背景:未分化多形性肉瘤(UPS)约占所有软组织肉瘤(STS)病例的15%,5年生存预后约为60%。由于其复杂性,肿瘤通常通过临床和病理排除来识别。UPS常见于四肢,所以在躯干和胸壁发现它们是罕见的。本系统评价的主要目标是:(I)确定病变的患者特征;(II)汇编手术后的患者结果;(III)确定最佳治疗方式;(IV)表征报告的病变组织学;(V)评估当前的手术切除建议;(VI)对病变进行分类及其与放射的关联。
方法:PRISMA框架用于识别病例报告和记录,提供关于胸壁UPS的信息。病例报告和文章进行了相关性筛选,全文可访问性,如果它们包含术语(“未分化多形性肉瘤”,“乳房”,“胸壁”,或“树干”)在其标题或摘要中。PubMed数据库是主数据库,从2003年1月1日至2023年5月21日,检索标准为"(未分化多形性肉瘤)和((乳腺)或(躯干)或(胸部)或(胸壁)".鉴于这些是病例报告,偏倚风险和异质性由于其困难而未评估。病例报告的信息被汇编成表,并进行卡方检验。但没有完成荟萃分析.
结果:在433项研究中,选择了24份病例报告和22份记录来告知胸壁的UPS。24例病例报告产生了32例病例,提供了有关患者预后的信息,肿瘤特征,和治疗。没有进行荟萃分析,但文献被总结为关于治疗这种疾病的信息。病例报告汇编成表,提供患者年龄信息,性别,肿瘤位置,治疗方式,边距距离,和其他因素。
结论:涉及胸部的UPS的治疗极其复杂。与典型的UPS不同,它在女性中比在男性中更常见,这项研究的结果证实了这一点。该研究还注意到接受治疗的患者与未接受其他疗法治疗的患者之间的复发或转移没有差异。
BACKGROUND: Undifferentiated pleomorphic sarcoma (UPS) accounts for approximately 15% of all soft-tissue sarcoma (STS) cases and have a 5-year survival prognosis of around 60%. Due to its complexity, tumors are often identified by clinical and pathological exclusion. UPS is commonly found in the extremities, so finding them in the trunk and chest wall is rare. The primary objectives of this systematic
review are: (I) identifying patient characteristics with lesion; (II) compiling patient outcomes following surgery; (III) identifying best therapy modalities; (IV) characterizing reported lesion histology; (V) assessing current surgical recommendations for resection; (VI) classifying lesions and their association with radiation.
METHODS: The PRISMA framework was utilized to identify case reports and records providing information on UPS in the chest wall. Case reports and articles were screened for relevance, full-text accessibility, and if they contained the terms (\"undifferentiated pleomorphic sarcoma\", \"breast\", \"chest wall\", or \"trunk\") in their title or abstract. The PubMed database was the primary database, and the search criteria was \"(undifferentiated pleomorphic sarcoma) AND ((breast) OR (trunk) OR (chest) OR (chest wall))\" from 01/01/2003 to 05/21/2023. Given that these were case reports, bias risk and heterogeneity was not assessed due to its difficulty. Information from case reports were compiled into a table and a Chi-squared test was performed, but no meta-analysis was completed.
RESULTS: Of 433 studies, 24 case reports and 22 records were selected to inform on UPS in the chest wall. The 24 case reports yielded 32 cases providing information on patient outcomes, tumor characteristics, and treatment. A meta-analysis was not performed, but literature was summarized to inform on treating the condition. Case reports were compiled into a table providing information on patient age, gender, tumor location, treatment modalities, margin distance, and other factors.
CONCLUSIONS: Treatment of UPS involving the chest is extremely complex. Unlike typical UPS, it is more often found in women than in men, which is corroborated by the results of this study. This study also notes no difference in recurrence or metastasis between patient who were treated and those who were not treated with other therapies.