在COVID-19大流行期间,具有特定特征的不同SARS-CoV-2变体(VOC)已经出现并在世界范围内传播。同时,临床医师在患者入院时和住院期间常规评估某些血液检查的结果,以评估疾病严重程度和患者总体状况.在本研究中,我们在受Alpha影响的患者中搜索了显著的血细胞计数和生物标志物差异,入场时的Delta和OmicronVOCs。检索了330名患者的年龄数据,性别,VOC,细胞血细胞计数结果(白细胞,Neut%,淋巴%,Ig%,PLT),常见的生物标志物(D-二聚体,尿素,肌酐,SGOT,SGPT,CRP,IL-6,suPAR),ICU入院和死亡。使用方差分析进行统计分析,Kruskal-Wallis测试,双向方差分析,卡方,T检验,适当时使用SPSSv.28和STATA14进行Mann-Whitney检验和逻辑回归.年龄和VOC与住院显著相关,而VOC组之间的WBC存在显著差异,PLT,Neut%,IL-6,肌酐,CRP,D-二聚体和suPAR。我们的分析表明,在当前的大流行中,不仅SARS-CoV-2VOCs,而且用于评估患者入院时状态的实验室参数也会发生变化。
During the COVID-19 pandemic, different SARS-CoV-2 variants of concern (
VOC) with specific characteristics have emerged and spread worldwide. At the same time, clinicians routinely evaluate the results of certain blood tests upon patient admission as well as during hospitalization to assess disease severity and the overall patient status. In the present
study, we searched for significant cell blood count and biomarker differences among patients affected with the Alpha, Delta and Omicron VOCs at admission. Data from 330 patients were retrieved regarding age, gender,
VOC, cell blood count results (WBC, Neut%, Lymph%, Ig%, PLT), common biomarkers (D-dimers, urea, creatinine, SGOT, SGPT, CRP, IL-6, suPAR), ICU admission and death. Statistical analyses were performed using ANOVA, the Kruskal-Wallis test, two-way ANOVA, Chi-square, T-test, the Mann-Whitney test and logistic regression was performed where appropriate using SPSS v.28 and STATA 14. Age and
VOC were significantly associated with hospitalization, whereas significant differences among
VOC groups were found for WBC, PLT, Neut%, IL-6, creatinine, CRP, D-dimers and suPAR. Our analyses showed that throughout the current pandemic, not only the SARS-CoV-2 VOCs but also the laboratory parameters that are used to evaluate the patient\'s status at admission are subject to changes.