背景:芹菜素越来越被认为是癌症化学预防剂。我们旨在研究Apigenin在体内研究中的抗癌作用,以了解其目前的研究状况以及与临床的距离或距离。
方法:几个电子数据库,如PubMed、Springer,科克伦,和ctric.gov在进行搜索以获取相关文章。我们只关注已发表的动物研究,这些研究报道了芹菜素对各种癌症的抗癌作用。两名评审员独立评估了每项分析的偏倚风险,矛盾的观点后来以协商一致的方式得到解决。
结果:共有25项研究集中于芹菜素对各种癌症类型的抗癌作用,包括肝脏,前列腺,胰腺,肺,鼻咽,皮肤,结肠,结直肠,结肠炎相关癌,头颈部鳞状细胞癌,白血病,肾细胞癌,艾氏腹水癌,包括乳腺癌。总的来说,芹菜素可减少肿瘤体积(SMD=-3.597,95%CI:-4.502至-2.691,p<0.001),肿瘤重量(SMD=-2.213,95%CI:-2.897至-1.529,p<0.001),肿瘤数量(SMD=-1.081,95%CI:-1.599至-0.563,p<0.001)和肿瘤负荷(SMD=-1.556,95%CI:-2.336至-0.776,p<0.001)。Further,对动物体重无显著影响(SMD=-0.345,95%CI:-0.832~0.143,p=0.165)。芹菜素主要通过诱导细胞凋亡/细胞周期阻滞发挥抗肿瘤作用。
结论:我们的分析表明,芹菜素对各种癌症具有潜在的抗癌作用。然而,漏斗图对称性差,提示发表偏倚.因此,值得进一步研究以评估芹菜素单独或作为癌症治疗佐剂的潜力。
BACKGROUND: Apigenin is being increasingly recognized as a cancer chemopreventive agent. We aimed to investigate the anticancer effects of
Apigenin in in-vivo studies to know its present research status and how close or how far it is from the clinics.
METHODS: Several electronic databases such as PubMed, Springer, Cochrane, and ctri.gov.in were searched to fetch the relevant articles. We focused only on published animal studies that reported the anticancer effects of
Apigenin against various cancers. Two reviewers independently assessed the risk of bias for each analysis, and the conflicting views were resolved later by consensus.
RESULTS: A total of 25 studies focused on the anticancer effects of Apigenin on various cancer types, including liver, prostate, pancreatic, lung, nasopharyngeal, skin, colon, colorectal, colitis-associated carcinoma, head and neck squamous cell carcinoma, leukemia, renal cell carcinoma, Ehrlich ascites carcinoma, and breast cancer were included. Overall,
Apigenin reduces tumor volume (SMD=-3.597, 95% CI: -4.502 to -2.691, p < 0.001), tumor-weight (SMD=-2.213, 95% CI: -2.897 to -1.529, p < 0.001), tumor number (SMD=-1.081, 95% CI: -1.599 to -0.563, p < 0.001) and tumor load (SMD=-1.556, 95% CI: -2.336 to -0.776, p < 0.001). Further, it has no significant effect on the animal\'s body-weight (SMD=-0.345, 95% CI: -0.832 to 0.143, p = 0.165).
Apigenin exerts anti-tumor effects mainly by inducing apoptosis/cell-cycle arrest.
CONCLUSIONS: Our analysis suggests that Apigenin has potential anticancer effects against various cancers. However, the poor symmetry of the funnel plot suggested publication bias. Thus, it warrants further research to evaluate the potential of Apigenin alone or as an adjuvant for cancer treatment.