背景:内源性大麻素(EC)在胰岛素抵抗中的作用,它们与内脏肥胖和代谢谱的关系已被广泛研究。由于妊娠糖尿病(GDM)中ECs与代谢因素之间的关系尚不清楚,我们的目的是评估N-花生四烯酰乙醇胺(AEA)和2-花生四烯酰甘油(2-AG)的水平及其与C反应蛋白(CRP)的关系,血糖指数,血压,GDM孕妇的人体测量指标。
方法:本病例对照研究是在96名18-40岁的单身孕妇中进行的,包括48例健康孕妇(对照组)和48例GDM诊断阳性的妇女(病例组)。根据内源性大麻素和人体测量指标,使用多变量Logistic回归检查GDM的赔率比(OR)和95%置信区间(CI)。
结果:模型1、2和3中AEA与GDM风险增加显著相关(OR=1.22,95%CI:1.06-1.41;OR=1.54,95%CI:1.19-1.97;OR=1.46,95%CI:1.11-1.91)。模型4中AEA呈正相关,但无显著相关性(OR=1.38,95%CI:0.99-1.92)。类似于AEA,在模型1、2和3中,2-AG也与GDM的可能性呈正相关,但在模型4中,这种关联减弱为零(OR=1.25;95%CI:0.94-1.65)。
结论:我们的研究结果表明,GDM孕妇的ECs水平明显高于健康孕妇。此外,ECs水平与GDM的可能性相关,与BMI和体重增加无关。
BACKGROUND: The role of the Endocannabinoids (ECs) in insulin resistance, and their association with visceral obesity and metabolic profile have been studied extensively. Since the association between ECs and metabolic factors in Gestational Diabetes Mellitus (GDM) are not clear, we aimed to evaluate the levels of N-Arachidonoylethanolamide (AEA) and 2-Arachidonoylglycerol (2-AG) and their association with C-reactive protein (CRP), glycemic indices, blood pressure, and anthropometric indices in pregnant women with GDM.
METHODS: The present
case-control study was conducted among 96 singleton pregnant women aged 18-40 years, including 48 healthy pregnant women (control group) and 48 women with a positive diagnosis of GDM (
case group). Odds Ratios (ORs) and 95% Confidence Intervals (CIs) for GDM were checked according to endocannabinoids and anthropometric indices using Multivariable Logistic Regression.
RESULTS: AEA was significantly associated with increased risk of GDM in models 1, 2 and 3 (OR = 1.22, 95% CI: 1.06-1.41; OR = 1.54, 95% CI: 1.19-1.97; OR = 1.46, 95% CI:1.11-1.91). A positive but no significant association was found for AEA in model 4 (OR = 1.38,95% CI: 0.99-1.92). Similar to AEA, 2-AG was also positively associated with the likelihood of GDM in Models 1, 2, and 3 but the association attenuated to null in model 4 (OR = 1.25; 95% CI: 0.94- 1.65).
CONCLUSIONS: Our findings showed that levels of ECs were significantly higher in pregnant women with GDM compared to healthy ones. Also, ECs levels were associated with the likelihood of GDM, independent of BMI and weight gain.