avascular necrosis

血管坏死
  • 文章类型: Journal Article
    目的:这项回顾性研究旨在评估小儿股骨颈骨折的手术效果并确定影响因素。
    方法:纳入23例接受股骨颈骨折手术治疗的儿科患者共25髋。包含患者人口统计信息的数据,骨折类型,外科技术,并发症,并对随访结果进行回顾性分析.骨折位移等因素,手术时机,固定方法,并对术后并发症进行复位质量评估。
    结果:从高处坠落占创伤机制的48%,血管坏死(AVN)是最常见的并发症(4髋)。虽然骨折位移,还原质量差,延迟手术在复杂病例中更为常见,没有达到统计学意义。该研究注意到缺血性坏死的存在与更差的临床结果之间的关联(rho:0.428,p:0.05,CI:95%)。
    结论:手术治疗取得了良好的临床效果;然而,由于研究的回顾性设计的局限性,样本量有限,单中心方法强调了更大的多中心研究的必要性。我们的研究结果强调需要进行全面的调查,以更好地了解和管理小儿股骨颈骨折,特别是关于影响AVN和长期结果的因素。
    OBJECTIVE: This retrospective study aimed to evaluate surgical outcomes and identify influential factors in pediatric femoral neck fractures.
    METHODS: A total of 25 hips from 23 pediatric patients who underwent surgical intervention for femoral neck fractures were included. Data encompassing patient demographics, fracture types, surgical techniques, complications, and follow-up outcomes were analyzed retrospectively. Factors such as fracture displacement, timing of surgery, fixation methods, and reduction quality were assessed concerning postoperative complications.
    RESULTS: Falling from a height accounted for 48% of the trauma mechanisms, and avascular necrosis (AVN) was the most prevalent complication (4 hips). Although fracture displacement, bad reduction quality, and delayed surgery were more common among complicated cases, statistical significance was not attained. The study noted an association between presence of avascular necrosis and worse clinical results(rho: 0.428, p: 0.05, CI: 95%).
    CONCLUSIONS: Surgical treatment yielded favorable clinical outcomes; however, limitations due to the study\'s retrospective design, limited sample size, and single-center approach underscore the necessity for larger multicenter studies. Our findings emphasize the need for comprehensive investigations to better understand and manage pediatric femoral neck fractures, especially regarding factors influencing AVN and long-term outcomes.
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  • 文章类型: Journal Article
    背景:股骨颈囊内骨折占髋部骨折的大部分。本研究旨在探讨外翻截骨术作为15-60岁成人股骨颈囊内骨折的主要治疗方法。评估其对功能结局和骨折愈合的影响。方法对创伤骨科进行回顾性临床分析,奥斯曼尼亚政府总医院,海得拉巴,印度,主要针对股骨粗隆间外翻截骨术治疗股骨颈囊内骨折的患者。该研究回顾了六名年龄在15至60岁之间的患者的医学图表和X光片,诊断为近期孤立性囊内股骨颈骨折,在2019年5月至2021年10月之间提交。干预涉及Pauwels转子间外翻截骨术,采用各种固定方法。主要结果指标包括射线照相结合,通过Harris髋关节评分评估的功能能力,并评估并发症。结果6例患者均在骨折和截骨部位获得X线愈合,成功率达到100%。平均随访时间为14.8个月(12-20个月),从手术到影像学愈合的平均时间为5.1个月(2.5-6个月)。一名患者经历了倒退的结合,而另一名患者则根据研究结论发展为无血管坏死(AVN)。没有观察到硬件故障或不连接的实例。在最近的临床随访中获得的平均Harris髋关节评分为84,范围为69至94。到随访期结束时,所有六名患者在没有任何支持的情况下恢复了独立行走能力。结论原发性Pauwels股骨转子间外翻截骨术联合固定角度钢板治疗是治疗近期股骨颈囊内骨折的一种高效方法。导致患者队列之间实现联合的成功率为100%。
    Background Intracapsular femoral neck fractures account for a majority of hip fractures. This study aimed to investigate the efficacy of valgus osteotomy as a primary treatment for intracapsular femoral neck fractures in adult patients aged 15-60 years, assessing its impact on functional outcomes and fracture union. Methodology A retrospective clinical analysis was conducted at the Department of Orthopedics and Traumatology, Osmania Government General Hospital, Hyderabad, India, focusing on patients treated with primary intertrochanteric valgus osteotomy for intracapsular femoral neck fractures. The study reviewed medical charts and radiographs of six patients aged between 15 and 60 years, diagnosed with recent isolated intracapsular femoral neck fractures, presenting between May 2019 and October 2021. The intervention involved Pauwels\' intertrochanteric valgus osteotomy with various fixation methods. Main outcome measures included radiographic union, functional ability assessed by the Harris Hip Score, and evaluation for complications. Results All six patients achieved radiographic union at fracture and osteotomy sites, totaling a 100% success rate. The average follow-up duration was 14.8 months (12-20 months), with an average time of 5.1 months (2.5-6 months) from surgery to radiographic union. One patient experienced union with retroversion, while another developed avascular necrosis (AVN) by the study\'s conclusion. No instances of hardware failure or non-union were observed. The average Harris Hip Score obtained during the most recent clinical follow-up was 84, ranging from 69 to 94. All six patients regained independent walking ability without any support by the end of the follow-up period. Conclusion The combination of primary Pauwels\' intertrochanteric valgus osteotomy with fixed-angle plating proves to be a highly effective method for addressing recent intracapsular femoral neck fractures, resulting in a 100% success rate in achieving union among the patient cohort.
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  • 文章类型: Journal Article
    大约20%的肱骨近端骨折(PHFs)不稳定和/或明显移位,因此需要手术。解剖复位后的锁定钢板固定已成为活跃人群中这些骨折的当前选择。然而,研究显示并发症发生率高达36%,如减少和血管坏死的损失。迄今为止,来自文献的数据对PHF中使用髓内腓骨同种异体移植物后的结果尚无定论,可能是由于案件的混合。假设在内侧铰链明显移位且不稳定的情况下,使用同种异体腓骨移植物有利于防止骨折的二次移位。导致更好的临床和患者报告的结果。
    在这项多中心配对队列研究中,不稳定的患者,位移PHF,包括解剖颈部骨折和明显移位的外科颈部骨折,包括在内。接受同种异体腓骨移植增强锁定板治疗的患者与没有同种异体移植的锁定板重建患者相匹配。比赛是根据骨折特征进行的,年龄,和性能状态。功能成果,患者报告的结果指标,并发症,和射线照相结果进行了比较。
    包括12例同种异体腓骨移植增强的骨合成患者,并与12例对照患者相匹配。同种异体腓骨移植组的平均年龄为58岁,而对照组为62岁。最短随访时间为12个月。臂肩和手的残疾评分,恒定肩关节评分,绑架,同种异体腓骨移植组和外旋转明显更好(17.4±8.6vs.26.1±19.2,P=.048;16.5±11.5vs.19.8±16.5P=.040;平均127°±38°vs.平均92°±49°P=-.045;50°±21°vs.平均26°±23°,P=.004)。两组之间的牛津肩评分无统计学差异(P=.105)。视觉模拟量表在组间没有显着差异(3.1±1.8vs.1.6±1.9,P=.439)。腓骨同种异体移植组的11例患者达到了影像学愈合,而对照组为8例(P=.317)。并发症发生率是对照组的两倍(3vs.7).
    在不稳定的PHF中,内侧铰链的额外支撑与同种异体腓骨移植相结合,似乎可以产生更稳定的结构,而不会损害头部关节表面的生存能力。因此,在选定的复杂病例中使用同种异体腓骨移植物可以获得更好的临床结果,并发症发生率较低。
    UNASSIGNED: About 20% of proximal humerus fractures (PHFs) are unstable and/or markedly displaced and therefore require surgery. Locking plate fixation after anatomical reduction has become the current treatment of choice for these fractures in the active population. However, studies have shown complication rates up to 36%, such as loss of reduction and avascular necrosis. To date, data from literature are inconclusive on outcomes following the use of an intramedullary fibula allograft in PHFs, possibly due to the case mix. It is hypothesized that the use of a fibula allograft is beneficial to prevent secondary displacement of the fracture in cases where the medial hinge is markedly displaced and unstable, resulting in better clinical and patient reported outcomes.
    UNASSIGNED: In this multicenter matched cohort study, patients with an unstable, displaced PHF, including anatomic neck fractures and significantly displaced surgical neck fractures, were included. Patients that were treated with a locking plate augmented with a fibula allograft were matched to patients who had undergone locking plate reconstruction without the allograft. The matches were made based on fracture characteristics, age, and performance status. Functional outcomes, Patient Reported Outcome Measures, complications, and radiographic results were compared.
    UNASSIGNED: Twelve patients with fibula allograft augmented osteosyntheses were included and matched to 12 control patients. The mean age was 58 years in the fibula allograft group compared to 62 years in the control group. Minimum follow-up was 12 months. Disability of the Arm Shoulder and Hand score, Constant Shoulder score, abduction, and external rotation were significantly better in the fibula allograft group (17.4 ± 8.6 vs. 26.1 ± 19.2, P = .048; 16.5 ± 11.5 vs. 19.8 ± 16.5 P = .040; mean 127° ± 38° vs. mean 92° ± 49° P = -.045; 50° ± 21° vs. mean 26° ± 23°, P = .004). There was no statistically significant difference in the Oxford Shoulder score between groups (P = .105). The Visual Analog Scale was not significantly different between groups (3.1 ± 1.8 vs. 1.6 ± 1.9, P = .439). Radiographic union was reached in 11 patients of the fibula allograft group compared to 8 in the control group (P = .317). The complication rate was twice as high in the control group (3 vs. 7).
    UNASSIGNED: Additional support of the medial hinge in unstable PHFs with a locking plate in combination with a fibula allograft appears to create a more stable construct without compromising the viability of the articular surface of the head. The use of a fibula allograft in selected complex cases could therefore result in better clinical outcomes with lower complication rates.
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  • 文章类型: Journal Article
    背景:骨坏死是系统性红斑狼疮(SLE)患者发病的主要原因。尽管岩心减压是一种被认可和可信的技术,可以防止关节进一步恶化,这种手术方法似乎对SLE患者不利.我们的目的是评估髓芯减压治疗原发性股骨头坏死的SLE患者的疗效。
    方法:在本研究中,23例(39个受影响的髋关节)股骨头坏死的II期疾病,基于Ficat-Arlet分类系统,进行岩心减压。此外,患者的人口统计学特征,临床资料,用药史,合并症,免疫学发现,髋部平片,核心减压后全髋关节置换术的历史,根据牛津髋关节评分问卷获得患者对关节功能的满意度。
    结果:在研究中,53.8%的受影响关节在随访成像中显示出影像学恶化的迹象。61%(61.5%)的患者关节性能不理想。三分之一(33.3%)的受影响的髋关节在核心减压后5年内接受了全髋关节置换术。有双膦酸盐治疗史的SLE患者对关节功能的不满比没有双膦酸盐治疗史的患者低83.2%(P<0.02)。在23个研究案例中,核心减压手术前后泼尼松龙的平均累积剂量分别为46.41mg和14.74mg.此外,1例(2.6%)在随访期间抗磷脂抗体水平较高的病例没有任何放射学恶化,9例(23.1%)有一定程度的影像学恶化。
    结论:使用双膦酸盐的患者组,核心减压后关节功能满意度较高。具有高水平抗磷脂抗体的患者与核心减压后的不良预后有关。
    Osteonecrosis is a major cause of morbidity for patients with systemic lupus erythematosus (SLE). Although core decompression is an approved and trusted technique to prevent further joint deterioration, this surgical method seems to be less beneficial for SLE patients. We aimed to evaluate the outcomes of core decompression in SLE patients with primary stages of femoral head osteonecrosis.
    In this study, 23 patients (39 affected hip joints) with osteonecrosis of the femoral head with stage II of the disease, based on the Ficat-Arlet classification system, underwent core decompression. Also, patients demographic characteristics, clinical data, medication history, comorbidities, immunological findings, hip plain radiographs, history of total hip arthroplasty after core decompression, and patients satisfaction with joint function according to the Oxford hip score questionnaire were obtained.
    In the study, 53.8% of affected joints showed signs of radiographic deterioration in follow-up imaging. Sixty-one and a half percent (61.5%) of patients had unsatisfactory joint performance. A third (33.3%) of affected hip joints underwent total hip arthroplasty up to 5 years from core decompression. SLE patients with a history of receiving bisphosphonate were 83.2% less dissatisfied with their joint function than patients without a history of bisphosphonate use (P < 0.02). Of the 23 studied cases, the mean cumulative dose of prednisolone before and after core decompression surgery was 46.41 mg and 14.74 mg respectively. Besides, one case (2.6%) that had a high anti-phospholipid antibodies level during follow-up did not have any radiographic deterioration, and 9 cases (23.1%) had some degrees of radiographic deterioration.
    The patients group that used bis-phosphonate, had a higher level of satisfaction with joint function after core decompression. Patients with high-level anti-phospholipid antibodies are related to a poor prognosis after core decompression.
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  • 文章类型: Journal Article
    目前的文献没有明确证明任何特定的舟骨重建方法的优越性。这项回顾性单中心研究的主要目标是评估重建技术和其他因素对舟骨骨不连重建后愈合率的影响。在研究中,纳入了370例根据腕骨对齐分为稳定(Mayo1)或不稳定(Mayo2)的不愈合患者。最少的放射学随访为3个月。使用294例计算机断层扫描和76例患者的X线照片评估了舟骨重建后的骨愈合。在分析中应用了单变量和多变量逻辑回归。影响愈合率的八个有统计学意义的因素是固定方法,以前的操作类型,所有操作的数量,重建的数量,吸烟,术后病理性外侧肩胛骨内角(LISA>45°),缺血性坏死(AVN),和不工会的稳定性。吸烟和术后LISA>45°显著降低骨融合概率约4.4和9.5倍,分别。骨不连部位血管减少的患者骨融合的机会降低了5.2倍。我们的多变量逻辑回归模型可以解释舟骨重建后32%的失败,包括术后LISA>45°,患者目前的吸烟记录,减少骨不连部位的血管分布。然而,骨移植类型一般不影响愈合率;然而,在AVN的情况下,与其他类型的移植物(非血管化和带蒂骨移植物视为一组,p=0.09)。
    Current literature does not definitely demonstrate the superiority of any particular scaphoid reconstruction method. The primary goal of this retrospective single center study was to evaluate the influence of reconstruction techniques and other factors on the union rate after reconstruction of scaphoid nonunions. In the study, 370 patients with nonunions classified as stable (Mayo 1) or unstable (Mayo 2) depending on carpal alignment were included. Minimal radiological follow-up was 3 months. Bone healing after scaphoid reconstruction was evaluated using computer tomography scans in 294 and radiograms in 76 patients. Univariate and multivariate logistic regressions were applied in the analysis. Eight statistically significant factors that influenced the union rate were fixation method, type of previous operations, number of all operations, number of reconstructions, smoking, postoperative pathological lateral intrascaphoid angle (LISA>45°), avascular necrosis (AVN), and stability of nonunion. Smoking and postoperative LISA>45° significantly reduced the probability of bone fusion by approximately 4.4 and 9.5 times, respectively. Patients with reduced vascularity in the nonunion site had a 5.2 times lower chance of bone fusion. Our multivariate logistic regression model can explain 32% of failures after scaphoid reconstruction, including postoperative LISA>45°, patients\' present record of smoking, and reduced vascularity in the nonunion site. However, bone graft type does not impact the union rate in general; however, in case of AVN, the tendency toward higher union rates was observed for medial femoral condyle free flaps when compared to other types of graft (non-vascularized and pedicled bone grafts considered as one group, p = 0.09).
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  • 文章类型: Journal Article
    目的:股骨头缺血性坏死是一种常见于中年人的疾病。尽管许多病因被指责,仍然有病因因素尚未完全阐明。尽管治疗选择范围广泛,早期和适当的治疗对保留髋关节非常重要。在我们的研究中,我们比较了髓芯减压和髓芯减压联合骨髓间充质干细胞植入治疗股骨头缺血性坏死的结果。
    方法:在这项回顾性研究中,分析了2018年至2023年接受股骨头缺血性坏死手术的Steinberg1-2期患者。分别由接受孤立核减压和核减压+骨髓间充质干细胞植入的患者组成。年龄,性别,斯坦伯格分期,病因学的疾病,随访期,进展为髋关节置换术,Vas分数,哈里斯髋关节评分(HHS),并对并发症进行了评估。术前和2年随访期间Harris髋关节评分;术前VAS评分,3个月,6个月,1年,和2年的随访期进行了分析。
    结果:在研究中,对44例患者进行了分析。而25例患者仅接受核心减压(第1组),19例患者行核心减压和骨髓间充质干细胞植入(第2组)。第1组患者的平均年龄为39.3±6.5岁,第2组患者的平均年龄为38.4±6.7岁。第1组的平均随访时间为31.85±4.4个月,第2组的平均随访时间为32.2±4.1个月。第1组中的2例患者进行了全髋关节置换术(其中一名患者在第28个月接受了全髋关节置换术,另一名在第33个月接受了全髋关节置换术)。
    结论:股骨头缺血性坏死的治疗方法因分期方法而异。疾病的早期诊断和正确的治疗对患者今后的生活质量非常重要。在我们的研究中,我们发现接受髓芯减压和干细胞植入治疗早期股骨头缺血性坏死的患者在6个月时疼痛减轻,1年,和2年的随访检查。此外,根据HHS评估,他们的髋关节功能在24个月时有所改善。
    OBJECTIVE: Avascular necrosis of the femoral head is a disease usually seen in middle-aged individuals. Although many aetiological factors have been blamed, there are still aetiological factors that have not been fully elucidated. Although treatment options show a wide range, early and appropriate treatment is of great importance to preserve the hip joint. In our study, we compared the results of core decompression and core decompression combined with bone marrow mesenchymal stem cell implantation in patients with avascular necrosis of the femoral head.
    METHODS: In this retrospective study, Steinberg stage 1-2 patients operated on for avascular necrosis of the femoral head between 2018 and 2023 were analysed. Separate groups were formed from patients who underwent isolated core decompression and core decompression + bone marrow mesenchymal stem cell implantation. Age, gender, Steinberg staging, aetiology of the disease, follow-up period, progression to hip arthroplasty, Vas scores, Harris hip scores (HHS), and complications were evaluated. Harris hip scores at preoperative and 2-year follow-up periods; VAS scores at preoperative, 3-month, 6-month, 1-year, and 2-year follow-up periods were analysed.
    RESULTS: In the study, 44 patients were analysed. While 25 patients underwent core decompression only (group 1), 19 patients underwent core decompression and bone marrow mesenchymal stem cell implantation (group 2). The mean age of the patients in group 1 was 39.3 ± 6.5 years, and the mean age of the patients in group 2 was 38.4 ± 6.7 years. The mean follow-up was 31.85 ± 4.4 months in group 1 and 32.2 ± 4.1 months in group 2. Total hip arthroplasty was performed in 2 of the patients in group 1 (one of the patients underwent total hip arthroplasty at month 28 and the other at month 33).
    CONCLUSIONS: The treatment of avascular necrosis of the femoral head varies according to various staging methods. Early diagnosis of the disease and correct treatment are very important for the patient\'s quality of life in the future. In our research, we found that patients who received both core decompression and stem cell implantation for early-stage avascular necrosis of the femoral head exhibited decreased pain at the 6-month, 1-year, and 2-year follow-up examinations. Additionally, their hip function improved at the 24-month mark according to the HHS evaluation.
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  • 文章类型: Journal Article
    目的:舟骨骨不连治疗仍是非自愿的,基于血管化或非血管化的骨移植。这项研究旨在通过长期随访来评估功能,临床,和放射学结果,报告了并发症和再次手术,并研究了不愈合治疗的预后因素。
    方法:对因舟骨骨不连而接受植骨手术的患者进行回顾性分析。评估的结果是疼痛,qDASH,PRWE和MWS得分,活动范围,握力,联合汇率,肩胛骨角,腕骨高度,和关节病的存在。还报告了并发症和再干预措施。
    结果:本研究包括60例舟骨骨不连治疗,平均随访7.7年(1.5-20.3年)。20个(33.3%)不结合位于近端极点,其中6例(10%)为术前血管坏死(AVN)。合并发生在51例(85%)。功能,临床,放射学结果良好。并发症发生率为21.3%,再干预率为16.7%。如果不愈合位于近端极或存在AVN,则亚组愈合率分析没有发现差异。
    结论:具有代表性的人群样本和长期随访,我们找到了一个很好的联合率,无论选择何种治疗方法,临床和功能结果。舟骨骨不连的治疗仍然存在争议,需要更多的研究来根据患者和骨不连的特点准确地适应每种移植物。
    方法:回顾性队列研究。
    OBJECTIVE: Scaphoid non-union treatment remains nonconsensual and is based on vascularized or non-vascularized bone grafting. This study aimed to evaluate with a long follow-up the functional, clinical, and radiological outcomes, reported complications and reoperations and studied non-union treatment prognostic factors.
    METHODS: Patients who had undergone bone graft surgery for scaphoid non-union were retrospectively reviewed. The evaluated outcomes were pain, qDASH, PRWE and MWS scores, active range of motion, grip strength, union rate, scapholunate angle, carpal height, and presence of arthrosis. Complications and reinterventions were also reported.
    RESULTS: This study included 60 scaphoid non-union treatments with a mean follow-up of 7.7 (1.5-20.3) years. Twenty (33.3%) non-unions were located at the proximal pole, including 6 (10%) with preoperative avascular necrosis (AVN). Union occurred in 51 patients (85%). The functional, clinical, and radiological results were good. The complication rate was 21.3% and the reintervention rate was 16.7%. Subgroup union rate analysis found no difference if the non-union is localized in the proximal pole or if there is AVN.
    CONCLUSIONS: With a representative sample of the population and a long follow-up, we have found a good union rate, clinical and functional results regardless of the treatment method chosen. Scaphoid non-union treatment is still controversial and more studies are needed to accurate indications of each graft according to the patient and non-union characteristics.
    METHODS: Retrospective cohort study.
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  • 文章类型: Randomized Controlled Trial
    背景:缺血性坏死的风险,骨不连,或不愈合在骨质疏松症相关的四部分骨折中很高。我们试图评估接受血管化胸大肌钢板内固定术的患者的结果,与三皮质髂骨移植治疗4部分肱骨近端骨折相比。
    方法:研究了34例年龄在50-75岁之间的Neer4段肱骨近端骨折患者。A组(n=17)行2.5cm±1cm胸大肌椎弓根植骨截骨并应用钢板,而B组(n=17)使用自体骨移植物进行钢板接骨术。最终的随访评估包括使用恒定和美国肩肘外科医生评分系统进行评估,肱骨颈-轴角(HNSA),肱骨头高度(肱骨头高度)和肱骨头缺血性坏死。
    结果:尽管在A组患者中有3例患者(17.6%)观察到减少损失,B组中有10例患者(58.8%)观察到减少损失,p=0.013。A组肱骨头缺血性坏死1例(5.8%),而另一组为5(29.4%)(p=0.071)。A组12例(70.5%)患者HNSA正常,而B组6例(35.2%)患者正常。29.4%的A组患者HNSA弱或差(<1200),而B组患者的这一比率为64.7%。A组HHH为2.64±1.45mm,B组HHH为3.66±1.65mm,两组在常数和美国肩肘外科医生评分系统方面无统计学差异。
    结论:在Neer4部分肱骨近端骨折中,胸大肌骨移植可降低缺血性坏死和骨不愈合的风险。我们的技术产生了出色的临床和放射学结果。我们在没有造成额外供体部位发病率的情况下实现了康复。
    BACKGROUND: The risk of avascular necrosis, nonunion, or malunion is high in osteoporosis-related 4-part fractures. We evaluated the results of patients who underwent plate osteosynthesis with a vascularized pectoralis major graft compared with tricortical iliac grafting to treat 4-part proximal humerus fractures.
    METHODS: Thirty-four patients aged 50-75 years with Neer 4-part proximal humerus fractures were studied. Group A (n = 17) underwent osteotomy of a 2.5 ± 1 cm pectoralis major pedicle bone graft and plate application, whereas group B (n = 17) underwent plate osteosynthesis using iliac autogenous grafts. Final follow-up assessments included evaluation using Constant and American Shoulder and Elbow Surgeons scoring systems, humeral neck-shaft angle (HNSA), humeral head height, and humeral head avascular necrosis.
    RESULTS: Reduction loss was observed in 3 patients (17.6%) in group A, whereas it was observed in 10 patients (58.8%) in group B (P = .013). Humeral head avascular necrosis was found in 1 patient (5.8%) in group A, whereas it was found in 5 patients (29.4%) in the other group (P = .071). The HNSA was normal in 12 (70.5%) of group A patients, whereas it was normal in 6 (35.2%) of group B patients. The HNSA was weak or bad (<1200) in 29.4% of group A patients, whereas this rate was 64.7% in group B patients. Humeral head height was 2.64 ± 1.45 mm in group A and 3.66 ± 1.65 mm in group B. There were no statistically significant differences between the 2 groups in terms of Constant and American Shoulder and Elbow Surgeons scoring systems.
    CONCLUSIONS: Pectoralis major bone pedicle graft in Neer 4-part proximal humerus fractures reduces the risk of avascular necrosis and nonunion rates. Our technique yielded excellent clinical and radiological results. We achieved recovery without creating additional donor site morbidity.
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  • 文章类型: Journal Article
    背景:多项研究表明,在接受全髋关节置换术的骨坏死(ON)患者中,并发症发生率很高。然而,关于ON患者全膝关节置换术(TKA)结局的文献很少.我们的研究旨在评估与ON发展相关的术前危险因素,并确定TKA术后长达一年的术后并发症发生率。
    方法:使用大型国家数据库进行回顾性队列研究。分别使用当前程序术语代码27447和ICD-10-CM代码M87分离患有原发性TKA和ON的患者。使用ICD-10-CM代码M87.06进行子分析。使用1:1倾向评分匹配函数来创建具有匹配的基线特征的队列。总共确认了185,045名患者,包括181,151名患有TKA的患者和3,894名患有TKA和ON的患者。在倾向匹配之后,两组各有3,758例患者.使用比值比对倾向评分匹配后的主要和次要结局进行队列间比较。<0.01的P值被确定为是显著的。
    结果:发现ON患者发生人工关节感染的风险增加,尿路感染,深静脉血栓形成,肺栓塞,伤口裂开性肺炎,以及不同时间点异位骨化的发展。ON患者在1年时间点的翻修风险增加(赔率比=2.068,P<0.0001)。
    结论:ON患者发生全身和关节并发症的风险高于非ON患者。这些并发症表明在TKA之前和之后有ON的患者的治疗过程更为复杂。
    BACKGROUND: Several studies have demonstrated high complication rates in osteonecrosis (ON) patients undergoing total hip arthroplasty. However, there is a paucity of literature regarding outcomes of total knee arthroplasty (TKA) in ON patients. Our study aimed to assess preoperative risk factors associated with the development of ON and determine the incidence of postoperative complications up to one year following TKA.
    METHODS: A retrospective cohort study was conducted using a large national database. Patients who had a primary TKA and ON were isolated using Current Procedural Terminology code 27447 and ICD-10-CM code M87, respectively. A total of 185,045 patients were identified, including 181,151 patients who had a TKA and 3,894 patients who had a TKA and ON. After propensity matching, both groups each contained 3,758 patients. Intercohort comparisons of primary and secondary outcomes after propensity score matching were made using the odds ratio. A P value of < .01 was determined to be significant.
    RESULTS: The ON patients were found to have an increased risk for prosthetic joint infection, urinary tract infection, deep vein thrombosis, pulmonary embolism, wound dehiscence pneumonia, and the development of heterotopic ossification at different time points. Osteonecrosis patients had an increased risk of revision at the 1-year time point (odds ratio = 2.068, P < .0001).
    CONCLUSIONS: The ON patients had a higher risk of systemic and joint complications than non-ON patients. These complications suggest a more complicated management course for patients who have ON prior to and after TKA.
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  • 文章类型: Multicenter Study
    背景:血管坏死是SLE患者常见的器官损害,这会影响患者的生活质量。SLE患者AVN的危险因素存在冲突结果。这项研究的目的是说明预测缺血性坏死(AVN)发生的危险因素,也被称为骨坏死,在系统性红斑狼疮(SLE)患者中,中国SLE治疗和研究组(CSTAR),中国SLE患者的多中心队列。
    方法:纳入注册时无AVN的CSTARSLE患者。对于AVN事件需要至少两次随访和不少于2年的观察期。单因素和多因素Cox回归分析用于评估SLE患者AVN的危险因素。将系数B转换为风险评分,以开发风险分层模型。
    结果:4091例SLE患者中有106例(2.59%)在不少于2年的随访中被诊断为AVN。多变量Cox回归分析提示SLE发病年龄≤30岁(HR1.616,p0.023),关节炎(HR1.642,p0.018),注册时存在的器官损伤(SDI≥1)(HR2.610,p<0.001),阳性抗RNP(HR1.709,p0.006),注册时高糖皮质激素最大日剂量(HR1.747,p0.02)是独立的危险因素。根据风险因素制定了风险分层系统,将患者分为高危(3-6)和低危(0-2)。0.692的AUC表明中度歧视。绘制内部验证中的校准曲线。
    结论:SLE患者发病年龄≤30岁,关节炎,登记时现有器官损伤(SDI≥1),阳性抗RNP,注册时高糖皮质激素最大日剂量是AVN的高风险,需要注意。
    Avascular necrosis is a common organ damage in SLE patients, which can influence patients\' life quality. Conflicting results exist in risk factors of AVN in SLE patients. The aim of this study was to illustrate risk factors predicting the occurrence of avascular necrosis (AVN), also known as osteonecrosis, in systemic lupus erythematosus (SLE) patients in Chinese SLE Treatment and Research Group (CSTAR), a multi-center cohort of Chinese SLE patients.
    SLE patients in CSTAR without existing AVN at registration were included. At least two follow-ups and an observation period of no less than 2 years for AVN event were required. Univariate and multivariate Cox regression analyses were used to evaluate risk factors for AVN in SLE patients. Coefficient B was transformed to risk score for the development of a risk stratification model.
    One hundred six (2.59%) of 4091 SLE patients were diagnosed AVN during follow-ups of no less than 2 years. Multi-variate Cox regression analysis suggested that SLE onset age ≤ 30 (HR 1.616, p 0.023), arthritis (HR 1.642, p 0.018), existing organ damage (SDI ≥ 1) at registration (HR 2.610, p < 0.001), positive anti-RNP (HR 1.709, p 0.006), and high glucocorticoid maximum daily dose at registration (HR 1.747, p 0.02) were independent risk factors. A risk stratification system was developed according to the risk factors, and patients were divided into high risk (3-6) and low risk (0-2). The AUC of 0.692 indicated moderate discrimination. The calibration curve in internal validation was drawn.
    Patients with SLE onset age ≤ 30, arthritis, existing organ damage (SDI ≥ 1) at registration, positive anti-RNP, and high glucocorticoid maximum daily dose at registration are at high risk for AVN and require attention.
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