Abstract：
OBJECTIVE: Many factors influence male sexual function, including metabolic disorders such as metabolic syndrome (MetS). We aimed to investigate the effects of two metabolic indices, the triglyceride-glucose (TyG) index and the visceral adiposity index (VAI), on male sexual function.
METHODS: A total of 400 men having sexual dysfunction were included. Anthropological data, comorbidities were recorded. Serum total testosterone, prolactin, and estradiol levels were recorded. Sex-specific VAI was calculated using the [(WC/39.68) + (1.88xMI)] × (TG/1.03) × (1.31/HDL) formula and using Ln (fasting triglycerides) × (fasting glucose)/2] formula, TyG index was calculated. Turkish-validated 15-item long-form of the International Index of Erectile Dysfunction (IIEF) questionnaire and male sexual health questionnaire (MSHQ) were used for erectile function and ejaculatory function, respectively. The ROC analysis was used to evaluate the predictive abilities of TyG and VAI cut-off values for ED risk.
RESULTS: A higher TyG index and VAI were associated with an increased risk of ED. The presence of MetS further worsened sexual function, with lower scores in sexual satisfaction, orgasm, desire, and general satisfaction. The TyG index and VAI showed similar predictive abilities for ED. Patients with MetS had worse ejaculation quality compared to those without MetS.
CONCLUSIONS: These findings highlight the potential of the TyG index and VAI as convenient tools for predicting and assessing sexual dysfunction in men, particularly in the context of metabolic disorders. Early detection and intervention for metabolic syndrome and insulin resistance may help to mitigate their negative impact on male sexual function.
METHODS: A total of 400 men having sexual dysfunction were included. Anthropological data, comorbidities were recorded. Serum total testosterone, prolactin, and estradiol levels were recorded. Sex-specific VAI was calculated using the [(WC/39.68) + (1.88xMI)] × (TG/1.03) × (1.31/HDL) formula and using Ln (fasting triglycerides) × (fasting glucose)/2] formula, TyG index was calculated. Turkish-validated 15-item long-form of the International Index of Erectile Dysfunction (IIEF) questionnaire and male sexual health questionnaire (MSHQ) were used for erectile function and ejaculatory function, respectively. The ROC analysis was used to evaluate the predictive abilities of TyG and VAI cut-off values for ED risk.
RESULTS: A higher TyG index and VAI were associated with an increased risk of ED. The presence of MetS further worsened sexual function, with lower scores in sexual satisfaction, orgasm, desire, and general satisfaction. The TyG index and VAI showed similar predictive abilities for ED. Patients with MetS had worse ejaculation quality compared to those without MetS.
CONCLUSIONS: These findings highlight the potential of the TyG index and VAI as convenient tools for predicting and assessing sexual dysfunction in men, particularly in the context of metabolic disorders. Early detection and intervention for metabolic syndrome and insulin resistance may help to mitigate their negative impact on male sexual function.
摘要：
目的：影响男性性功能的因素很多，包括代谢紊乱，如代谢综合征（MetS）。我们的目的是研究两种代谢指标的影响，甘油三酯-葡萄糖(TyG)指数和内脏肥胖指数(VAI)，男性性功能。
方法：共纳入400名患有性功能障碍的男性。人类学数据,记录合并症。血清总睾酮,催乳素,并记录雌二醇水平。使用[(WC/39.68)+(1.88xMI)]×(TG/1.03)×(1.31/HDL)公式和Ln(空腹甘油三酯)×(空腹血糖)/2]公式计算性别特异性VAI，计算TyG指数。使用土耳其语验证的15项长形式的国际勃起功能障碍指数（IIEF）问卷和男性性健康问卷（MSHQ）用于勃起功能和射精功能，分别。ROC分析用于评估TyG和VAI临界值对ED风险的预测能力。
结果：较高的TyG指数和VAI与ED风险增加相关。MetS的存在进一步恶化了性功能，性满意度得分较低，性高潮,欲望,和一般的满意度。TyG指数和VAI对ED的预测能力相似。与没有MetS的患者相比，患有MetS的患者的射精质量较差。
结论：这些发现强调了TyG指数和VAI作为预测和评估男性性功能障碍的便利工具的潜力。特别是在代谢紊乱的背景下。早期发现和干预代谢综合征和胰岛素抵抗可能有助于减轻其对男性性功能的负面影响。
方法：共纳入400名患有性功能障碍的男性。人类学数据,记录合并症。血清总睾酮,催乳素,并记录雌二醇水平。使用[(WC/39.68)+(1.88xMI)]×(TG/1.03)×(1.31/HDL)公式和Ln(空腹甘油三酯)×(空腹血糖)/2]公式计算性别特异性VAI，计算TyG指数。使用土耳其语验证的15项长形式的国际勃起功能障碍指数（IIEF）问卷和男性性健康问卷（MSHQ）用于勃起功能和射精功能，分别。ROC分析用于评估TyG和VAI临界值对ED风险的预测能力。
结果：较高的TyG指数和VAI与ED风险增加相关。MetS的存在进一步恶化了性功能，性满意度得分较低，性高潮,欲望,和一般的满意度。TyG指数和VAI对ED的预测能力相似。与没有MetS的患者相比，患有MetS的患者的射精质量较差。
结论：这些发现强调了TyG指数和VAI作为预测和评估男性性功能障碍的便利工具的潜力。特别是在代谢紊乱的背景下。早期发现和干预代谢综合征和胰岛素抵抗可能有助于减轻其对男性性功能的负面影响。
