色素性扁平苔藓(LPP)是一种以持续和无症状的棕黑色至蓝色或紫灰色色素沉着为特征的疾病,主要在面部和阳光照射的区域,通常在深色皮肤的个体中。已经报道了LPP的几种临床变体。然而,LPP的鱼鳞状类型尚未报道。我们介绍了一名19岁的男性患者,他有7年的无症状灰色斑疹病史;脸上有细小鳞屑的斑块,树干,和上肢;和浅灰色斑块,下肢上有厚的“鱼鳞状”鳞片。LPP的诊断已通过黄斑和鱼鳞状斑块的组织病理学发现得到证实。簇分化(CD)68染色突出了灰色斑点和鱼鳞状斑块中相同密度的色素巨噬细胞。LPP的病因未知。转录因子异常可能在扁平苔藓病变的角质化增加中起作用。可以认为,角质化分布改变的机制可能发生在该患者的鱼鳞状病变上。特此建议将术语“鱼鳞状扁平苔藓”添加到LPP的临床变体中。
Lichen planus pigmentosus (LPP) is a condition characterized by persistent and asymptomatic brownish-black-to-blue or purple-gray pigmentation, predominantly in the face and sun-exposed areas, commonly in dark-skinned individuals. Several clinical variants of LPP have been reported. However, the ichthyosiform type of LPP has not been reported. We present a 19-year-old male patient who presented with a 7-year history of asymptomatic grayish macules; patches with fine scales on the face, trunk, and upper extremities; and grayish plaques with thick \"ichthyosiform\" scales on the lower extremities. The diagnosis of LPP was proven by histopathological findings on both the macular and ichthyosiform plaques. Cluster differentiation (CD) 68 stain highlights the same density of pigment-laden macrophages in both the gray macule and the ichthyosiform plaque. The cause of LPP is unknown. Transcription factor anomalies may play a role in increased keratinization of lichen planus lesions. It can be assumed that the mechanism of the altered distribution of keratinization may occur on the ichthyosiform lesions in this patient. The terminology \"ichthyosiform lichen planus pigmentosus\" is hereby proposed to be added to the clinical variants of LPP.