性皮肤培养物（7/7）均显示细菌分离株与血液培养物一致。单因素logistic回归分析显示与BSI有几个显著关联，包括温度（≤36.0或≥38.5°C；比值比（OR）=28.06；p<0.001），冷却(OR=22.10；p<0.001)，肾脏疾病（OR=14.64；p<0.001），药物反应的病因（OR=4.18；p=0.03），白蛋白（ALB）（OR=0.86；p<0.01），C反应蛋白（CRP）（OR=1.01；p=0.02），白细胞介素6（IL-6）（OR=1.02；p=0.02），和降钙素原（PCT）（OR=1.07；p=0.03）。受试者工作特征(ROC)曲线显示与ALB显著相关(p<0.001;曲线下面积(AUC)=0.80),PCT（p=0.009；AUC=0.74），和CRP(p=0.02;AUC=0.71)。
■提高对BSI风险的认识在红皮病管理中至关重要。有特定危险因素的患者，如体温异常（≤36.0或≥38.5℃），令人不寒而栗的感觉，肾病,有药物反应史,CRP升高（≥32mg/L），PCT升高（≥1.00ng/ml），和低白蛋白（≤31.0g/L），需要密切监测BSI的发展。
■本研究旨在探讨红皮病患者与BSI相关的临床特征和危险因素。
■对141例红皮病病例进行回顾性分析。11例患者被确定为患有BSI。回顾并比较了BSI和非BSI组的临床记录。
■在7.80％（11/141）的红皮病病例中诊断出BSI，在AD中分解为7.14%，2.00%的牛皮癣，药物反应占17.14%。值得注意的是,所有阳性皮肤培养物（7/7）均显示细菌分离株与血液培养物一致。单因素logistic回归分析显示与BSI有几个显著关联，包括温度（≤36.0或≥38.5°C；比值比（OR）=28.06；p<0.001），冷却(OR=22.10；p<0.001)，肾脏疾病（OR=14.64；p<0.001），药物反应的病因（OR=4.18；p=0.03），白蛋白（ALB）（OR=0.86；p<0.01），C反应蛋白（CRP）（OR=1.01；p=0.02），白细胞介素6（IL-6）（OR=1.02；p=0.02），和降钙素原（PCT）（OR=1.07；p=0.03）。受试者工作特征(ROC)曲线显示与ALB显著相关(p<0.001;曲线下面积(AUC)=0.80),PCT（p=0.009；AUC=0.74），和CRP(p=0.02;AUC=0.71)。
■提高对BSI风险的认识在红皮病管理中至关重要。有特定危险因素的患者，如体温异常（≤36.0或≥38.5℃），令人不寒而栗的感觉，肾病,有药物反应史,CRP升高（≥32mg/L），PCT升高（≥1.00ng/ml），和低白蛋白（≤31.0g/L），需要密切监测BSI的发展。
