目的:评估角膜变性过程中上皮厚度的变化,角膜色素沉着,以及通过光谱域光学相干断层扫描(SD-OCT)在短头犬中观察到的其他特征。
■该研究使用了49只短头犬的55只眼,这些犬接受了包含OCT的眼科检查。被检查的眼睛被分类为角膜变性,角膜色素沉着,和正常组根据角膜病变。对于每一只眼睛,中央角膜的角膜上皮厚度(CET)和角膜缘4个象限的最大角膜缘上皮厚度(maxLET)(上,劣等,鼻部,和时间)从OCT图像中测量。OCT图像的其他异常发现,包括不规则的上皮,上皮下高反射率,结膜松弛症,也被记录下来。
结果:角膜变性组鼻部和颞部的上颌骨明显比正常组薄(p<.001)。在角膜变性组的中央角膜OCT图像中,70.6%的上皮不规则,82.4%的上皮下高反射率,两者均显著高于正常组(p<.001)。在比较分析中,鼻部,temporal,与正常组相比,角膜色素沉着组的下maxLET明显变薄(分别为p<.001,p<.001和p=.01)。
结论:在角膜变性和角膜色素沉着的犬中观察到角膜缘上皮的形态变化。LET减少可能与它们的发病机理有关,并且作为角膜疾病的额外参数将是有价值的。
OBJECTIVE: To evaluate alterations in epithelial thickness during corneal degeneration, corneal pigmentation, and additional features observed through spectral-domain optical coherence tomography (SD-OCT) in brachycephalic dogs.
UNASSIGNED: The study used 55 eyes from 49 brachycephalic dogs that underwent OCT-containing ophthalmic examinations. The examined eyes were classified into corneal degeneration, corneal pigmentation, and normal groups according to corneal lesions. For each eye, corneal epithelial thickness (CET) in the central cornea and maximum limbal epithelial thickness (maxLET) in 4 quadrants of limbus (superior, inferior, nasal, and temporal) were measured from OCT images. Additional abnormal findings on OCT images, including irregular epithelium, subepithelial hyperreflectivity, and conjunctivochalasis, were also recorded.
RESULTS: The corneal degeneration group had significantly thinner nasal and temporal maxLETs than that of the normal group (p < .001). In the central corneal OCT image of the corneal degeneration group, an irregular epithelium was observed in 70.6% and subepithelial hyperreflectivity in 82.4%, both of which were significantly higher than the normal group (p < .001). In a comparative analysis, the nasal, temporal, and inferior maxLETs were significantly thinner in the corneal pigmentation group than those in the normal group (p < .001, p < .001, and p = .01, respectively).
CONCLUSIONS: Morphological changes in the limbal epithelium were observed in dogs with corneal degeneration and corneal pigmentation. LET reduction could be associated with their pathogenesis and would be valuable as an additional parameter for corneal diseases.