经典迷幻药,包括麦角酰二乙胺(LSD),psilocybin,mescaline,N,N-二甲基色胺(DMT)和5-甲氧基-N,N-二甲基色胺(5-MeO-DMT),是有效的精神活性物质,已被研究其生理和心理影响。然而,我们对这些药物与其他药物联合使用时的潜在相互作用和结果的理解有限.本系统综述旨在全面概述当前关于经典迷幻药与人类其他药物之间药物-药物相互作用的研究。我们使用多个数据库进行了彻底的文献检索,包括PubMed,PsycINFO,WebofScience和其他来源,以补充我们对相关研究的搜索。共筛选7102条记录,包括涉及人类数据的研究,这些数据描述了经典迷幻药和其他药物之间的潜在相互作用(以及缺乏相互作用)。总的来说,我们从2023年9月2日之前发表的36份报告中确定了52项研究,包括32项关于LSD的研究,10在psilocybin上,4在mescaline上,3在DMT上,2在5-MeO-DMT上,1在ayahuasca上。这些研究为经典迷幻药和一系列药物之间的相互作用提供了见解,包括抗抑郁药,抗精神病药,抗焦虑药,情绪稳定剂,娱乐药物和其他。研究结果表明,当迷幻药与其他药物结合使用时,会产生各种影响,包括减弱和增强效应,以及没有观察到变化的情况。除了一些病例报告,纳入的研究未描述严重的药物不良事件.对结果进行了深入的讨论,以及对观察到的效应的潜在分子途径的探索。
Classic psychedelics, including lysergic acid diethylamide (LSD), psilocybin, mescaline, N,N-dimethyltryptamine (DMT) and 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), are potent psychoactive substances that have been studied for their physiological and psychological effects. However, our understanding of the potential interactions and outcomes when using these substances in combination with other drugs is limited. This systematic
review aims to provide a comprehensive overview of the current research on drug-drug interactions between classic psychedelics and other drugs in humans. We conducted a thorough literature search using multiple databases, including PubMed, PsycINFO, Web of Science and other sources to supplement our search for relevant studies. A total of 7102 records were screened, and studies involving human data describing potential interactions (as well as the lack thereof) between classic psychedelics and other drugs were included. In total, we identified 52 studies from 36 reports published before September 2, 2023, encompassing 32 studies on LSD, 10 on psilocybin, 4 on mescaline, 3 on DMT, 2 on 5-MeO-DMT and 1 on
ayahuasca. These studies provide insights into the interactions between classic psychedelics and a range of drugs, including antidepressants, antipsychotics, anxiolytics, mood stabilisers, recreational drugs and others. The findings revealed various effects when psychedelics were combined with other drugs, including both attenuated and potentiated effects, as well as instances where no changes were observed. Except for a few case reports, no serious adverse drug events were described in the included studies. An in-depth discussion of the results is presented, along with an exploration of the potential molecular pathways that underlie the observed effects.