循环内源性大麻素水平的增加通常与有氧运动有关。这种现象与“跑步者”的高有关,“长时间锻炼后,一种兴奋和幸福的状态。我们将在本综述中提供遵循PRISMA-P和Cochrane干预措施系统评价手册的透明和标准化方法,以进行系统评价和荟萃分析,以综合有关体力活动对健康受试者体内AEA和2-AG内源性大麻素循环水平影响的现有证据。
具有运动科学基础和临床专业知识的多学科团队开发了该协议。PubMed,EMBASE,WebofScience,CINAHL,SPORTDiscus,而Scopus将成为数据库.在研究的发展过程中,咨询了健康科学图书馆员。搜索策略将结合MeSH术语和自由文本单词,包括“锻炼”,\"\"练习,物理,\"\"运动训练,\"\"身体活动,“内源性大麻素,\“\”2-花生四酰基甘油,\“\”2-花生四烯酸甘油酯,\"\"2-AG,\"\"anandamide,\"\"AEA,\"\"n-花生四烯酸乙醇胺,\"\"成人,\"\"年轻的成年人,“和”中年人。“我们将选择到2021年12月发表的实验或准实验研究。研究的选择,数据提取,评估偏差的风险,证据质量将以配对和独立的方式进行,一致性将使用CohenKappa的统计数据进行评估。方法学质量将使用修订的Cochrane风险偏倚工具(RoB2)和非随机干预研究(ROBINS-I)风险工具进行评估。我们将使用建议评估等级,发展,和评估证据的质量,异质性的χ2和I2检验,漏斗图,和出版偏倚的Egger检验。将尽可能对每个数据比较进行荟萃分析,以确定体力活动对内源性大麻素循环水平的影响。
本系统综述和荟萃分析将概述有关AEA和2-AG内源性大麻素的体力活动的证据,包括研究之间变量的可比性,对结果的批判性解释,和使用准确的统计技术。内源性大麻素是肌肉与其他组织和器官交流的分子,调节运动对健康和表现的有益影响,包括葡萄糖摄取增加,改善胰岛素作用,和线粒体生物发生。它们对锻炼至关重要。因此,本研究将回顾体育锻炼对健康个体内源性大麻素循环水平的急性影响。这项研究的结果可能会转移给医生,卫生专业人员,和立法者指导他们的决策,以及将改善未来的研究。
PROSPEROCRD42020202886。
Increased circulating endocannabinoids levels are typically associated with aerobic exercise. This phenomenon is associated with a \"runner\'s high,\" a state of euphoria and well-being experienced after a long exercise. We will provide in this
review a transparent and standardized methodology following the PRISMA-P and Cochrane Handbook for Systematic Reviews of Interventions for conducting a systematic
review and meta-analysis for synthesizing the available evidence about the effects of physical activity on the circulating levels of AEA and 2-AG endocannabinoids in healthy subjects.
A multi-disciplinary team with basic and clinical expertise in exercise science developed this protocol. PubMed, EMBASE, Web of Science, CINAHL, SPORTDiscus, and Scopus will be the databases. A health sciences librarian was consulted in the development of the research. Search strategies will combine MeSH terms and free text words, including \"exercise,\" \"exercise, physical,\" \"exercise training,\" \"physical activity,\" \"endocannabinoids,\" \"2-arachidonoyl-glycerol,\" \"glyceryl 2-arachidonate,\" \"2-AG,\" \"
anandamide,\" \"AEA,\" \"n-arachidonoylethanolamide,\" \"adult,\" \"young adult,\" and \"middle-aged.\" We will select experimental or quasi-experimental studies published through December 2021. The selection of studies, data extraction, assessment of the risk of bias, and the quality of evidence will be carried out in a paired and independent manner, and the consistency will be assessed using the statistics of Cohen Kappa. Methodological quality will be assessed using the Revised Cochrane risk of bias tool for randomized trials (RoB 2) and the Risk Of Bias In Nonrandomized Studies of Interventions (ROBINS-I) risk tool. We will use the Grading of Recommendations Assessment, Development, and Evaluation to assess the quality of the evidence, χ2 and I2 tests for heterogeneity, funnel plots, and the Egger test for publication bias. A meta-analysis for each data comparison will be performed whenever possible to determine the effect of physical activity on endocannabinoids\' circulating levels.
This systematic
review and meta-analysis will provide an overview of the evidence about physical activity over AEA and 2-AG endocannabinoids, including comparability of variables between studies, critical interpretation of results, and use of accurate statistical techniques. The endocannabinoid is molecules by which muscles communicate with other tissues and organs, mediating the beneficial effects of exercise on health and performance, including increased glucose uptake, improved insulin action, and mitochondrial biogenesis. They are essential to exercise. Thus, this study will
review the acute effect of physical exercise on circulating levels of endocannabinoids in healthy individuals. The results of this study will potentially be transferred to doctors, health professionals, and legislators to guide their decision making, as well as will improve future research.
PROSPERO CRD42020202886 .