常规疗法通常用于治疗炎症性皮肤病,但是不良影响,如红斑,干燥度,皮肤变薄,和对治疗的抵抗力,可能导致患者依从性差。因此,患者可能会寻求草药植物产品,包括精油(EO)的补充治疗。本范围审查旨在对用于治疗炎症性皮肤病的EO进行广泛的概述,即,寻常痤疮,皮炎和湿疹,牛皮癣,还有酒渣鼻,在临床环境中。质量,功效,以及各种EO的安全性,以及他们准备的方式,被审查,和潜力,以及局限性,讨论了用于治疗炎性皮肤病的EOs。29项符合条件的研究(案例研究,不受控制的临床研究,和随机临床研究)从科学电子数据库(PubMed,Embase,Scopus,和Cochrane图书馆)。作为最初的结果,茶树(互叶白千层)油成为研究最多的EO。茶树油凝胶治疗痤疮的临床研究显示,与常规治疗相比,不良反应少。不受控制的研究表明ajwain(Trachyspermumammi)油的潜在功效,桉树油,和雪松(Cedruslibani)油在治疗痤疮,但是需要进一步的研究才能得出确凿的证据。安慰剂对照研究揭示了卡努卡(Kunzeaericoides)油和乳香(Boswelliaspp。)用于治疗牛皮癣和湿疹的油。EO产品的质量验证不一致,一些研究缺乏分析和透明度。一些研究的质量限制包括样本量小,持续时间短,没有对照组.本次审查强调了延长,精心设计的临床研究,以进一步评估EO治疗炎症性皮肤疾病的疗效和安全性,并进一步阐明所涉及的作用机制。
Conventional therapy is commonly used for the treatment of inflammatory skin conditions, but undesirable effects, such as erythema, dryness, skin thinning, and resistance to treatment, may cause poor patient compliance. Therefore, patients may seek complementary treatment with herbal plant products including essential oils (EOs). This scoping
review aims to generate a broad overview of the EOs used to treat inflammatory skin conditions, namely, acne vulgaris, dermatitis and eczema, psoriasis, and rosacea, in a clinical setting. The quality, efficacy, and safety of various EOs, as well as the way in which they are prepared, are reviewed, and the potential, as well as the limitations, of EOs for the treatment of inflammatory skin conditions are discussed. Twenty-nine eligible studies (case studies, uncontrolled clinical studies, and randomized clinical studies) on the applications of EOs for inflammatory skin conditions were retrieved from scientific electronic databases (PubMed, Embase, Scopus, and the Cochrane Library). As an initial result, tea tree (Melaleuca alternifolia) oil emerged as the most studied EO. The clinical studies with tea tree oil gel for acne treatment showed an efficacy with fewer adverse reactions compared to conventional treatments. The uncontrolled studies indicated the potential efficacy of ajwain (Trachyspermum ammi) oil, eucalyptus (Eucalyptus globulus) oil, and cedarwood (Cedrus libani) oil in the treatment of acne, but further research is required to reach conclusive evidence. The placebo-controlled studies revealed the positive effects of kānuka (Kunzea ericoides) oil and frankincense (Boswellia spp.) oil in the treatment of psoriasis and eczema. The quality verification of the EO products was inconsistent, with some studies lacking analyses and transparency. The quality limitations of some studies included a small sample size, a short duration, and the absence of a control group. This present
review underscores the need for extended, well-designed clinical studies to further assess the efficacy and safety of EOs for treating inflammatory skin conditions with products of assured quality and to further elucidate the mechanisms of action involved.