内脏肥胖指数(VAI)是内脏肥胖的可靠指标。然而,在美国成人糖尿病患者中,没有研究人员评估VAI和DKD之间的关联.Theref-ore,本研究旨在探讨两者之间的关系以及VAI是否为美国成人糖尿病患者DKD的良好诊断因子。我们的横断面研究包括2007年至2018年有资格参加国家健康和营养检查调查(NHANES)的2508名糖尿病参与者。使用单变量和多变量逻辑回归分析VAI水平与DKD之间的关联。三个模型用于控制盆栽混杂因素,进行亚组分析以进一步验证.共纳入2508例糖尿病患者,其中945人(37.68%)被诊断为DKD。总的来说,DKD组为3.36±0.18,对照组为2.76±0.11。在充分调整共同因素后,VAI与DKD呈正相关(OR=1.050,95%CI1.049,1.050)。与VAI最低三分位数的参与者相比,VAI比例最高的参与者的DKD风险显著增加35.9%(OR=1.359,95%CI1.355,1.362).通过亚组分析,我们发现在所有年龄亚组中,VAI与DKD的发生呈正相关,男性(OR=1.043,95%CI1.010,1.080),参与者了解心血管疾病(OR=1.038,95%CI1.011,1.069),高血压(OR=1.054,95%CI1.021,1.090),未婚参与者(OR=1.153,95%CI1.036,1.294),PIR<1.30(OR=1.049,95%CI1.010,1.094),PIR≥3(OR=1.085,95%CI1.021,1.160),BMI≥30kg/m2(OR=1.050,95%CI1.016,1.091),前吸烟者(OR=1.060,95%CI1.011,1.117),从未锻炼(OR=1.033,95%CI1.004,1.067),非西班牙裔白人(OR=1.055,95%CI1.010,1.106)和非西班牙裔黑人(OR=1.129,95%CI1.033,1.258)。我们的结果表明,VAI水平升高与糖尿病患者DKD的发展密切相关。VAI可能是预测DKD发生的简单且具有成本效益的指标。这需要在她的前瞻性调查中得到证实。
Visceral adiposity index (VAI) is a reliable indicator of visceral adiposity. However, no stu-dies have evaluated the association between VAI and DKD in US adults with diabetes. Theref-ore, this study aimed to explore the relationship between them and whether VAI is a good pr-edictor of DKD in US adults with diabetes. Our cross-sectional study included 2508 participan-ts with diabetes who were eligible for the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018. Univariate and multivariate logistic regression were used to an-alyze the association between VAI level and DKD. Three models were used to control for pot-ential confounding factors, and subgroup analysis was performed for further verification. A tot-al of 2508 diabetic patients were enrolled, of whom 945 (37.68%) were diagnosed with DKD. Overall, the VAI was 3.36 ± 0.18 in the DKD group and 2.76 ± 0.11 in the control group. VAI was positively correlated with DKD (OR = 1.050, 95% CI 1.049, 1.050) after fully adjusting for co-nfounding factors. Compared with participants in the lowest tertile of VAI, participants in the highest tertile of VAI had a significantly increased risk of DKD by 35.9% (OR = 1.359, 95% CI 1.355, 1.362). Through subgroup analysis, we found that VAI was positively correlated with the occurrence of DKD in all age subgroups, male(OR = 1.043, 95% CI 1.010, 1.080), participants wit-hout cardiovascular disease(OR = 1.038, 95% CI 1.011, 1.069), hypertension (OR = 1.054, 95% CI 1.021, 1.090), unmarried participants (OR = 1.153, 95% CI 1.036, 1.294), PIR < 1.30(OR = 1.049, 95% CI 1.010, 1.094), PIR ≧ 3 (OR = 1.085, 95% CI 1.021, 1.160), BMI ≧ 30 kg/m2 (OR = 1.050, 95% CI 1.016, 1.091), former smokers (OR = 1.060, 95% CI 1.011, 1.117), never exercised (OR = 1.033, 95% CI 1.004, 1.067), non-Hispanic white population (OR = 1.055, 95% CI 1.010, 1.106) and non-Hipanic black population (OR = 1.129, 95% CI 1.033, 1.258). Our results suggest that elevated VAI levels are closely associated with the development of DKD in diabetic patients. VAI may be a simpl-e and cost-effective index to predict the occurrence of DKD. This needs to be verified in furt-her prospective investigations.