PDF(Pubmed)
Abstract：
BACKGROUND: To compare the epithelial thickness map of ptotic eyes of blepharoptosis patients with contralateral non- ptotic eyes.
METHODS: Unilateral blepharoptosis patients were enrolled consecutively. Patients were underwent full ophthalmologic examination and their demographic data such as age and gender and specific ptosis findings e.g. the cause and duration, MRD-1, and levator palpebralis superioris function were registered. Anterior segment imaging for epithelial thickness measurements was done using the Avanti RTVue-XR platform. The corneal epithelial thickness maps of ptotic and non-ptotic eyes were compared.
RESULTS: 44 patients with unilateral blepharoptosis were included in the study. 27 (61.4%) of them were female and 17 (38.6%) cases were male. The mean of the patients\' ages was 24.40 ± 15.16 years. Ptotic eyes had significantly thinner superior (p = 0.000), superior-temporal (p = 0.000) and superior-nasal (p = 0.005) sectors of the cornea and slightly thicker corneal epithelium (CE) in the inferior-nasal sector. The correlation of difference of superior-inferior CE was evaluated with different parameters including patient\'s age (p = 0.457), type of blepharoptosis (p = 0.786), duration of blepharoptosis (p = 0.477) and MRD1 (p = 0.248), but no correlation was found.
CONCLUSIONS: This study revealed that lid position in blepharoptosis may have effects on the corneal epithelial thickness map. Because of the lower position of upper eyelid, a thinning effect on superior corneal sectors may happen.
METHODS: Unilateral blepharoptosis patients were enrolled consecutively. Patients were underwent full ophthalmologic examination and their demographic data such as age and gender and specific ptosis findings e.g. the cause and duration, MRD-1, and levator palpebralis superioris function were registered. Anterior segment imaging for epithelial thickness measurements was done using the Avanti RTVue-XR platform. The corneal epithelial thickness maps of ptotic and non-ptotic eyes were compared.
RESULTS: 44 patients with unilateral blepharoptosis were included in the study. 27 (61.4%) of them were female and 17 (38.6%) cases were male. The mean of the patients\' ages was 24.40 ± 15.16 years. Ptotic eyes had significantly thinner superior (p = 0.000), superior-temporal (p = 0.000) and superior-nasal (p = 0.005) sectors of the cornea and slightly thicker corneal epithelium (CE) in the inferior-nasal sector. The correlation of difference of superior-inferior CE was evaluated with different parameters including patient\'s age (p = 0.457), type of blepharoptosis (p = 0.786), duration of blepharoptosis (p = 0.477) and MRD1 (p = 0.248), but no correlation was found.
CONCLUSIONS: This study revealed that lid position in blepharoptosis may have effects on the corneal epithelial thickness map. Because of the lower position of upper eyelid, a thinning effect on superior corneal sectors may happen.
摘要：
背景：比较上睑下垂患者与对侧非上眼睑眼的上皮厚度图。
方法：连续纳入单侧上睑下垂患者。患者接受了全面的眼科检查，以及他们的人口统计学数据，如年龄和性别，以及具体的上下垂发现，如原因和持续时间，记录了MRD-1和上提肌功能。使用AvantiRTVue-XR平台进行上皮厚度测量的前段成像。比较了眼睑和非眼睑眼的角膜上皮厚度图。
结果：44例单侧上睑下垂患者被纳入研究。其中女性27例（61.4%），男性17例（38.6%）。患者的平均年龄为24.40±15.16岁。上侧眼明显变薄（p=0.000），角膜的颞上（p=0.000）和鼻上（p=0.005）部分以及鼻下部分的角膜上皮（CE）稍厚。不同参数包括患者的年龄（p=0.457）评估了CE的上下差异的相关性，眼睑类型（p=0.786），上睑下垂的持续时间（p=0.477）和MRD1（p=0.248），但没有发现相关性。
结论：这项研究表明，眼睑下垂的眼睑位置可能会影响角膜上皮厚度图。因为上眼睑位置较低，可能会对上角膜部分产生变薄的影响。
方法：连续纳入单侧上睑下垂患者。患者接受了全面的眼科检查，以及他们的人口统计学数据，如年龄和性别，以及具体的上下垂发现，如原因和持续时间，记录了MRD-1和上提肌功能。使用AvantiRTVue-XR平台进行上皮厚度测量的前段成像。比较了眼睑和非眼睑眼的角膜上皮厚度图。
结果：44例单侧上睑下垂患者被纳入研究。其中女性27例（61.4%），男性17例（38.6%）。患者的平均年龄为24.40±15.16岁。上侧眼明显变薄（p=0.000），角膜的颞上（p=0.000）和鼻上（p=0.005）部分以及鼻下部分的角膜上皮（CE）稍厚。不同参数包括患者的年龄（p=0.457）评估了CE的上下差异的相关性，眼睑类型（p=0.786），上睑下垂的持续时间（p=0.477）和MRD1（p=0.248），但没有发现相关性。
结论：这项研究表明，眼睑下垂的眼睑位置可能会影响角膜上皮厚度图。因为上眼睑位置较低，可能会对上角膜部分产生变薄的影响。
