Abstract：
BACKGROUND: Sjögren\'s syndrome (SS) is a chronic autoimmune disease characterized by lymphocytic infiltrates in the exocrine glands. Carpal tunnel syndrome (CTS) is suggested to be more frequent among SS patients than in the general population. The aim of this study was to seek associations between the CTS and the laboratory and clinical findings of SS patients.
METHODS: Fifty patients diagnosed with primary SS (pSS) were examined. Clinical evaluation by a rheumatologist and electrophysiological studies were conducted. Data on laboratory tests results was collected. Control group consisted of 50 sex and age-matched individuals with osteoarthritis (OA).
RESULTS: Out of 50 patients in the study group 27 (54%) were diagnosed with CTS. The prevalence of CTS among 50 individuals in the control group was 8%. Among pSS patients with CTS the joint involvement was not more common than in those from the non-CTS group [15 vs. 13 (p = 0.945)]. There was an expected difference in sleep disorders [18 vs. 9 (p = 0.012)] and paresthesia [23 vs. 13 (p = 0.024)]. The major finding was a significant difference in elevated beta2-microglobulin (B2MG) [23 vs. 13 (p = 0.024)]. Other studied factors, suggested in the literature as significant in the pSS-related neuropathy, were not statistically different between the groups.
CONCLUSIONS: Our study confirms that CTS is more prevalent among pSS patients than in the general population and suggests that a new approach is required towards the pathogenesis of this phenomenon. We hypothesize that CTS is more associated with an overall disease activity than joint involvement as such.
METHODS: Fifty patients diagnosed with primary SS (pSS) were examined. Clinical evaluation by a rheumatologist and electrophysiological studies were conducted. Data on laboratory tests results was collected. Control group consisted of 50 sex and age-matched individuals with osteoarthritis (OA).
RESULTS: Out of 50 patients in the study group 27 (54%) were diagnosed with CTS. The prevalence of CTS among 50 individuals in the control group was 8%. Among pSS patients with CTS the joint involvement was not more common than in those from the non-CTS group [15 vs. 13 (p = 0.945)]. There was an expected difference in sleep disorders [18 vs. 9 (p = 0.012)] and paresthesia [23 vs. 13 (p = 0.024)]. The major finding was a significant difference in elevated beta2-microglobulin (B2MG) [23 vs. 13 (p = 0.024)]. Other studied factors, suggested in the literature as significant in the pSS-related neuropathy, were not statistically different between the groups.
CONCLUSIONS: Our study confirms that CTS is more prevalent among pSS patients than in the general population and suggests that a new approach is required towards the pathogenesis of this phenomenon. We hypothesize that CTS is more associated with an overall disease activity than joint involvement as such.
摘要：
背景：干燥综合征（SS）是一种慢性自身免疫性疾病，其特征是外分泌腺中的淋巴细胞浸润。建议SS患者的腕管综合征（CTS）比普通人群更常见。这项研究的目的是寻求CTS与SS患者的实验室和临床表现之间的关联。
方法：对50例原发性SS(pSS)患者进行检查。由风湿病学家进行临床评估和电生理研究。收集实验室测试结果的数据。对照组由50名性别和年龄相匹配的骨关节炎（OA）患者组成。
结果：研究组50例患者中有27例（54%）被诊断为CTS。对照组50人的CTS患病率为8％。在患有CTS的pSS患者中，关节受累并不比非CTS组患者更常见[15vs.13(p=0.945)]。睡眠障碍存在预期差异[18vs.9（p=0.012）]和感觉异常[23vs.13(p=0.024)]。主要发现是β2-微球蛋白（B2MG）升高的显着差异[23vs.13(p=0.024)]。其他研究因素，在文献中建议在pSS相关的神经病中具有重要意义，组间没有统计学差异。
结论：我们的研究证实，CTS在pSS患者中比在一般人群中更普遍，并提示需要一种新的方法来治疗这种现象的发病机制。我们假设CTS比关节受累更与整体疾病活动相关。
方法：对50例原发性SS(pSS)患者进行检查。由风湿病学家进行临床评估和电生理研究。收集实验室测试结果的数据。对照组由50名性别和年龄相匹配的骨关节炎（OA）患者组成。
结果：研究组50例患者中有27例（54%）被诊断为CTS。对照组50人的CTS患病率为8％。在患有CTS的pSS患者中，关节受累并不比非CTS组患者更常见[15vs.13(p=0.945)]。睡眠障碍存在预期差异[18vs.9（p=0.012）]和感觉异常[23vs.13(p=0.024)]。主要发现是β2-微球蛋白（B2MG）升高的显着差异[23vs.13(p=0.024)]。其他研究因素，在文献中建议在pSS相关的神经病中具有重要意义，组间没有统计学差异。
结论：我们的研究证实，CTS在pSS患者中比在一般人群中更普遍，并提示需要一种新的方法来治疗这种现象的发病机制。我们假设CTS比关节受累更与整体疾病活动相关。
