背景:颈动脉内膜中层厚度(IMT)是儿童动脉粥样硬化的亚临床放射学标志物。它与成人发作的血管疾病相关。
目的:从文献中观察到的结果确定IMT的正常儿科值。
方法:我们的系统评价是根据PRISMA指南进行的。我们审查了从成立到2023年2月的2298篇英语文章。纳入标准包括根据美国心脏协会评估基于B型和射频(RF)的IMT测量的研究。欧洲小儿心脏病学协会,曼海姆共识,和美国超声心动图协会的建议。对汇总数据进行荟萃分析,以获得IMT的置信区间(CI),使用95%的置信水平。
结果:我们对6184名儿童进行了88项基于B模式的IMT测量研究,对766名儿童进行了6项基于射频回波跟踪的研究。儿科人群的平均IMT为0.43mm,95%[CI]0,42至0.44,使用B模式技术,和0.41毫米,使用射频技术,95%[CI]0.36至0.45。在IMT和年龄之间没有检测到显著的关系(p值=0.83)。最后,性别对IMT无显著影响(B型p值=0.82,RFp值=0.62).
结论:根据本文献综述中选择的研究,我们无法得出结论,男孩和女孩的平均IMT之间存在显著差异.年龄和IMT之间没有关系。IMT是特定于技术的,和正常值应根据公认共识的建议进行解释,以抵消当前文献中的异质性。
结论:技术和儿童特异性内膜介质厚度测量有助于临床医生和科学家评估儿童动脉粥样硬化的风险。
结论:•在没有危险因素的儿童中,内膜中层厚度(IMT)与年龄无关。•根据目前的文献,健康男孩和女孩之间的IMT没有差异。•存在异质性,即使研究遵守官方共识。
BACKGROUND: Carotid artery intima-media thickness (IMT) is a sub-clinical radiologic marker of atherosclerosis in children. It is associated with adult-onset vascular disease.
OBJECTIVE: To determine normal pediatric values of IMT from results observed in the literature.
METHODS: Our systematic review was conducted according to PRISMA
guidelines. We reviewed 2298 English articles from inception to February 2023. Inclusion criteria included studies evaluating B-mode and radiofrequency (RF)-based IMT measurements based on the American Heart Association, the Association for European Pediatric Cardiology, the Mannheim
Consensus, and the American Society of Echocardiography recommendations. A meta-analysis of aggregate data was conducted to obtain the confidence interval (CI) for IMT, using a 95% confidence level.
RESULTS: We obtained 88 B-mode-based IMT measurement studies with 6184 children and six radiofrequency echo-tracking-based studies with 766 children. Mean IMT in the pediatric population was 0.43 mm, 95% [CI] 0,42 to 0.44, using the B-mode technique, and 0.41 mm, 95% [CI] 0.36 to 0.45 using the radiofrequency technique. No significant relationship was detected between IMT and age (p value = 0.83). Finally, no significant effect of sex on IMT was found (p value = 0.82 for B-mode and p value = 0.62 for RF).
CONCLUSIONS: Based on the studies selected in this literature review, we were unable to conclude that there was a significant difference between the average IMT of boys and girls. No relationship was demonstrated between age and IMT. IMT is technique-specific, and normal values should be interpreted according to recommendations of recognized
consensus to counteract the current heterogeneity in literature.
CONCLUSIONS: Technique and children-specific Intima media thickness measurements help clinicians and scientists to assess the risk of atherosclerosis in children.
CONCLUSIONS: • Intima-media thickness (IMT) does not correlate with age in children without risk factors. • According to current literature, there is no difference in IMT between healthy boys and girls. • There is heterogeneity, even with studies abiding by the official
consensus.