颅面区域包含皮肤,骨头,软骨,颞下颌关节,牙齿,牙周组织,粘膜,唾液腺,肌肉,神经,和血管。应用组织工程治疗有助于替换创伤或癌症后丢失的组织。尽管最近取得了进展,标准化和验证最合适的动物模型以有效地将临床前数据转化为临床情况仍然至关重要.因此,本文综述了各种动物模型在颅面组织工程和再生中的应用。这项研究基于PubMed,Scopus,和谷歌学者的数据可到2023年1月。这项研究仅包括描述动物模型在颅面组织工程中的应用的英文出版物(体内和综述研究)。研究选择是基于评估标题,摘要,和全文。初始研究的总数为6454。在筛选过程之后,最终清单上仍有295篇文章。许多体内研究表明,小型和大型动物模型可以通过评估新治疗干预措施的有效性和安全性来使临床疾病受益。设备,以及具有与人类类似疾病/缺陷的动物的生物材料。不同的物种解剖,生理,在开发创新时必须考虑生物学特征,可重复,和判别实验模型,为特定的组织缺损选择合适的动物模型。因此,了解人类医学和兽医学之间的相似之处可以使这两个领域受益。
The craniofacial region contains skin, bones, cartilage, the temporomandibular joint (TMJ), teeth, periodontal tissues, mucosa, salivary glands, muscles, nerves, and blood vessels. Applying tissue engineering therapeutically helps replace lost tissues after trauma or cancer. Despite recent advances, it remains essential to standardize and validate the most appropriate animal models to effectively translate preclinical data to clinical situations. Therefore, this
review focused on applying various animal models in craniofacial tissue engineering and regeneration. This research was based on PubMed, Scopus, and Google Scholar data available until January 2023. This study included only English-language publications describing animal models\' application in craniofacial tissue engineering (in vivo and
review studies). Study selection was based on evaluating titles, abstracts, and full texts. The total number of initial studies was 6454. Following the screening process, 295 articles remained on the final list. Numerous in vivo studies have shown that small and large animal models can benefit clinical conditions by assessing the efficacy and safety of new therapeutic interventions, devices, and biomaterials in animals with similar diseases/defects to humans. Different species\' anatomical, physiologic, and biological features must be considered in developing innovative, reproducible, and discriminative experimental models to select an appropriate animal model for a specific tissue defect. As a result, understanding the parallels between human and veterinary medicine can benefit both fields.