Abstract：
The effect of Crocus sativus on several disorders has been discussed or even confirmed, but the efficacy of this herb on the female reproductive system has not been well presented. In this regard, this systematic review comprehensively discussed the efficacy of C. sativus and its main phytochemical compounds on the female reproductive system and its disorders for the first time. In this systematic review, scientific databases, including PubMed, Web of Sciences, Google Scholar, Scopus, and Scientific Information Database, were explored profoundly. In vivo, in vitro, and human studies published until the end of July 2023, which had investigated the pharmacological properties of C. sativus, crocin, crocetin, safranal, or picrocrocin on the female reproductive system, were selected. A total of 50 studies conducted on the effect of C. sativus on the female reproductive system were acquired. These studies confirmed the efficacy of C. sativus or its main phytochemical ingredients in several aspects of the female reproductive system, including regulation of sex hormones, folliculogenesis, ovulation, and protection of the ovary and uterus against several oxidative stress. Several retrieved studies indicated that this herb also can alleviate the symptoms of patients suffering from dysmenorrhea, premenstrual syndrome, menopause, polycystic ovary disease (PCOD), and sexual dysfunction. Furthermore, it is a promising candidate for future studies or even trials regarding ovarian and cervical cancers. This review concluded that C. sativus can improve the symptoms of several female reproductive system disorders, which is particularly due to the presence of phytochemical ingredients, such as crocin, crocetin, and safranal.
摘要：
番红花对几种疾病的影响已经被讨论甚至证实，但是这种草药对女性生殖系统的功效还没有很好的呈现。在这方面,该系统综述首次全面讨论了C.sativus及其主要植物化学成分对女性生殖系统及其疾病的功效。在这次系统审查中，科学数据库,包括PubMed,WebofSciences,谷歌学者，Scopus,和科学信息数据库，进行了深刻的探索。在体内,在体外，和直到2023年7月底发表的人类研究，调查了C.sativus的药理特性，crocin,番红花素,Safranal,或者是女性生殖系统上的picrocrocin,被选中。获得了关于C.sativus对女性生殖系统影响的总共50项研究。这些研究证实了C.sativus或其主要植物化学成分在雌性生殖系统几个方面的功效，包括调节性激素,卵泡发生，排卵,保护卵巢和子宫免受多种氧化应激。检索到的一些研究表明，这种草药还可以减轻痛经患者的症状，经前综合症,更年期,多囊卵巢疾病（PCOD），和性功能障碍。此外，它是未来有关卵巢癌和宫颈癌的研究甚至试验的有希望的候选者.本综述的结论是C.sativus可以改善几种女性生殖系统疾病的症状，特别是由于植物化学成分的存在，比如crocin,番红花素,和Safranal.
