特权1,2,3-三唑支架由于其在药物发现等各个领域的广泛应用而引起了研究人员的注意(例如,羧基酰胺三唑),有机合成(点击反应模板),聚合物材料(例如,三唑聚体),超分子受体(例如,三唑烷),荧光材料(例如,金属有机框架),和农业部门(例如,杀菌剂)。目前市场上也有各种1,2,3-三唑说服模块,它们具有多种资产,例如活性药物和农业用途。得益于高度一致和最坚定的综合方法,也就是说,铜(I)催化的1,3-偶极环加成(CuAAC)对各种叠氮化物和乙炔衍生物的点击反应,高度官能化的1,2,3-三唑以标量产率制备用于药物发现。鉴于1,2,3-三唑化学的重要性,本综述特别关注与天然药效团连接的结构多样的1,2,3-三唑的合成及其生物学重要性。此外,双重/多重药效团同化的1,2,3-三唑已经列出了有趣的生物活性,这些活性可能作为未来的药物线索是有价值的。此外,这项全面的审查可以作为开发新的多样化支架的模板,这些支架将确保为现有的无数疾病和病症提供新的治疗方法。
The privileged 1,2,3-triazole scaffold is drawing researcher\'s attention due to its widespread applications in diverse fields such as drug discovery (e.g., carboxyamidotriazole), organic synthesis (click-reaction template), polymeric materials (e.g., triazolamer), supramolecular receptors (e.g., triazolophane), fluorescent materials (e.g., metal-organic frameworks), and agricultural sectors (e.g., fungicides). Various 1,2,3-triazole persuasion modules are also currently available in the market that have multiple assets such as active pharmaceuticals and agricultural purposes. Owed to the highly consistent and firmest synthesis approach, that is, click reaction of various azides and acetylene derivatives by copper (I)-catalyzed 1,3-dipolar cycloaddition (CuAAC), highly functionalized 1,2,3-triazoles are prepared in scalar yields for drug discovery. Given the importance of 1,2,3-triazole chemistry, the present
review focuses specifically on the synthesis of structurally diverse 1,2,3-triazoles linked to natural pharmacophores and their biological importance. Furthermore, the dual/multi-pharmacophores assimilated 1,2,3-triazoles have listed interesting biological activities that could be valuable as future drug leads. In addition, this comprehensive
review can serve as a template for the development of new diverse scaffolds that will ensure for new therapeutic approaches for the existing myriad diseases and disorders.