我们报告了一名38岁的白种人,该男子参加了一项旨在使用先进的显微镜技术研究红细胞(RBC)的物理性质的研究。包括原子力显微镜(AFM)。在他第一次参加这项研究的时候,空腹血糖(FPG)值正常,BMI为24.1,没有其他糖尿病症状,包括疲劳,高甘油三酯,低HDL胆固醇,并改变炎症和红细胞指数。受试者报告无糖尿病家族史,肥胖,和心血管疾病。尽管他看起来很健康,他的红细胞的生物力学被改变了,显示增加的刚度和粘度值。机械测量后超过1年,受试者因高血糖和糖化血红蛋白(HbA1c)水平升高而被纳入PoliclinicoGemelli医院糖尿病业务科,并被诊断为1型糖尿病(T1DM).这里,我们展示这些数据,我们讨论了以下假设:RBC机械特性可能对T1DM糖尿病前期发生的变化敏感。
We report the
case of a 38 year-old Caucasian man enrolled in a study aimed at investigating the physical properties of red blood cells (RBCs) using advanced microscopy techniques, including Atomic Force Microscopy (AFM). At the time of his first enrolment in the study, he had normal Fasting Plasma Glucose (FPG) values, a BMI of 24.1, and no other symptoms of diabetes, including fatigue, high triglycerides, low HDL cholesterol, and altered inflammatory and corpuscular RBC indices. The subject reported no family history of diabetes, obesity, and cardiovascular diseases. Despite his apparently healthy conditions, the biomechanics of his RBCs was altered, showing increased values of stiffness and viscosity. More than 1 year after the mechanical measurements, the subject was admitted to the Operational Unit of Diabetology of the Policlinico Gemelli Hospital with high blood glucose and glycosylated hemoglobin (HbA1c) levels and diagnosed with type 1 diabetes (T1DM). Here, we show these data, and we discuss the hypothesis that RBC mechanical properties could be sensitive to changes occurring during the pre-diabetic phase of T1DM.