他汀类药物是治疗高脂血症的一线药物。除了降低血脂,它还能降低死亡率和心血管风险.他汀类药物通过许多不同的机制在维持口腔稳态中起主要作用。它包括通过骨形态发生蛋白(BMP)-2途径分化和矿化组织发育增加的牙本质和牙髓的再生。它通过导致成骨分化间充质干细胞显示有效的骨健康,通过促进伤口愈合中的上皮化过程,抗炎,抗氧化剂,抗菌,抗病毒,和杀真菌特性。我们掌握的最好的信息,很少有全面的研究调查他汀类药物对牙齿和口腔健康各个方面的影响。因此,本综述的主要目的是研究他汀类药物对口腔健康应用的影响.根据我们广泛审查的结果,他汀类药物对口腔健康的几个方面有显著和有希望的效果,包括牙髓细胞,慢性牙周炎,牙槽骨丢失,正畸牙齿移动,等等。然而,结论是,局部甚至全身给药辛伐他汀应被视为一种创新,容易接近,和安全的治疗剂,对增强口腔健康有重大影响。
Statins are the first line of treatment for hyperlipidaemia. Along with lowering lipids, it also lowers mortality and cardiovascular risk. Statins play a major role in maintaining the homeostasis of the oral cavity via a number of different mechanisms. It includes regeneration of dentin and pulp by differentiation and increased development of mineralized tissue via the bone morphogenetic proteins (BMP)-2 Pathway. It shows effective bone health by leading to osteogenic differentiation mesenchymal stem cells, by facilitating epithelization process in wound healing, anti-inflammatory, antioxidant, antimicrobial, antiviral, and fungicidal properties. To the finest of the information we have, there have been very few comprehensive studies that have investigated the effects of statin drugs on various aspects of dental and oral health. As a result, the main objective of this
review was to examine the effect of statins on oral health applications. According to the findings of our extensive
review, statins have noteworthy and promising effects on several aspects of oral health, including dental pulp cells, chronic periodontitis, alveolar bone loss, orthodontic tooth movement, and so on. Nevertheless, it is concluded that local or even systemic administration of simvastatin should be regarded as an innovative, easily accessible, and safe therapeutic agent that has a significant impact on enhancing the oral health.