藏红花(Crocussativus)是一种天然化合物,其成分如藏红花,番红花素,和Safranal具有许多药理特性,如抗氧化剂,抗炎,抗肿瘤,抗基因毒性,抗抑郁药,保肝,心脏保护,和神经保护。核因子-红系2相关因子2(Nrf2)信号通路在对抗炎症、氧化应激,和致癌作用。在Nrf2信号通路的调控中,Kelch样ECH相关蛋白1(keap1)是研究最多的途径。在这次审查中,我们收集了各种研究,描述了藏红花及其成分的药理作用及其相关作用机制,特别是Nrf2信号通路。在这次审查中,我们使用搜索引擎或电子数据库,包括Scopus,WebofScience,和Pubmed,没有时间限制。搜索关键词包含藏红花,\"番红花\"番红花素,crocin,Safranal,picrocroccin,“核因子红系2相关因子2”,Nrf2藏红花及其成分可以通过各种机制,特别是Nrf2/HO-1/Keap1信号通路在肝脏等不同组织中具有保护作用,心,大脑,胰腺,肺,接头,结肠,等。这篇综述中讨论的绝大多数研究表明,藏红花及其成分可以诱导Nrf2信号通路,从而导致其抗氧化和治疗作用。
Saffron (Crocus sativus) is a natural compound and its constituents such as crocin,
crocetin, and safranal have many pharmacological properties such as anti-oxidant, anti-inflammatory, antitumor, antigenotoxic, anti-depressant, hepatoprotective, cardioprotective, and neuroprotective. The nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway plays an important role against inflammation, oxidative stress, and carcinogenesis. In the regulation of the Nrf2 signaling pathway, kelch-like ECH-associated protein 1 (keap1) is the most studied pathway. In this
review, we gathered various studies and describe the pharmacological effects of saffron and its constituents with their related mechanisms of action, particularly the Nrf2 signaling pathway. In this
review, we used search engines or electronic databases including Scopus, Web of Science, and Pubmed, without time limitation. The search keywords contained saffron, \"Crocus sativus\",
crocetin, crocin, safranal, picrocrocin, \"nuclear factor erythroid 2-related factor 2\", and Nrf2. Saffron and its constituents could have protective properties through various mechanisms particularly the Nrf2/HO-1/Keap1 signaling pathway in different tissues such as the liver, heart, brain, pancreas, lung, joints, colon, etc. The vast majority of studies discussed in this
review indicate that saffron and its constituents could induce the Nrf2 signaling pathway leading to its anti-oxidant and therapeutic effects.