屈指肌腱损伤是快速获得的,对运动员来说很常见,建筑工人,和军事人员等,在急诊科治疗。然而,受伤的屈肌腱的愈合在长达12周的长时间内伸展,因此,仍然是一个重要的临床问题。术后并发症,出现在传统的肌腱修复策略之后,包括粘连和肌腱瘢痕组织形成,早期主动动员的机械强度不足,和感染。各种研究人员试图开发创新策略,以开发一种基于聚合物的结构,以最大程度地减少这些术后并发症,然而,没有常规用于临床实践。了解这种结构在肌腱修复中的作用应该能够实现更有针对性的方法。这篇综述主要描述了基于聚合物的构建体,它们在解决这些并发症方面显示出有希望的结果,希望有一天这些将被用作屈肌腱修复的常规练习,增加患者的福祉。此外,该综述还侧重于活性化合物在这些构建体中的掺入,为屈肌腱提供增强的愈合环境。
A flexor tendon injury is acquired fast and is common for athletes, construction workers, and military personnel among others, treated in the emergency department. However, the healing of injured flexor tendons is stretched over a long period of up to 12 weeks, therefore, remaining a significant clinical problem. Postoperative complications, arising after traditional tendon repair strategies, include adhesion and tendon scar tissue formation, insufficient mechanical strength for early active mobilization, and infections. Various researchers have tried to develop innovative strategies for developing a polymer-based construct that minimalizes these postoperative complications, yet none are routinely used in clinical practice. Understanding the role such constructs play in tendon repair should enable a more targeted approach. This
review mainly describes the polymer-based constructs that show promising results in solving these complications, in the hope that one day these will be used as a routine practice in flexor tendon repair, increasing the well-being of the patients. In addition, the
review also focuses on the incorporation of active compounds in these constructs, to provide an enhanced healing environment for the flexor tendon.