本研究旨在使用网络荟萃分析评估不同血液衍生物对伤口愈合的临床效果。PubMed,Embase,OVID,WebofScience,搜索SCOPUS和CochraneCentral,以获得有关血液衍生物对伤口愈合的研究,直到2023年10月。采用R4.2.0和Stata15.0软件进行数据分析。纳入了包括5164名患者的44项研究。网络荟萃分析结果显示,愈合区由高到低依次为GF+ORCCB,ORCCB,GF,PRF,Unnas糊状敷料,APG,PRP进样,PRP,PRP+凝血酶凝胶,PPP,HPL,CT。愈合时间从低到高是PRP+凝血酶凝胶,GF,PRP,PC+K,PC,APG,PRF,CT,磺胺嘧啶银软膏。从高到低治愈的患者数量为APG,PRP进样,PRP,Aurix,PRF,Leucopatch,HPL,抗菌软膏敷料,CT,60μg/cm2repifermin,120μg/cm2repifermin,AFG,PPP。镇痛效果从高到低的顺序是AFG,Aminogam凝胶,PRF,PRP,氧化油,APG,GF,CT。伤口感染病例数从低到高的顺序是APG,20μg/cm2repifermin,60μg/cm2repifermin,PRP,LeucoPatch,CT,PPP,防腐软膏敷料。愈合面积:GF+ORCCB效果最好;愈合时间:PRP+凝血酶凝胶时间最短。治愈的患者人数和伤口感染的减少:APG效果最好。镇痛效果:AFG效果最好。需要更多样本量大的研究来证实上述发现。
This study aims to evaluate the clinical effects of different blood derivatives on wound healing using network meta-analysis. PubMed, Embase, OVID, Web of Science, SCOPUS and Cochrane Central were searched to obtain studies about blood derivatives on wound healing until October 2023. R 4.2.0 and Stata 15.0 softwares were used for data analysis. Forty-four studies comprising 5164 patients were included. The results of network meta-analysis showed that the healing area from high to low was GF + ORCCB, ORCCB, GF, PRF, Unnas paste dressing, APG, PRP injection, PRP, PRP + thrombin gel, PPP, HPL, CT. The healing time from low to high was PRP + thrombin gel, GF, PRP, PC + K, PC, APG, PRF, CT, Silver sulfadiazine ointment. The number of patients cured from high to low was APG, PRP injection, PRP, Aurix, PRF, Leucopatch, HPL, Antimicrobial Ointment Dressing, CT, 60 μg/cm2 repifermin, 120 μg/cm2 repifermin, AFG, PPP. The order of analgesic effect from high to low was AFG, Aminogam gel, PRF, PRP, Oxidised oil, APG, GF, CT. The order of the number of wound infection cases from low to high is APG, 20 μg/cm2 repifermin, 60 μg/cm2 repifermin, PRP, LeucoPatch, CT, PPP, Antiseptic ointment dressing. Healing area: GF + ORCCB had the best effect; Healing time: PRP + thrombin gel took the shortest time. The number of cured patients and the reduction of wound infection: APG has the best effect. Analgesic effect: AFG has the best effect. More studies with large sample sizes are needed to confirm the above findings.