狼疮性肾炎(LN),疾病活动,并观察到血清β2-微球蛋白(b2MG)。本研究探讨了血清b2MG与肾脏受累的相关性,损伤分数,系统性红斑狼疮(SLE)患者的疾病活动性。来自AinShams大学医院的100名SLE患者被纳入并分为两组。第一组有40例b2MG阴性患者,而II组有60例患者b2MG水平阳性。病史,临床检查,并根据SLE疾病活动指数(SLEDAI-2K)评估疾病活动,并记录所有患者的损伤评分。实验室检查,如血清b2MG,全血细胞计数,血尿素氮(BUN),血清肌酐,肾小球滤过率(GFR),尿液分析,24h尿蛋白排泄,抗核抗体(ANA),抗dsDNA抗体,和血清补体(C3,C4)。BUN,24h尿蛋白,血清肌酐,尿沉渣活性,SLEDAI得分,与I组相比,II组的损伤评分均升高(p<0.001)。血清b2MG与24h尿蛋白呈正相关,BUN,血清肌酐,疾病活动,和损伤评分(p<0.001),虽然它与GFR呈负相关,C3和C4(p<0.001)。血清b2MG已被证明是SLE患者LN的预测因子(敏感性92.45%,特异性74.47%),也是疾病活动性和损伤指数的预测因子(灵敏度96.67%,特异性85%)(灵敏度92.45%,特异性74.47%),分别。血清b2MG水平可作为LN的有价值的预测因子,临床疾病活动,和伤害得分。
A strong correlation between lupus nephritis (LN), disease activity, and serum beta 2-microglobulin (b2MG) was observed. The current
study examines the correlation between serum b2MG and renal involvement, damage score, and disease activity in systemic lupus erythematosus (SLE) patients. One hundred SLE patients from Ain Shams University Hospital were enrolled and categorized into two groups. Group I had 40 patients with negative b2MG, while Group II had 60 patients with positive b2MG levels. Medical history, clinical examination, and assessing disease activity based on SLE disease activity index (SLEDAI-2 K), and damage score were recorded for all patients. Laboratory examinations, such as serum b2MG, complete blood count, blood urea nitrogen (BUN), serum creatinine, glomerular filtration rate (GFR), urine analysis, 24 h urinary protein excretion, Antinuclear antibodies (ANA), anti-dsDNA antibody, and serum complement (C3, C4). BUN, 24 h urinary protein, serum creatinine, active urinary sediment, SLEDAI score, and damage score were all elevated in group II compared to group I (p < 0.001). There is a positive correlation between serum b2MG and 24 h urinary protein, BUN, serum creatinine, disease activity, and damage score (p < 0.001), while it was negatively correlated with GFR, C3, and C4 (p < 0.001). Serum b2MG has proven to be a predictor of LN in SLE patients (Sensitivity 92.45%, Specificity 74.47%), also being a predictor of the activity of the disease as well as damage index (Sensitivity 96.67%, Specificity 85%) (Sensitivity 92.45%, Specificity 74.47%), respectively. Serum b2MG level can be used as a valuable predictor for LN, clinical disease activity, and damage score.