小脑与社交能力和自闭症有关。鉴于小脑通过小脑-丘脑-皮质环连接到皮质,参与社交互动的小脑和皮质区域之间的连通性,也就是说,右颞顶叶交界处(rTPJ)已在自闭症患者中进行了研究,他们遭受社交能力的典型缺陷。然而,现有的分类小样本研究,由于自闭症的固有异质性,病例对照比较产生了不一致的结果,这表明调查临床维度与小脑-rTPJ功能连接的关系可能更相关。因此,我们的目的是研究小脑和rTPJ之间的功能连接,在诊断样本中,从维度角度关注其与社交能力的关联。我们分析了结构磁共振成像(MRI)和功能磁共振成像(fMRI)扫描在自然电影观看过程中从一个大的诊断数据集,健康大脑网络(HBN)并检查了小脑-rTPJ功能连接与社会反应性量表(SRS)测量的社交能力之间的关联。我们进行了单变量种子-体素分析,多元典型相关分析(CCA),和预测支持向量回归(SVR)。我们在结构分析中包括1404名受试者(年龄:10.516±3.034,范围:5.822-21.820,506名女性)和414名受试者(年龄:11.260±3.318岁,范围:6.020-21.820,161名女性)。我们的CCA模型揭示了小脑-rTPJ功能连接之间的显著关联,全面智商(FSIQ)和SRS评分。然而,这种效应主要由SVR和单变量种子-体素分析所提示的FSIQ驱动.我们还证明了rTPJ的特异性以及结构解剖学在此关联中的影响。我们的结果表明,小脑-rTPJ连通性之间存在复杂的关系,社会绩效和智商。这种关系特定于小脑-rTPJ连通性,很大程度上与这两个区域的结构解剖有关。实践要点:我们分析了儿科诊断样本中的小脑-右颞顶交界(rTPJ)连接。我们发现小脑和rTPJ连通性之间存在复杂的关系,社会绩效和智商。小脑和rTPJ功能连接与这两个区域的结构解剖有关。
The
cerebellum has been involved in social abilities and autism. Given that the
cerebellum is connected to the cortex via the cerebello-thalamo-cortical loop, the connectivity between the cerebellum and cortical regions involved in social interactions, that is, the right temporo-parietal junction (rTPJ) has been studied in individuals with autism, who suffer from prototypical deficits in social abilities. However, existing studies with small samples of categorical, case-control comparisons have yielded inconsistent results due to the inherent heterogeneity of autism, suggesting that investigating how clinical dimensions are related to cerebellar-rTPJ functional connectivity might be more relevant. Therefore, our objective was to
study the functional connectivity between the
cerebellum and rTPJ, focusing on its association with social abilities from a dimensional perspective in a transdiagnostic sample. We analyzed structural magnetic resonance imaging (MRI) and functional MRI (fMRI) scans obtained during naturalistic films watching from a large transdiagnostic dataset, the Healthy Brain Network (HBN), and examined the association between cerebellum-rTPJ functional connectivity and social abilities measured with the social responsiveness scale (SRS). We conducted univariate seed-to-voxel analysis, multivariate canonical correlation analysis (CCA), and predictive support vector regression (SVR). We included 1404 subjects in the structural analysis (age: 10.516 ± 3.034, range: 5.822-21.820, 506 females) and 414 subjects in the functional analysis (age: 11.260 ± 3.318 years, range: 6.020-21.820, 161 females). Our CCA model revealed a significant association between cerebellum-rTPJ functional connectivity, full-scale IQ (FSIQ) and SRS scores. However, this effect was primarily driven by FSIQ as suggested by SVR and univariate seed-to-voxel analysis. We also demonstrated the specificity of the rTPJ and the influence of structural anatomy in this association. Our results suggest that there is a complex relationship between
cerebellum-rTPJ connectivity, social performance and IQ. This relationship is specific to the cerebellum-rTPJ connectivity, and is largely related to structural anatomy in these two regions. PRACTITIONER POINTS: We analyzed cerebellum-right temporoparietal junction (rTPJ) connectivity in a pediatric transdiagnostic sample. We found a complex relationship between cerebellum and rTPJ connectivity, social performance and IQ.
Cerebellum and rTPJ functional connectivity is related to structural anatomy in these two regions.