PDF(Pubmed)
Abstract：
Dental pulp stem cells (DPSCs) are a type of mesenchymal stem cells that can differentiate into odontoblast-like cells and protect the pulp. The differentiation of DPSCs can be influenced by biomaterials or growth factors that activate different signaling pathways in vitro or in vivo. In this review, we summarized six major pathways involved in the odontogenic differentiation of DPSCs, Wnt signaling pathways, Smad signaling pathways, MAPK signaling pathways, NF-kB signaling pathways, PI3K/AKT/mTOR signaling pathways, and Notch signaling pathways. Various factors can influence the odontogenic differentiation of DPSCs through one or more signaling pathways. By understanding the interactions between these signaling pathways, we can expand our knowledge of the mechanisms underlying the regeneration of the pulp-dentin complex.
摘要：
牙髓干细胞（DPSC）是一种间充质干细胞，可以分化为成牙本质细胞样细胞并保护牙髓。DPSC的分化可以受到体外或体内激活不同信号通路的生物材料或生长因子的影响。在这次审查中,我们总结了参与DPSCs牙源性分化的6个主要通路,Wnt信号通路,Smad信号通路,MAPK信号通路,NF-kB信号通路,PI3K/AKT/mTOR信号通路,和Notch信号通路。多种因素可以通过一个或多个信号通路影响DPSC的牙源性分化。通过了解这些信号通路之间的相互作用，我们可以扩大对牙髓牙本质复合体再生机制的认识。
